Metabotropic glutamate receptors
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Metabotropic glutamate receptors : intracellular signaling pathways. / Gerber, Urs; Gee, Christine E; Benquet, Pascal.
in: CURR OPIN PHARMACOL, Jahrgang 7, Nr. 1, 01.02.2007, S. 56-61.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Metabotropic glutamate receptors
T2 - intracellular signaling pathways
AU - Gerber, Urs
AU - Gee, Christine E
AU - Benquet, Pascal
PY - 2007/2/1
Y1 - 2007/2/1
N2 - Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.
AB - Metabotropic glutamate receptors are classified into three groups, primarily on the basis of sequence similarity and whether they positively couple to the phospholipase C cascade or negatively couple to adenylyl cyclases. The past decade of research, drawing on sophisticated molecular approaches, has revealed a multitude of additional intracellular components that assemble as protein scaffolds around neuronal metabotropic glutamate receptors, establishing functional links to postsynaptic density structures, to membrane-bound enzymes and ion channels, and to the nucleus. Characterization of these novel transduction mechanisms is providing new insights into the roles of metabotropic glutamate receptors in the regulation and modulation of diverse functions in the nervous system.
KW - Animals
KW - Arrestins
KW - Calcium
KW - GTP-Binding Proteins
KW - Neurons
KW - Protein Biosynthesis
KW - Receptors, Metabotropic Glutamate
KW - Signal Transduction
KW - Transcription, Genetic
U2 - 10.1016/j.coph.2006.08.008
DO - 10.1016/j.coph.2006.08.008
M3 - SCORING: Journal article
C2 - 17055336
VL - 7
SP - 56
EP - 61
IS - 1
ER -