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Metabotropic glutamate receptors

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Metabotropic glutamate receptors : intracellular signaling pathways. / Gerber, Urs; Gee, Christine E; Benquet, Pascal.

In: CURR OPIN PHARMACOL, Vol. 7, No. 1, 01.02.2007, p. 56-61.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gerber, U, Gee, CE & Benquet, P 2007, 'Metabotropic glutamate receptors: intracellular signaling pathways', CURR OPIN PHARMACOL, vol. 7, no. 1, pp. 56-61. https://doi.org/10.1016/j.coph.2006.08.008

APA

Gerber, U., Gee, C. E., & Benquet, P. (2007). Metabotropic glutamate receptors: intracellular signaling pathways. CURR OPIN PHARMACOL, 7(1), 56-61. https://doi.org/10.1016/j.coph.2006.08.008

Vancouver

Gerber U, Gee CE, Benquet P. Metabotropic glutamate receptors: intracellular signaling pathways. CURR OPIN PHARMACOL. 2007 Feb 1;7(1):56-61. https://doi.org/10.1016/j.coph.2006.08.008

Bibtex

@article{cd6da1ee8529470ca80ba5867dae3140,
title = "Metabotropic glutamate receptors: intracellular signaling pathways",
abstract = "Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.",
keywords = "Animals, Arrestins, Calcium, GTP-Binding Proteins, Neurons, Protein Biosynthesis, Receptors, Metabotropic Glutamate, Signal Transduction, Transcription, Genetic",
author = "Urs Gerber and Gee, {Christine E} and Pascal Benquet",
year = "2007",
month = feb,
day = "1",
doi = "10.1016/j.coph.2006.08.008",
language = "English",
volume = "7",
pages = "56--61",
number = "1",

}

RIS

TY - JOUR

T1 - Metabotropic glutamate receptors

T2 - intracellular signaling pathways

AU - Gerber, Urs

AU - Gee, Christine E

AU - Benquet, Pascal

PY - 2007/2/1

Y1 - 2007/2/1

N2 - Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.

AB - Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.

KW - Animals

KW - Arrestins

KW - Calcium

KW - GTP-Binding Proteins

KW - Neurons

KW - Protein Biosynthesis

KW - Receptors, Metabotropic Glutamate

KW - Signal Transduction

KW - Transcription, Genetic

U2 - 10.1016/j.coph.2006.08.008

DO - 10.1016/j.coph.2006.08.008

M3 - SCORING: Journal article

C2 - 17055336

VL - 7

SP - 56

EP - 61

IS - 1

ER -