Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory
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Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory. / Senn, Claudia; Kutsche, Michael; Saghatelyan, Armen; Bösl, Michael R; Löhler, Jürgen; Bartsch, Udo; Morellini, Fabio; Schachner, Melitta.
in: MOL CELL NEUROSCI, Jahrgang 20, Nr. 4, 08.2002, S. 712-29.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Mice deficient for the HNK-1 sulfotransferase show alterations in synaptic efficacy and spatial learning and memory
AU - Senn, Claudia
AU - Kutsche, Michael
AU - Saghatelyan, Armen
AU - Bösl, Michael R
AU - Löhler, Jürgen
AU - Bartsch, Udo
AU - Morellini, Fabio
AU - Schachner, Melitta
PY - 2002/8
Y1 - 2002/8
N2 - The HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. To characterize the functional role of the HNK-1 carbohydrate in vivo, we have generated mice deficient for the HNK-1 sulfotransferase (ST). The ST-/- allele is inherited with Mendelian frequencies, and the ST-/- mice are viable and fertile. The anatomy of all major brain areas appeared histologically normal. However, basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus was increased and long-term potentiation evoked by theta-burst stimulation was reduced in ST mutants. In the water maze, ST-/- mice showed an impaired long-term memory and a poorer spatial learning when a short inter-trial interval was used. These observations indicate an essential role for the sulfate group of the HNK-1 carbohydrate in synaptic plasticity of the hippocampus.
AB - The HNK-1 carbohydrate structure, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. To characterize the functional role of the HNK-1 carbohydrate in vivo, we have generated mice deficient for the HNK-1 sulfotransferase (ST). The ST-/- allele is inherited with Mendelian frequencies, and the ST-/- mice are viable and fertile. The anatomy of all major brain areas appeared histologically normal. However, basal synaptic transmission in pyramidal cells in the CA1 region of the hippocampus was increased and long-term potentiation evoked by theta-burst stimulation was reduced in ST mutants. In the water maze, ST-/- mice showed an impaired long-term memory and a poorer spatial learning when a short inter-trial interval was used. These observations indicate an essential role for the sulfate group of the HNK-1 carbohydrate in synaptic plasticity of the hippocampus.
KW - Animals
KW - In Vitro Techniques
KW - Long-Term Potentiation
KW - Male
KW - Maze Learning
KW - Memory
KW - Mice
KW - Mice, Knockout
KW - Rats
KW - Sulfotransferases
KW - Swimming
KW - Synapses
KW - Synaptic Transmission
KW - Time Factors
M3 - SCORING: Journal article
C2 - 12213450
VL - 20
SP - 712
EP - 729
JO - MOL CELL NEUROSCI
JF - MOL CELL NEUROSCI
SN - 1044-7431
IS - 4
ER -