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Microtubules Modulate F-actin Dynamics during Neuronal Polarization

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Microtubules Modulate F-actin Dynamics during Neuronal Polarization. / Zhao, Bing; Meka, Praveen; Scharrenberg, Robin; König, Theresa; Schwanke, Birgit; Kobler, Oliver; Windhorst, Sabine; Kreutz, Michael R; Mikhaylova, Marina; Calderon de Anda, Froylan.

In: SCI REP-UK, Vol. 7, No. 1, 29.08.2017, p. 9583.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zhao, B, Meka, P, Scharrenberg, R, König, T, Schwanke, B, Kobler, O, Windhorst, S, Kreutz, MR, Mikhaylova, M & Calderon de Anda, F 2017, 'Microtubules Modulate F-actin Dynamics during Neuronal Polarization', SCI REP-UK, vol. 7, no. 1, pp. 9583. https://doi.org/10.1038/s41598-017-09832-8

APA

Zhao, B., Meka, P., Scharrenberg, R., König, T., Schwanke, B., Kobler, O., Windhorst, S., Kreutz, M. R., Mikhaylova, M., & Calderon de Anda, F. (2017). Microtubules Modulate F-actin Dynamics during Neuronal Polarization. SCI REP-UK, 7(1), 9583. https://doi.org/10.1038/s41598-017-09832-8

Vancouver

Zhao B, Meka P, Scharrenberg R, König T, Schwanke B, Kobler O et al. Microtubules Modulate F-actin Dynamics during Neuronal Polarization. SCI REP-UK. 2017 Aug 29;7(1):9583. https://doi.org/10.1038/s41598-017-09832-8

Bibtex

@article{db561ac55ab04ad3afa3a132851a4d16,
title = "Microtubules Modulate F-actin Dynamics during Neuronal Polarization",
abstract = "Neuronal polarization is reflected by different dynamics of microtubule and filamentous actin (F-actin). Axonal microtubules are more stable than those in the remaining neurites, while dynamics of F-actin in axonal growth cones clearly exceed those in their dendritic counterparts. However, whether a functional interplay exists between the microtubule network and F-actin dynamics in growing axons and whether this interplay is instrumental for breaking cellular symmetry is currently unknown. Here, we show that an increment on microtubule stability or number of microtubules is associated with increased F-actin dynamics. Moreover, we show that Drebrin E, an F-actin and microtubule plus-end binding protein, mediates this cross talk. Drebrin E segregates preferentially to growth cones with a higher F-actin treadmilling rate, where more microtubule plus-ends are found. Interruption of the interaction of Drebrin E with microtubules decreases F-actin dynamics and arrests neuronal polarization. Collectively the data show that microtubules modulate F-actin dynamics for initial axon extension during neuronal development.",
keywords = "Journal Article",
author = "Bing Zhao and Praveen Meka and Robin Scharrenberg and Theresa K{\"o}nig and Birgit Schwanke and Oliver Kobler and Sabine Windhorst and Kreutz, {Michael R} and Marina Mikhaylova and {Calderon de Anda}, Froylan",
year = "2017",
month = aug,
day = "29",
doi = "10.1038/s41598-017-09832-8",
language = "English",
volume = "7",
pages = "9583",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Microtubules Modulate F-actin Dynamics during Neuronal Polarization

AU - Zhao, Bing

AU - Meka, Praveen

AU - Scharrenberg, Robin

AU - König, Theresa

AU - Schwanke, Birgit

AU - Kobler, Oliver

AU - Windhorst, Sabine

AU - Kreutz, Michael R

AU - Mikhaylova, Marina

AU - Calderon de Anda, Froylan

PY - 2017/8/29

Y1 - 2017/8/29

N2 - Neuronal polarization is reflected by different dynamics of microtubule and filamentous actin (F-actin). Axonal microtubules are more stable than those in the remaining neurites, while dynamics of F-actin in axonal growth cones clearly exceed those in their dendritic counterparts. However, whether a functional interplay exists between the microtubule network and F-actin dynamics in growing axons and whether this interplay is instrumental for breaking cellular symmetry is currently unknown. Here, we show that an increment on microtubule stability or number of microtubules is associated with increased F-actin dynamics. Moreover, we show that Drebrin E, an F-actin and microtubule plus-end binding protein, mediates this cross talk. Drebrin E segregates preferentially to growth cones with a higher F-actin treadmilling rate, where more microtubule plus-ends are found. Interruption of the interaction of Drebrin E with microtubules decreases F-actin dynamics and arrests neuronal polarization. Collectively the data show that microtubules modulate F-actin dynamics for initial axon extension during neuronal development.

AB - Neuronal polarization is reflected by different dynamics of microtubule and filamentous actin (F-actin). Axonal microtubules are more stable than those in the remaining neurites, while dynamics of F-actin in axonal growth cones clearly exceed those in their dendritic counterparts. However, whether a functional interplay exists between the microtubule network and F-actin dynamics in growing axons and whether this interplay is instrumental for breaking cellular symmetry is currently unknown. Here, we show that an increment on microtubule stability or number of microtubules is associated with increased F-actin dynamics. Moreover, we show that Drebrin E, an F-actin and microtubule plus-end binding protein, mediates this cross talk. Drebrin E segregates preferentially to growth cones with a higher F-actin treadmilling rate, where more microtubule plus-ends are found. Interruption of the interaction of Drebrin E with microtubules decreases F-actin dynamics and arrests neuronal polarization. Collectively the data show that microtubules modulate F-actin dynamics for initial axon extension during neuronal development.

KW - Journal Article

U2 - 10.1038/s41598-017-09832-8

DO - 10.1038/s41598-017-09832-8

M3 - SCORING: Journal article

C2 - 28851982

VL - 7

SP - 9583

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -