Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity
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Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity. / Leshchenko, Elena V; Antonov, Alexandr S; Dyshlovoy, Sergey A; Berdyshev, Dmitrii V; Hauschild, Jessica; Zhuravleva, Olesya I; Menshov, Alexander S; Kirichuk, Natalya N; Popov, Roman S; Gerasimenko, Andrey V; Udovenko, Anatoly A; Graefen, Markus; Bokemeyer, Carsten; von Amsberg, Gunhild; Yurchenko, Anton N.
In: J NAT PROD, Vol. 85, No. 12, 23.12.2022, p. 2746-2752.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Meroantarctines A-C, Meroterpenoids with Rearranged Skeletons from the Alga-Derived Fungus Penicillium antarcticum KMM 4685 with Potent p-Glycoprotein Inhibitory Activity
AU - Leshchenko, Elena V
AU - Antonov, Alexandr S
AU - Dyshlovoy, Sergey A
AU - Berdyshev, Dmitrii V
AU - Hauschild, Jessica
AU - Zhuravleva, Olesya I
AU - Menshov, Alexander S
AU - Kirichuk, Natalya N
AU - Popov, Roman S
AU - Gerasimenko, Andrey V
AU - Udovenko, Anatoly A
AU - Graefen, Markus
AU - Bokemeyer, Carsten
AU - von Amsberg, Gunhild
AU - Yurchenko, Anton N
PY - 2022/12/23
Y1 - 2022/12/23
N2 - New meroterpenoids, meroantarctines A-C (1-3), with unique 6/5/6/6, 6/5/6/5/6, and 6/5/6/5 polycyclic systems were isolated from the alga-derived fungus Penicillium antarcticum KMM 4685. Their structures were elucidated by spectroscopic methods, X-ray diffraction, and quantum chemical calculations. A biogenetic pathway for 1-3 was proposed. Meroantarctines A-C (1-3) inhibited p-glycoprotein activity and could resensitize drug-resistant cancer cells to docetaxel.
AB - New meroterpenoids, meroantarctines A-C (1-3), with unique 6/5/6/6, 6/5/6/5/6, and 6/5/6/5 polycyclic systems were isolated from the alga-derived fungus Penicillium antarcticum KMM 4685. Their structures were elucidated by spectroscopic methods, X-ray diffraction, and quantum chemical calculations. A biogenetic pathway for 1-3 was proposed. Meroantarctines A-C (1-3) inhibited p-glycoprotein activity and could resensitize drug-resistant cancer cells to docetaxel.
U2 - 10.1021/acs.jnatprod.2c00677
DO - 10.1021/acs.jnatprod.2c00677
M3 - SCORING: Journal article
C2 - 36413729
VL - 85
SP - 2746
EP - 2752
JO - J NAT PROD
JF - J NAT PROD
SN - 0163-3864
IS - 12
ER -