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Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

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Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. / Ruggeri, Barbara; Macare, Christine; Stopponi, Serena; Jia, Tianye; Carvalho, Fabiana M; Robert, Gabriel; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Vetter, Nora C; Walter, Henrik; Whelan, Robert; Sommer, Wolfgang H; Bakalkin, Georgy; Ciccocioppo, Roberto; Schumann, Gunter; IMAGEN Consortium.

In: J CHILD PSYCHOL PSYC, Vol. 59, No. 6, 06.2018, p. 650-658.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ruggeri, B, Macare, C, Stopponi, S, Jia, T, Carvalho, FM, Robert, G, Banaschewski, T, Bokde, ALW, Bromberg, U, Büchel, C, Cattrell, A, Conrod, PJ, Desrivières, S, Flor, H, Frouin, V, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Martinot, JL, Martinot, M-LP, Nees, F, Papadopoulos-Orfanos, D, Paus, T, Poustka, L, Smolka, MN, Vetter, NC, Walter, H, Whelan, R, Sommer, WH, Bakalkin, G, Ciccocioppo, R, Schumann, G & IMAGEN Consortium 2018, 'Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents', J CHILD PSYCHOL PSYC, vol. 59, no. 6, pp. 650-658. https://doi.org/10.1111/jcpp.12843

APA

Ruggeri, B., Macare, C., Stopponi, S., Jia, T., Carvalho, F. M., Robert, G., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Cattrell, A., Conrod, P. J., Desrivières, S., Flor, H., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., ... IMAGEN Consortium (2018). Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. J CHILD PSYCHOL PSYC, 59(6), 650-658. https://doi.org/10.1111/jcpp.12843

Vancouver

Ruggeri B, Macare C, Stopponi S, Jia T, Carvalho FM, Robert G et al. Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. J CHILD PSYCHOL PSYC. 2018 Jun;59(6):650-658. https://doi.org/10.1111/jcpp.12843

Bibtex

@article{c102c0cce027488d94631ff64e10229a,
title = "Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents",
abstract = "BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.",
keywords = "Journal Article",
author = "Barbara Ruggeri and Christine Macare and Serena Stopponi and Tianye Jia and Carvalho, {Fabiana M} and Gabriel Robert and Tobias Banaschewski and Bokde, {Arun L W} and Uli Bromberg and Christian B{\"u}chel and Anna Cattrell and Conrod, {Patricia J} and Sylvane Desrivi{\`e}res and Herta Flor and Vincent Frouin and J{\"u}rgen Gallinat and Hugh Garavan and Penny Gowland and Andreas Heinz and Bernd Ittermann and Martinot, {Jean Luc} and Martinot, {Marie-Laure Paill{\`e}re} and Frauke Nees and Dimitri Papadopoulos-Orfanos and Tom{\'a}{\v s} Paus and Luise Poustka and Smolka, {Michael N} and Vetter, {Nora C} and Henrik Walter and Robert Whelan and Sommer, {Wolfgang H} and Georgy Bakalkin and Roberto Ciccocioppo and Gunter Schumann and {IMAGEN Consortium}",
note = "{\textcopyright} 2017 Association for Child and Adolescent Mental Health.",
year = "2018",
month = jun,
doi = "10.1111/jcpp.12843",
language = "English",
volume = "59",
pages = "650--658",
journal = "J CHILD PSYCHOL PSYC",
issn = "0021-9630",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents

AU - Ruggeri, Barbara

AU - Macare, Christine

AU - Stopponi, Serena

AU - Jia, Tianye

AU - Carvalho, Fabiana M

AU - Robert, Gabriel

AU - Banaschewski, Tobias

AU - Bokde, Arun L W

AU - Bromberg, Uli

AU - Büchel, Christian

AU - Cattrell, Anna

AU - Conrod, Patricia J

AU - Desrivières, Sylvane

AU - Flor, Herta

AU - Frouin, Vincent

AU - Gallinat, Jürgen

AU - Garavan, Hugh

AU - Gowland, Penny

AU - Heinz, Andreas

AU - Ittermann, Bernd

AU - Martinot, Jean Luc

AU - Martinot, Marie-Laure Paillère

AU - Nees, Frauke

AU - Papadopoulos-Orfanos, Dimitri

AU - Paus, Tomáš

AU - Poustka, Luise

AU - Smolka, Michael N

AU - Vetter, Nora C

AU - Walter, Henrik

AU - Whelan, Robert

AU - Sommer, Wolfgang H

AU - Bakalkin, Georgy

AU - Ciccocioppo, Roberto

AU - Schumann, Gunter

AU - IMAGEN Consortium

N1 - © 2017 Association for Child and Adolescent Mental Health.

PY - 2018/6

Y1 - 2018/6

N2 - BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.

AB - BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.

KW - Journal Article

U2 - 10.1111/jcpp.12843

DO - 10.1111/jcpp.12843

M3 - SCORING: Journal article

C2 - 29197086

VL - 59

SP - 650

EP - 658

JO - J CHILD PSYCHOL PSYC

JF - J CHILD PSYCHOL PSYC

SN - 0021-9630

IS - 6

ER -