Microbial interactions in Staphylococcus epidermidis biofilms
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Microbial interactions in Staphylococcus epidermidis biofilms. / Mack, Dietrich; Davies, Angharad P; Harris, Llinos G; Rohde, Holger; Horstkotte, Matthias A; Knobloch, Johannes K-M.
In: ANAL BIOANAL CHEM, Vol. 387, No. 2, 2, 2007, p. 399-408.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Microbial interactions in Staphylococcus epidermidis biofilms
AU - Mack, Dietrich
AU - Davies, Angharad P
AU - Harris, Llinos G
AU - Rohde, Holger
AU - Horstkotte, Matthias A
AU - Knobloch, Johannes K-M
PY - 2007
Y1 - 2007
N2 - Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. The formation of adherent, multilayered bacterial biofilms is the most important factor in the pathogenesis of these infections, which regularly fail to respond to appropriate antimicrobial therapy. Progress in elucidating the factors functional in elaboration of S. epidermidis biofilms and the regulation of their expression with a special emphasis on the role of quorum sensing are reviewed. Significant progress has been made in recent years, which provides the rationale for developing better preventive, therapeutic and diagnostic measures.
AB - Medical device-associated infections, most frequently caused by coagulase-negative staphylococci, especially Staphylococcus epidermidis, are of increasing importance in modern medicine. The formation of adherent, multilayered bacterial biofilms is the most important factor in the pathogenesis of these infections, which regularly fail to respond to appropriate antimicrobial therapy. Progress in elucidating the factors functional in elaboration of S. epidermidis biofilms and the regulation of their expression with a special emphasis on the role of quorum sensing are reviewed. Significant progress has been made in recent years, which provides the rationale for developing better preventive, therapeutic and diagnostic measures.
U2 - 10.1007/s00216-006-0745-2
DO - 10.1007/s00216-006-0745-2
M3 - SCORING: Journal article
VL - 387
SP - 399
EP - 408
JO - ANAL BIOANAL CHEM
JF - ANAL BIOANAL CHEM
SN - 1618-2642
IS - 2
M1 - 2
ER -