Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications
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Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications. / Smeets, Ralf; Vorwig, Oliver; Wöltje, Michael; Gaudin, Robert; Lübke, Andreas; Beck-Broichsitter, Benedicta; Rheinnecker, Michael; Heiland, Max; Grupp, Katharina; Gröbe, Alexander; Hanken, Henning.
in: OR SURG OR MED OR PA, Jahrgang 121, Nr. 5, 05.2016, S. e97-e103.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Microvascular stent anastomosis using N-fibroin stents: feasibility, ischemia time, and complications
AU - Smeets, Ralf
AU - Vorwig, Oliver
AU - Wöltje, Michael
AU - Gaudin, Robert
AU - Lübke, Andreas
AU - Beck-Broichsitter, Benedicta
AU - Rheinnecker, Michael
AU - Heiland, Max
AU - Grupp, Katharina
AU - Gröbe, Alexander
AU - Hanken, Henning
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016/5
Y1 - 2016/5
N2 - OBJECTIVE: To evaluate a novel microvascular anastomosis technique using N-fibroin stents.STUDY DESIGN: Cylinder stents of 1 mm diameter and 5 mm length were fabricated using N-fibroin from silkworms. In 22 rats, aortas were dissected, and the stent was inserted into the two ends of the aorta and fixed using methylmethacrylate.RESULTS: Stent anastomosis was successful in 21 (96%) rats. The mean ischemia time was 7.4 minutes, significantly shorter than the 15.9 minutes in the control group with conventional sutures (P < .0001). After 4 months, anastomosis was functionally patent in all cases. However, elastic fibers remained interrupted in all stent anastomosis cases, and marked host rejection was evident at the stent anastomosis sites. Around the stents, thrombi were frequent (52%).CONCLUSIONS: Our study demonstrated the basic feasibility of stent anastomosis using N-fibroin stents and reduced ischemia time. However, thrombus formation, frequent and severe abdominal infections, and heavy host rejection remain critical issues.
AB - OBJECTIVE: To evaluate a novel microvascular anastomosis technique using N-fibroin stents.STUDY DESIGN: Cylinder stents of 1 mm diameter and 5 mm length were fabricated using N-fibroin from silkworms. In 22 rats, aortas were dissected, and the stent was inserted into the two ends of the aorta and fixed using methylmethacrylate.RESULTS: Stent anastomosis was successful in 21 (96%) rats. The mean ischemia time was 7.4 minutes, significantly shorter than the 15.9 minutes in the control group with conventional sutures (P < .0001). After 4 months, anastomosis was functionally patent in all cases. However, elastic fibers remained interrupted in all stent anastomosis cases, and marked host rejection was evident at the stent anastomosis sites. Around the stents, thrombi were frequent (52%).CONCLUSIONS: Our study demonstrated the basic feasibility of stent anastomosis using N-fibroin stents and reduced ischemia time. However, thrombus formation, frequent and severe abdominal infections, and heavy host rejection remain critical issues.
U2 - 10.1016/j.oooo.2016.01.009
DO - 10.1016/j.oooo.2016.01.009
M3 - SCORING: Journal article
C2 - 27068318
VL - 121
SP - e97-e103
JO - OR SURG OR MED OR PA
JF - OR SURG OR MED OR PA
SN - 2212-4403
IS - 5
ER -