Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents
Standard
Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents. / Ruggeri, Barbara; Macare, Christine; Stopponi, Serena; Jia, Tianye; Carvalho, Fabiana M; Robert, Gabriel; Banaschewski, Tobias; Bokde, Arun L W; Bromberg, Uli; Büchel, Christian; Cattrell, Anna; Conrod, Patricia J; Desrivières, Sylvane; Flor, Herta; Frouin, Vincent; Gallinat, Jürgen; Garavan, Hugh; Gowland, Penny; Heinz, Andreas; Ittermann, Bernd; Martinot, Jean Luc; Martinot, Marie-Laure Paillère; Nees, Frauke; Papadopoulos-Orfanos, Dimitri; Paus, Tomáš; Poustka, Luise; Smolka, Michael N; Vetter, Nora C; Walter, Henrik; Whelan, Robert; Sommer, Wolfgang H; Bakalkin, Georgy; Ciccocioppo, Roberto; Schumann, Gunter; IMAGEN Consortium.
in: J CHILD PSYCHOL PSYC, Jahrgang 59, Nr. 6, 06.2018, S. 650-658.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents
AU - Ruggeri, Barbara
AU - Macare, Christine
AU - Stopponi, Serena
AU - Jia, Tianye
AU - Carvalho, Fabiana M
AU - Robert, Gabriel
AU - Banaschewski, Tobias
AU - Bokde, Arun L W
AU - Bromberg, Uli
AU - Büchel, Christian
AU - Cattrell, Anna
AU - Conrod, Patricia J
AU - Desrivières, Sylvane
AU - Flor, Herta
AU - Frouin, Vincent
AU - Gallinat, Jürgen
AU - Garavan, Hugh
AU - Gowland, Penny
AU - Heinz, Andreas
AU - Ittermann, Bernd
AU - Martinot, Jean Luc
AU - Martinot, Marie-Laure Paillère
AU - Nees, Frauke
AU - Papadopoulos-Orfanos, Dimitri
AU - Paus, Tomáš
AU - Poustka, Luise
AU - Smolka, Michael N
AU - Vetter, Nora C
AU - Walter, Henrik
AU - Whelan, Robert
AU - Sommer, Wolfgang H
AU - Bakalkin, Georgy
AU - Ciccocioppo, Roberto
AU - Schumann, Gunter
AU - IMAGEN Consortium
N1 - © 2017 Association for Child and Adolescent Mental Health.
PY - 2018/6
Y1 - 2018/6
N2 - BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.
AB - BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders.METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity.RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens.CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse.
KW - Journal Article
U2 - 10.1111/jcpp.12843
DO - 10.1111/jcpp.12843
M3 - SCORING: Journal article
C2 - 29197086
VL - 59
SP - 650
EP - 658
JO - J CHILD PSYCHOL PSYC
JF - J CHILD PSYCHOL PSYC
SN - 0021-9630
IS - 6
ER -