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Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications

Standard

Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications. / Smeets, Ralf; Vorwig, Oliver; Wöltje, Michael; Gaudin, Robert; Lübke, Andreas; Beck-Broichsitter, Benedicta; Rheinnecker, Michael; Heiland, Max; Grupp, Katharina; Gröbe, Alexander; Hanken, Henning.

In: OR SURG OR MED OR PA, Vol. 121, No. 5, 05.2016, p. e97-e103.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Smeets, R, Vorwig, O, Wöltje, M, Gaudin, R, Lübke, A, Beck-Broichsitter, B, Rheinnecker, M, Heiland, M, Grupp, K, Gröbe, A & Hanken, H 2016, 'Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications', OR SURG OR MED OR PA, vol. 121, no. 5, pp. e97-e103. https://doi.org/10.1016/j.oooo.2016.01.009

APA

Smeets, R., Vorwig, O., Wöltje, M., Gaudin, R., Lübke, A., Beck-Broichsitter, B., Rheinnecker, M., Heiland, M., Grupp, K., Gröbe, A., & Hanken, H. (2016). Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications. OR SURG OR MED OR PA, 121(5), e97-e103. https://doi.org/10.1016/j.oooo.2016.01.009

Vancouver

Smeets R, Vorwig O, Wöltje M, Gaudin R, Lübke A, Beck-Broichsitter B et al. Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications. OR SURG OR MED OR PA. 2016 May;121(5):e97-e103. https://doi.org/10.1016/j.oooo.2016.01.009

Bibtex

@article{0308dc2bf0ea488c843cfecbc78510e9,
title = "Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications",
abstract = "OBJECTIVE: To evaluate a novel microvascular anastomosis technique using N-fibroin stents.STUDY DESIGN: Cylinder stents of 1 mm diameter and 5 mm length were fabricated using N-fibroin from silkworms. In 22 rats, aortas were dissected, and the stent was inserted into the two ends of the aorta and fixed using methylmethacrylate.RESULTS: Stent anastomosis was successful in 21 (96%) rats. The mean ischemia time was 7.4 minutes, significantly shorter than the 15.9 minutes in the control group with conventional sutures (P < .0001). After 4 months, anastomosis was functionally patent in all cases. However, elastic fibers remained interrupted in all stent anastomosis cases, and marked host rejection was evident at the stent anastomosis sites. Around the stents, thrombi were frequent (52%).CONCLUSIONS: Our study demonstrated the basic feasibility of stent anastomosis using N-fibroin stents and reduced ischemia time. However, thrombus formation, frequent and severe abdominal infections, and heavy host rejection remain critical issues.",
author = "Ralf Smeets and Oliver Vorwig and Michael W{\"o}ltje and Robert Gaudin and Andreas L{\"u}bke and Benedicta Beck-Broichsitter and Michael Rheinnecker and Max Heiland and Katharina Grupp and Alexander Gr{\"o}be and Henning Hanken",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = may,
doi = "10.1016/j.oooo.2016.01.009",
language = "English",
volume = "121",
pages = "e97--e103",
journal = "OR SURG OR MED OR PA",
issn = "2212-4403",
publisher = "Elsevier USA",
number = "5",

}

RIS

TY - JOUR

T1 - Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications

AU - Smeets, Ralf

AU - Vorwig, Oliver

AU - Wöltje, Michael

AU - Gaudin, Robert

AU - Lübke, Andreas

AU - Beck-Broichsitter, Benedicta

AU - Rheinnecker, Michael

AU - Heiland, Max

AU - Grupp, Katharina

AU - Gröbe, Alexander

AU - Hanken, Henning

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/5

Y1 - 2016/5

N2 - OBJECTIVE: To evaluate a novel microvascular anastomosis technique using N-fibroin stents.STUDY DESIGN: Cylinder stents of 1 mm diameter and 5 mm length were fabricated using N-fibroin from silkworms. In 22 rats, aortas were dissected, and the stent was inserted into the two ends of the aorta and fixed using methylmethacrylate.RESULTS: Stent anastomosis was successful in 21 (96%) rats. The mean ischemia time was 7.4 minutes, significantly shorter than the 15.9 minutes in the control group with conventional sutures (P < .0001). After 4 months, anastomosis was functionally patent in all cases. However, elastic fibers remained interrupted in all stent anastomosis cases, and marked host rejection was evident at the stent anastomosis sites. Around the stents, thrombi were frequent (52%).CONCLUSIONS: Our study demonstrated the basic feasibility of stent anastomosis using N-fibroin stents and reduced ischemia time. However, thrombus formation, frequent and severe abdominal infections, and heavy host rejection remain critical issues.

AB - OBJECTIVE: To evaluate a novel microvascular anastomosis technique using N-fibroin stents.STUDY DESIGN: Cylinder stents of 1 mm diameter and 5 mm length were fabricated using N-fibroin from silkworms. In 22 rats, aortas were dissected, and the stent was inserted into the two ends of the aorta and fixed using methylmethacrylate.RESULTS: Stent anastomosis was successful in 21 (96%) rats. The mean ischemia time was 7.4 minutes, significantly shorter than the 15.9 minutes in the control group with conventional sutures (P < .0001). After 4 months, anastomosis was functionally patent in all cases. However, elastic fibers remained interrupted in all stent anastomosis cases, and marked host rejection was evident at the stent anastomosis sites. Around the stents, thrombi were frequent (52%).CONCLUSIONS: Our study demonstrated the basic feasibility of stent anastomosis using N-fibroin stents and reduced ischemia time. However, thrombus formation, frequent and severe abdominal infections, and heavy host rejection remain critical issues.

U2 - 10.1016/j.oooo.2016.01.009

DO - 10.1016/j.oooo.2016.01.009

M3 - SCORING: Journal article

C2 - 27068318

VL - 121

SP - e97-e103

JO - OR SURG OR MED OR PA

JF - OR SURG OR MED OR PA

SN - 2212-4403

IS - 5

ER -