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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

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Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. / Fan, Qiao; Verhoeven, Virginie J M; Wojciechowski, Robert; Barathi, Veluchamy A; Hysi, Pirro G; Guggenheim, Jeremy A; Höhn, René; Vitart, Veronique; Khawaja, Anthony P; Yamashiro, Kenji; Hosseini, S Mohsen; Lehtimäki, Terho; Lu, Yi; Haller, Toomas; Xie, Jing; Delcourt, Cécile; Pirastu, Mario; Wedenoja, Juho; Gharahkhani, Puya; Venturini, Cristina; Miyake, Masahiro; Hewitt, Alex W; Guo, Xiaobo; Mazur, Johanna; Huffman, Jenifer E; Williams, Katie M; Polasek, Ozren; Campbell, Harry; Rudan, Igor; Vatavuk, Zoran; Wilson, James F; Joshi, Peter K; McMahon, George; St Pourcain, Beate; Evans, David M; Simpson, Claire L; Schwantes-An, Tae-Hwi; Igo, Robert P; Mirshahi, Alireza; Cougnard-Gregoire, Audrey; Bellenguez, Céline; Blettner, Maria; Raitakari, Olli; Kähönen, Mika; Seppala, Ilkka; Zeller, Tanja; Meitinger, Thomas; Ried, Janina S; Gieger, Christian; Portas, Laura; van Leeuwen, Elisabeth M; Amin, Najaf; Uitterlinden, André G; Rivadeneira, Fernando; Hofman, Albert; Vingerling, Johannes R; Wang, Ya Xing; Wang, Xu; Tai-Hui Boh, Eileen; Ikram, M Kamran; Sabanayagam, Charumathi; Gupta, Preeti; Tan, Vincent; Zhou, Lei; Ho, Candice E H; Lim, Wan'e; Beuerman, Roger W; Siantar, Rosalynn; Tai, E-Shyong; Vithana, Eranga; Mihailov, Evelin; Khor, Chiea-Chuen; Hayward, Caroline; Luben, Robert N; Foster, Paul J; Klein, Barbara E K; Klein, Ronald; Wong, Hoi-Suen; Mitchell, Paul; Metspalu, Andres; Aung, Tin; Young, Terri L; He, Mingguang; Pärssinen, Olavi; van Duijn, Cornelia M; Jin Wang, Jie; Williams, Cathy; Jonas, Jost B; Teo, Yik-Ying; Mackey, David A; Oexle, Konrad; Yoshimura, Nagahisa; Paterson, Andrew D; Pfeiffer, Norbert; Wong, Tien-Yin; Baird, Paul N; Stambolian, Dwight; Wilson, Joan E Bailey; Cheng, Ching-Yu; Hammond, Christopher J; Klaver, Caroline C W; Saw, Seang-Mei; Rahi, Jugnoo S; Korobelnik, Jean-François; Kemp, John P; Timpson, Nicholas J; Smith, George Davey; Craig, Jamie E; Burdon, Kathryn P; Fogarty, Rhys D; Iyengar, Sudha K; Chew, Emily; Janmahasatian, Sarayut; Martin, Nicholas G; MacGregor, Stuart; Xu, Liang; Schache, Maria; Nangia, Vinay; Panda-Jonas, Songhomitra; Wright, Alan F; Fondran, Jeremy R; Lass, Jonathan H; Feng, Sheng; Zhao, Jing Hua; Khaw, Kay-Tee; Wareham, Nick J; Rantanen, Taina; Kaprio, Jaakko; Pang, Chi Pui; Chen, Li Jia; Tam, Pancy O; Jhanji, Vishal; Young, Alvin L; Döring, Angela; Raffel, Leslie J; Cotch, Mary-Frances; Li, Xiaohui; Yip, Shea Ping; Yap, Maurice K H; Biino, Ginevra; Vaccargiu, Simona; Fossarello, Maurizio; Fleck, Brian; Yazar, Seyhan; Tideman, Jan Willem L; Tedja, Milly; Deangelis, Margaret M; Morrison, Margaux; Farrer, Lindsay; Zhou, Xiangtian; Chen, Wei; Mizuki, Nobuhisa; Meguro, Akira; Mäkelä, Kari Matti; Consortium for Refractive Error and Myopia (CREAM).

in: NAT COMMUN, Jahrgang 7, 29.03.2016, S. 11008.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Fan, Q, Verhoeven, VJM, Wojciechowski, R, Barathi, VA, Hysi, PG, Guggenheim, JA, Höhn, R, Vitart, V, Khawaja, AP, Yamashiro, K, Hosseini, SM, Lehtimäki, T, Lu, Y, Haller, T, Xie, J, Delcourt, C, Pirastu, M, Wedenoja, J, Gharahkhani, P, Venturini, C, Miyake, M, Hewitt, AW, Guo, X, Mazur, J, Huffman, JE, Williams, KM, Polasek, O, Campbell, H, Rudan, I, Vatavuk, Z, Wilson, JF, Joshi, PK, McMahon, G, St Pourcain, B, Evans, DM, Simpson, CL, Schwantes-An, T-H, Igo, RP, Mirshahi, A, Cougnard-Gregoire, A, Bellenguez, C, Blettner, M, Raitakari, O, Kähönen, M, Seppala, I, Zeller, T, Meitinger, T, Ried, JS, Gieger, C, Portas, L, van Leeuwen, EM, Amin, N, Uitterlinden, AG, Rivadeneira, F, Hofman, A, Vingerling, JR, Wang, YX, Wang, X, Tai-Hui Boh, E, Ikram, MK, Sabanayagam, C, Gupta, P, Tan, V, Zhou, L, Ho, CEH, Lim, W, Beuerman, RW, Siantar, R, Tai, E-S, Vithana, E, Mihailov, E, Khor, C-C, Hayward, C, Luben, RN, Foster, PJ, Klein, BEK, Klein, R, Wong, H-S, Mitchell, P, Metspalu, A, Aung, T, Young, TL, He, M, Pärssinen, O, van Duijn, CM, Jin Wang, J, Williams, C, Jonas, JB, Teo, Y-Y, Mackey, DA, Oexle, K, Yoshimura, N, Paterson, AD, Pfeiffer, N, Wong, T-Y, Baird, PN, Stambolian, D, Wilson, JEB, Cheng, C-Y, Hammond, CJ, Klaver, CCW, Saw, S-M, Rahi, JS, Korobelnik, J-F, Kemp, JP, Timpson, NJ, Smith, GD, Craig, JE, Burdon, KP, Fogarty, RD, Iyengar, SK, Chew, E, Janmahasatian, S, Martin, NG, MacGregor, S, Xu, L, Schache, M, Nangia, V, Panda-Jonas, S, Wright, AF, Fondran, JR, Lass, JH, Feng, S, Zhao, JH, Khaw, K-T, Wareham, NJ, Rantanen, T, Kaprio, J, Pang, CP, Chen, LJ, Tam, PO, Jhanji, V, Young, AL, Döring, A, Raffel, LJ, Cotch, M-F, Li, X, Yip, SP, Yap, MKH, Biino, G, Vaccargiu, S, Fossarello, M, Fleck, B, Yazar, S, Tideman, JWL, Tedja, M, Deangelis, MM, Morrison, M, Farrer, L, Zhou, X, Chen, W, Mizuki, N, Meguro, A, Mäkelä, KM & Consortium for Refractive Error and Myopia (CREAM) 2016, 'Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error', NAT COMMUN, Jg. 7, S. 11008. https://doi.org/10.1038/ncomms11008

APA

Fan, Q., Verhoeven, V. J. M., Wojciechowski, R., Barathi, V. A., Hysi, P. G., Guggenheim, J. A., Höhn, R., Vitart, V., Khawaja, A. P., Yamashiro, K., Hosseini, S. M., Lehtimäki, T., Lu, Y., Haller, T., Xie, J., Delcourt, C., Pirastu, M., Wedenoja, J., Gharahkhani, P., ... Consortium for Refractive Error and Myopia (CREAM) (2016). Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. NAT COMMUN, 7, 11008. https://doi.org/10.1038/ncomms11008

Vancouver

Fan Q, Verhoeven VJM, Wojciechowski R, Barathi VA, Hysi PG, Guggenheim JA et al. Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error. NAT COMMUN. 2016 Mär 29;7:11008. https://doi.org/10.1038/ncomms11008

Bibtex

@article{570cdcf15cc048be9d60b73a9de973af,
title = "Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error",
abstract = "Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia. ",
keywords = "Asian Continental Ancestry Group/genetics, Educational Status, Environment, European Continental Ancestry Group/genetics, Gene Expression Profiling, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide/genetics, Refractive Errors/genetics",
author = "Qiao Fan and Verhoeven, {Virginie J M} and Robert Wojciechowski and Barathi, {Veluchamy A} and Hysi, {Pirro G} and Guggenheim, {Jeremy A} and Ren{\'e} H{\"o}hn and Veronique Vitart and Khawaja, {Anthony P} and Kenji Yamashiro and Hosseini, {S Mohsen} and Terho Lehtim{\"a}ki and Yi Lu and Toomas Haller and Jing Xie and C{\'e}cile Delcourt and Mario Pirastu and Juho Wedenoja and Puya Gharahkhani and Cristina Venturini and Masahiro Miyake and Hewitt, {Alex W} and Xiaobo Guo and Johanna Mazur and Huffman, {Jenifer E} and Williams, {Katie M} and Ozren Polasek and Harry Campbell and Igor Rudan and Zoran Vatavuk and Wilson, {James F} and Joshi, {Peter K} and George McMahon and {St Pourcain}, Beate and Evans, {David M} and Simpson, {Claire L} and Tae-Hwi Schwantes-An and Igo, {Robert P} and Alireza Mirshahi and Audrey Cougnard-Gregoire and C{\'e}line Bellenguez and Maria Blettner and Olli Raitakari and Mika K{\"a}h{\"o}nen and Ilkka Seppala and Tanja Zeller and Thomas Meitinger and Ried, {Janina S} and Christian Gieger and Laura Portas and {van Leeuwen}, {Elisabeth M} and Najaf Amin and Uitterlinden, {Andr{\'e} G} and Fernando Rivadeneira and Albert Hofman and Vingerling, {Johannes R} and Wang, {Ya Xing} and Xu Wang and {Tai-Hui Boh}, Eileen and Ikram, {M Kamran} and Charumathi Sabanayagam and Preeti Gupta and Vincent Tan and Lei Zhou and Ho, {Candice E H} and Wan'e Lim and Beuerman, {Roger W} and Rosalynn Siantar and E-Shyong Tai and Eranga Vithana and Evelin Mihailov and Chiea-Chuen Khor and Caroline Hayward and Luben, {Robert N} and Foster, {Paul J} and Klein, {Barbara E K} and Ronald Klein and Hoi-Suen Wong and Paul Mitchell and Andres Metspalu and Tin Aung and Young, {Terri L} and Mingguang He and Olavi P{\"a}rssinen and {van Duijn}, {Cornelia M} and {Jin Wang}, Jie and Cathy Williams and Jonas, {Jost B} and Yik-Ying Teo and Mackey, {David A} and Konrad Oexle and Nagahisa Yoshimura and Paterson, {Andrew D} and Norbert Pfeiffer and Tien-Yin Wong and Baird, {Paul N} and Dwight Stambolian and Wilson, {Joan E Bailey} and Ching-Yu Cheng and Hammond, {Christopher J} and Klaver, {Caroline C W} and Seang-Mei Saw and Rahi, {Jugnoo S} and Jean-Fran{\c c}ois Korobelnik and Kemp, {John P} and Timpson, {Nicholas J} and Smith, {George Davey} and Craig, {Jamie E} and Burdon, {Kathryn P} and Fogarty, {Rhys D} and Iyengar, {Sudha K} and Emily Chew and Sarayut Janmahasatian and Martin, {Nicholas G} and Stuart MacGregor and Liang Xu and Maria Schache and Vinay Nangia and Songhomitra Panda-Jonas and Wright, {Alan F} and Fondran, {Jeremy R} and Lass, {Jonathan H} and Sheng Feng and Zhao, {Jing Hua} and Kay-Tee Khaw and Wareham, {Nick J} and Taina Rantanen and Jaakko Kaprio and Pang, {Chi Pui} and Chen, {Li Jia} and Tam, {Pancy O} and Vishal Jhanji and Young, {Alvin L} and Angela D{\"o}ring and Raffel, {Leslie J} and Mary-Frances Cotch and Xiaohui Li and Yip, {Shea Ping} and Yap, {Maurice K H} and Ginevra Biino and Simona Vaccargiu and Maurizio Fossarello and Brian Fleck and Seyhan Yazar and Tideman, {Jan Willem L} and Milly Tedja and Deangelis, {Margaret M} and Margaux Morrison and Lindsay Farrer and Xiangtian Zhou and Wei Chen and Nobuhisa Mizuki and Akira Meguro and M{\"a}kel{\"a}, {Kari Matti} and {Consortium for Refractive Error and Myopia (CREAM)}",
year = "2016",
month = mar,
day = "29",
doi = "10.1038/ncomms11008",
language = "English",
volume = "7",
pages = "11008",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error

AU - Fan, Qiao

AU - Verhoeven, Virginie J M

AU - Wojciechowski, Robert

AU - Barathi, Veluchamy A

AU - Hysi, Pirro G

AU - Guggenheim, Jeremy A

AU - Höhn, René

AU - Vitart, Veronique

AU - Khawaja, Anthony P

AU - Yamashiro, Kenji

AU - Hosseini, S Mohsen

AU - Lehtimäki, Terho

AU - Lu, Yi

AU - Haller, Toomas

AU - Xie, Jing

AU - Delcourt, Cécile

AU - Pirastu, Mario

AU - Wedenoja, Juho

AU - Gharahkhani, Puya

AU - Venturini, Cristina

AU - Miyake, Masahiro

AU - Hewitt, Alex W

AU - Guo, Xiaobo

AU - Mazur, Johanna

AU - Huffman, Jenifer E

AU - Williams, Katie M

AU - Polasek, Ozren

AU - Campbell, Harry

AU - Rudan, Igor

AU - Vatavuk, Zoran

AU - Wilson, James F

AU - Joshi, Peter K

AU - McMahon, George

AU - St Pourcain, Beate

AU - Evans, David M

AU - Simpson, Claire L

AU - Schwantes-An, Tae-Hwi

AU - Igo, Robert P

AU - Mirshahi, Alireza

AU - Cougnard-Gregoire, Audrey

AU - Bellenguez, Céline

AU - Blettner, Maria

AU - Raitakari, Olli

AU - Kähönen, Mika

AU - Seppala, Ilkka

AU - Zeller, Tanja

AU - Meitinger, Thomas

AU - Ried, Janina S

AU - Gieger, Christian

AU - Portas, Laura

AU - van Leeuwen, Elisabeth M

AU - Amin, Najaf

AU - Uitterlinden, André G

AU - Rivadeneira, Fernando

AU - Hofman, Albert

AU - Vingerling, Johannes R

AU - Wang, Ya Xing

AU - Wang, Xu

AU - Tai-Hui Boh, Eileen

AU - Ikram, M Kamran

AU - Sabanayagam, Charumathi

AU - Gupta, Preeti

AU - Tan, Vincent

AU - Zhou, Lei

AU - Ho, Candice E H

AU - Lim, Wan'e

AU - Beuerman, Roger W

AU - Siantar, Rosalynn

AU - Tai, E-Shyong

AU - Vithana, Eranga

AU - Mihailov, Evelin

AU - Khor, Chiea-Chuen

AU - Hayward, Caroline

AU - Luben, Robert N

AU - Foster, Paul J

AU - Klein, Barbara E K

AU - Klein, Ronald

AU - Wong, Hoi-Suen

AU - Mitchell, Paul

AU - Metspalu, Andres

AU - Aung, Tin

AU - Young, Terri L

AU - He, Mingguang

AU - Pärssinen, Olavi

AU - van Duijn, Cornelia M

AU - Jin Wang, Jie

AU - Williams, Cathy

AU - Jonas, Jost B

AU - Teo, Yik-Ying

AU - Mackey, David A

AU - Oexle, Konrad

AU - Yoshimura, Nagahisa

AU - Paterson, Andrew D

AU - Pfeiffer, Norbert

AU - Wong, Tien-Yin

AU - Baird, Paul N

AU - Stambolian, Dwight

AU - Wilson, Joan E Bailey

AU - Cheng, Ching-Yu

AU - Hammond, Christopher J

AU - Klaver, Caroline C W

AU - Saw, Seang-Mei

AU - Rahi, Jugnoo S

AU - Korobelnik, Jean-François

AU - Kemp, John P

AU - Timpson, Nicholas J

AU - Smith, George Davey

AU - Craig, Jamie E

AU - Burdon, Kathryn P

AU - Fogarty, Rhys D

AU - Iyengar, Sudha K

AU - Chew, Emily

AU - Janmahasatian, Sarayut

AU - Martin, Nicholas G

AU - MacGregor, Stuart

AU - Xu, Liang

AU - Schache, Maria

AU - Nangia, Vinay

AU - Panda-Jonas, Songhomitra

AU - Wright, Alan F

AU - Fondran, Jeremy R

AU - Lass, Jonathan H

AU - Feng, Sheng

AU - Zhao, Jing Hua

AU - Khaw, Kay-Tee

AU - Wareham, Nick J

AU - Rantanen, Taina

AU - Kaprio, Jaakko

AU - Pang, Chi Pui

AU - Chen, Li Jia

AU - Tam, Pancy O

AU - Jhanji, Vishal

AU - Young, Alvin L

AU - Döring, Angela

AU - Raffel, Leslie J

AU - Cotch, Mary-Frances

AU - Li, Xiaohui

AU - Yip, Shea Ping

AU - Yap, Maurice K H

AU - Biino, Ginevra

AU - Vaccargiu, Simona

AU - Fossarello, Maurizio

AU - Fleck, Brian

AU - Yazar, Seyhan

AU - Tideman, Jan Willem L

AU - Tedja, Milly

AU - Deangelis, Margaret M

AU - Morrison, Margaux

AU - Farrer, Lindsay

AU - Zhou, Xiangtian

AU - Chen, Wei

AU - Mizuki, Nobuhisa

AU - Meguro, Akira

AU - Mäkelä, Kari Matti

AU - Consortium for Refractive Error and Myopia (CREAM)

PY - 2016/3/29

Y1 - 2016/3/29

N2 - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

AB - Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

KW - Asian Continental Ancestry Group/genetics

KW - Educational Status

KW - Environment

KW - European Continental Ancestry Group/genetics

KW - Gene Expression Profiling

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Polymorphism, Single Nucleotide/genetics

KW - Refractive Errors/genetics

U2 - 10.1038/ncomms11008

DO - 10.1038/ncomms11008

M3 - SCORING: Journal article

C2 - 27020472

VL - 7

SP - 11008

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -