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Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory

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Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. / Senn, Claudia; Kutsche, Michael; Saghatelyan, Armen; Bösl, Michael R; Löhler, Jürgen; Bartsch, Udo; Morellini, Fabio; Schachner, Melitta.

In: MOL CELL NEUROSCI, Vol. 20, No. 4, 08.2002, p. 712-29.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Senn, C, Kutsche, M, Saghatelyan, A, Bösl, MR, Löhler, J, Bartsch, U, Morellini, F & Schachner, M 2002, 'Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory', MOL CELL NEUROSCI, vol. 20, no. 4, pp. 712-29.

APA

Senn, C., Kutsche, M., Saghatelyan, A., Bösl, M. R., Löhler, J., Bartsch, U., Morellini, F., & Schachner, M. (2002). Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. MOL CELL NEUROSCI, 20(4), 712-29.

Vancouver

Senn C, Kutsche M, Saghatelyan A, Bösl MR, Löhler J, Bartsch U et al. Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. MOL CELL NEUROSCI. 2002 Aug;20(4):712-29.

Bibtex

@article{65f8ab41e5ae49b39c9d3af4927f1ca7,
title = "Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory",
abstract = "The HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. To characterize the functional role of the HNK-1 carbohydrate in vivo, we have generated mice deficient for the HNK-1 sulfotransferase (ST). The ST-/- allele is inherited with Mendelian frequencies, and the ST-/- mice are viable and fertile. The anatomy of all major brain areas appeared histologically normal. However, basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus was increased and long-term potentiation evoked by theta-burst stimulation was reduced in ST mutants. In the water maze, ST-/- mice showed an impaired long-term memory and a poorer spatial learning when a short inter-trial interval was used. These observations indicate an essential role for the sulfate group of the HNK-1 carbohydrate in synaptic plasticity of the hippocampus.",
keywords = "Animals, In Vitro Techniques, Long-Term Potentiation, Male, Maze Learning, Memory, Mice, Mice, Knockout, Rats, Sulfotransferases, Swimming, Synapses, Synaptic Transmission, Time Factors",
author = "Claudia Senn and Michael Kutsche and Armen Saghatelyan and B{\"o}sl, {Michael R} and J{\"u}rgen L{\"o}hler and Udo Bartsch and Fabio Morellini and Melitta Schachner",
year = "2002",
month = aug,
language = "English",
volume = "20",
pages = "712--29",
journal = "MOL CELL NEUROSCI",
issn = "1044-7431",
publisher = "Academic Press Inc.",
number = "4",

}

RIS

TY - JOUR

T1 - Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory

AU - Senn, Claudia

AU - Kutsche, Michael

AU - Saghatelyan, Armen

AU - Bösl, Michael R

AU - Löhler, Jürgen

AU - Bartsch, Udo

AU - Morellini, Fabio

AU - Schachner, Melitta

PY - 2002/8

Y1 - 2002/8

N2 - The HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. To characterize the functional role of the HNK-1 carbohydrate in vivo, we have generated mice deficient for the HNK-1 sulfotransferase (ST). The ST-/- allele is inherited with Mendelian frequencies, and the ST-/- mice are viable and fertile. The anatomy of all major brain areas appeared histologically normal. However, basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus was increased and long-term potentiation evoked by theta-burst stimulation was reduced in ST mutants. In the water maze, ST-/- mice showed an impaired long-term memory and a poorer spatial learning when a short inter-trial interval was used. These observations indicate an essential role for the sulfate group of the HNK-1 carbohydrate in synaptic plasticity of the hippocampus.

AB - The HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. To characterize the functional role of the HNK-1 carbohydrate in vivo, we have generated mice deficient for the HNK-1 sulfotransferase (ST). The ST-/- allele is inherited with Mendelian frequencies, and the ST-/- mice are viable and fertile. The anatomy of all major brain areas appeared histologically normal. However, basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus was increased and long-term potentiation evoked by theta-burst stimulation was reduced in ST mutants. In the water maze, ST-/- mice showed an impaired long-term memory and a poorer spatial learning when a short inter-trial interval was used. These observations indicate an essential role for the sulfate group of the HNK-1 carbohydrate in synaptic plasticity of the hippocampus.

KW - Animals

KW - In Vitro Techniques

KW - Long-Term Potentiation

KW - Male

KW - Maze Learning

KW - Memory

KW - Mice

KW - Mice, Knockout

KW - Rats

KW - Sulfotransferases

KW - Swimming

KW - Synapses

KW - Synaptic Transmission

KW - Time Factors

M3 - SCORING: Journal article

C2 - 12213450

VL - 20

SP - 712

EP - 729

JO - MOL CELL NEUROSCI

JF - MOL CELL NEUROSCI

SN - 1044-7431

IS - 4

ER -