Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. / Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert; Barathi, Veluchamy A; Hysi, Pirro G; Guggenheim, Jeremy A; Höhn, René; Vitart, Veronique; Khawaja, Anthony P; Yamashiro, Kenji; Hosseini, S Mohsen; Lehtimäki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cécile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E; Williams, Katie M; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F; Joshi, Peter K; McMahon, George; St Pourcain, Beate; Evans, David M; Simpson, Claire L; Schwantes-An, Tae-Hwi; Igo, Robert P; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Céline; Blettner, Maria; Raitakari, Olli; Kähönen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S; Gieger, Christian; Portas, Laura; van Leeuwen, Elisabeth M; Amin, Najaf; Uitterlinden, André G; Rivadeneira, Fernando; Hofman, Albert; Vingerling, Johannes R; Wang, Ya Xing; Wang, Xu; Tai-Hui Boh, Eileen; Ikram, M Kamran; Sabanayagam, Charumathi; Gupta, Preeti; Tan, Vincent; Zhou, Lei; Ho, Candice E H; Lim, Wan'e; Beuerman, Roger W; Siantar, Rosalynn; Tai, E-Shyong; Vithana, Eranga; Mihailov, Evelin; Khor, Chiea-Chuen; Hayward, Caroline; Luben, Robert N; Foster, Paul J; Klein, Barbara E K; Klein, Ronald; Wong, Hoi-Suen; Mitchell, Paul; Metspalu, Andres; Aung, Tin; Young, Terri L; He, Mingguang; Pärssinen, Olavi; van Duijn, Cornelia M; Jin Wang, Jie; Williams, Cathy; Jonas, Jost B; Teo, Yik-Ying; Mackey, David A; Oexle, Konrad; Yoshimura, Nagahisa; Paterson, Andrew D; Pfeiffer, Norbert; Wong, Tien-Yin; Baird, Paul N; Stambolian, Dwight; Wilson, Joan E Bailey; Cheng, Ching-Yu; Hammond, Christopher J; Klaver, Caroline C W; Saw, Seang-Mei; Rahi, Jugnoo S; Korobelnik, Jean-François; Kemp, John P; Timpson, Nicholas J; Smith, George Davey; Craig, Jamie E; Burdon, Kathryn P; Fogarty, Rhys D; Iyengar, Sudha K; Chew, Emily; Janmahasatian, Sarayut; Martin, Nicholas G; MacGregor, Stuart; Xu, Liang; Schache, Maria; Nangia, Vinay; Panda-Jonas, Songhomitra; Wright, Alan F; Fondran, Jeremy R; Lass, Jonathan H; Feng, Sheng; Zhao, Jing Hua; Khaw, Kay-Tee; Wareham, Nick J; Rantanen, Taina; Kaprio, Jaakko; Pang, Chi Pui; Chen, Li Jia; Tam, Pancy O; Jhanji, Vishal; Young, Alvin L; Döring, Angela; Raffel, Leslie J; Cotch, Mary-Frances; Li, Xiaohui; Yip, Shea Ping; Yap, Maurice K H; Biino, Ginevra; Vaccargiu, Simona; Fossarello, Maurizio; Fleck, Brian; Yazar, Seyhan; Tideman, Jan Willem L; Tedja, Milly; Deangelis, Margaret M; Morrison, Margaux; Farrer, Lindsay; Zhou, Xiangtian; Chen, Wei; Mizuki, Nobuhisa; Meguro, Akira; Mäkelä, Kari Matti; Consortium for Refractive Error and Myopia (CREAM).
In: NAT COMMUN, Vol. 7, 29.03.2016, p. 11008.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error
AU - Fan, Qiao
AU - Verhoeven, Virginie J M
AU - Wojciechowski, Robert
AU - Barathi, Veluchamy A
AU - Hysi, Pirro G
AU - Guggenheim, Jeremy A
AU - Höhn, René
AU - Vitart, Veronique
AU - Khawaja, Anthony P
AU - Yamashiro, Kenji
AU - Hosseini, S Mohsen
AU - Lehtimäki, Terho
AU - Lu, Yi
AU - Haller, Toomas
AU - Xie, Jing
AU - Delcourt, Cécile
AU - Pirastu, Mario
AU - Wedenoja, Juho
AU - Gharahkhani, Puya
AU - Venturini, Cristina
AU - Miyake, Masahiro
AU - Hewitt, Alex W
AU - Guo, Xiaobo
AU - Mazur, Johanna
AU - Huffman, Jenifer E
AU - Williams, Katie M
AU - Polasek, Ozren
AU - Campbell, Harry
AU - Rudan, Igor
AU - Vatavuk, Zoran
AU - Wilson, James F
AU - Joshi, Peter K
AU - McMahon, George
AU - St Pourcain, Beate
AU - Evans, David M
AU - Simpson, Claire L
AU - Schwantes-An, Tae-Hwi
AU - Igo, Robert P
AU - Mirshahi, Alireza
AU - Cougnard-Gregoire, Audrey
AU - Bellenguez, Céline
AU - Blettner, Maria
AU - Raitakari, Olli
AU - Kähönen, Mika
AU - Seppala, Ilkka
AU - Zeller, Tanja
AU - Meitinger, Thomas
AU - Ried, Janina S
AU - Gieger, Christian
AU - Portas, Laura
AU - van Leeuwen, Elisabeth M
AU - Amin, Najaf
AU - Uitterlinden, André G
AU - Rivadeneira, Fernando
AU - Hofman, Albert
AU - Vingerling, Johannes R
AU - Wang, Ya Xing
AU - Wang, Xu
AU - Tai-Hui Boh, Eileen
AU - Ikram, M Kamran
AU - Sabanayagam, Charumathi
AU - Gupta, Preeti
AU - Tan, Vincent
AU - Zhou, Lei
AU - Ho, Candice E H
AU - Lim, Wan'e
AU - Beuerman, Roger W
AU - Siantar, Rosalynn
AU - Tai, E-Shyong
AU - Vithana, Eranga
AU - Mihailov, Evelin
AU - Khor, Chiea-Chuen
AU - Hayward, Caroline
AU - Luben, Robert N
AU - Foster, Paul J
AU - Klein, Barbara E K
AU - Klein, Ronald
AU - Wong, Hoi-Suen
AU - Mitchell, Paul
AU - Metspalu, Andres
AU - Aung, Tin
AU - Young, Terri L
AU - He, Mingguang
AU - Pärssinen, Olavi
AU - van Duijn, Cornelia M
AU - Jin Wang, Jie
AU - Williams, Cathy
AU - Jonas, Jost B
AU - Teo, Yik-Ying
AU - Mackey, David A
AU - Oexle, Konrad
AU - Yoshimura, Nagahisa
AU - Paterson, Andrew D
AU - Pfeiffer, Norbert
AU - Wong, Tien-Yin
AU - Baird, Paul N
AU - Stambolian, Dwight
AU - Wilson, Joan E Bailey
AU - Cheng, Ching-Yu
AU - Hammond, Christopher J
AU - Klaver, Caroline C W
AU - Saw, Seang-Mei
AU - Rahi, Jugnoo S
AU - Korobelnik, Jean-François
AU - Kemp, John P
AU - Timpson, Nicholas J
AU - Smith, George Davey
AU - Craig, Jamie E
AU - Burdon, Kathryn P
AU - Fogarty, Rhys D
AU - Iyengar, Sudha K
AU - Chew, Emily
AU - Janmahasatian, Sarayut
AU - Martin, Nicholas G
AU - MacGregor, Stuart
AU - Xu, Liang
AU - Schache, Maria
AU - Nangia, Vinay
AU - Panda-Jonas, Songhomitra
AU - Wright, Alan F
AU - Fondran, Jeremy R
AU - Lass, Jonathan H
AU - Feng, Sheng
AU - Zhao, Jing Hua
AU - Khaw, Kay-Tee
AU - Wareham, Nick J
AU - Rantanen, Taina
AU - Kaprio, Jaakko
AU - Pang, Chi Pui
AU - Chen, Li Jia
AU - Tam, Pancy O
AU - Jhanji, Vishal
AU - Young, Alvin L
AU - Döring, Angela
AU - Raffel, Leslie J
AU - Cotch, Mary-Frances
AU - Li, Xiaohui
AU - Yip, Shea Ping
AU - Yap, Maurice K H
AU - Biino, Ginevra
AU - Vaccargiu, Simona
AU - Fossarello, Maurizio
AU - Fleck, Brian
AU - Yazar, Seyhan
AU - Tideman, Jan Willem L
AU - Tedja, Milly
AU - Deangelis, Margaret M
AU - Morrison, Margaux
AU - Farrer, Lindsay
AU - Zhou, Xiangtian
AU - Chen, Wei
AU - Mizuki, Nobuhisa
AU - Meguro, Akira
AU - Mäkelä, Kari Matti
AU - Consortium for Refractive Error and Myopia (CREAM)
PY - 2016/3/29
Y1 - 2016/3/29
N2 - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
AB - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
KW - Asian Continental Ancestry Group/genetics
KW - Educational Status
KW - Environment
KW - European Continental Ancestry Group/genetics
KW - Gene Expression Profiling
KW - Genetic Loci
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - Polymorphism, Single Nucleotide/genetics
KW - Refractive Errors/genetics
U2 - 10.1038/ncomms11008
DO - 10.1038/ncomms11008
M3 - SCORING: Journal article
C2 - 27020472
VL - 7
SP - 11008
JO - NAT COMMUN
JF - NAT COMMUN
SN - 2041-1723
ER -