Methotrexate plus leflunomide for the treatment of relapsingWegener's granulomatosis. A retrospective uncontrolled study.
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Methotrexate plus leflunomide for the treatment of relapsingWegener's granulomatosis. A retrospective uncontrolled study. / Bremer, Jan P; Ullrich, Sebastian; Laudien, Martin; Gross, Wolfgang L; Lamprecht, Peter.
In: CLIN EXP RHEUMATOL, Vol. 28(1 Suppl 57), 2010, p. 67-71.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Methotrexate plus leflunomide for the treatment of relapsingWegener's granulomatosis. A retrospective uncontrolled study.
AU - Bremer, Jan P
AU - Ullrich, Sebastian
AU - Laudien, Martin
AU - Gross, Wolfgang L
AU - Lamprecht, Peter
PY - 2010
Y1 - 2010
N2 - While remission is achieved in the majority of Wegener's granulomatosis (WG)-patients with cyclophosphamide, maintenance of remission remains a challenge due to the high rate of relapses. The purpose of this study was to evaluate the safety and efficacy of the combination of methotrexate (MTX) plus leflunomide (LEF) for the treatment of minor relapsing WG not warranting cyclophosphamide.
AB - While remission is achieved in the majority of Wegener's granulomatosis (WG)-patients with cyclophosphamide, maintenance of remission remains a challenge due to the high rate of relapses. The purpose of this study was to evaluate the safety and efficacy of the combination of methotrexate (MTX) plus leflunomide (LEF) for the treatment of minor relapsing WG not warranting cyclophosphamide.
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - dosage
KW - control
KW - Retrospective Studies
KW - Remission Induction
KW - Drug Therapy, Combination
KW - Recurrence prevention
KW - Immunosuppressive Agents administration
KW - Anti-Inflammatory Agents, Non-Steroidal administration
KW - Isoxazoles administration
KW - Methotrexate administration
KW - Wegener Granulomatosis drug therapy
KW - Adult
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Middle Aged
KW - Adolescent
KW - Young Adult
KW - dosage
KW - control
KW - Retrospective Studies
KW - Remission Induction
KW - Drug Therapy, Combination
KW - Recurrence prevention
KW - Immunosuppressive Agents administration
KW - Anti-Inflammatory Agents, Non-Steroidal administration
KW - Isoxazoles administration
KW - Methotrexate administration
KW - Wegener Granulomatosis drug therapy
M3 - SCORING: Zeitschriftenaufsatz
VL - 28(1 Suppl 57)
SP - 67
EP - 71
JO - CLIN EXP RHEUMATOL
JF - CLIN EXP RHEUMATOL
SN - 0392-856X
ER -