Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential
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Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential. / Grundhoff, Adam; Fischer, Nicole.
In: CURR OPIN VIROL, Vol. 14, 05.10.2015, p. 129-137.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential
AU - Grundhoff, Adam
AU - Fischer, Nicole
N1 - Copyright © 2015 Elsevier B.V. All rights reserved.
PY - 2015/10/5
Y1 - 2015/10/5
N2 - Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided significant details regarding molecular functions of viral oncoproteins during cellular transformation, many open questions about the natural life cycle of the virus, its mechanisms of persistence and the precise role of MCPyV during MCC pathogenesis remain. This review will carve out the specifics of MCPyV biology and discuss unresolved issues to help the reader gain a better understanding of what may differentiate MCPyV from other polyomaviruses.
AB - Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided significant details regarding molecular functions of viral oncoproteins during cellular transformation, many open questions about the natural life cycle of the virus, its mechanisms of persistence and the precise role of MCPyV during MCC pathogenesis remain. This review will carve out the specifics of MCPyV biology and discuss unresolved issues to help the reader gain a better understanding of what may differentiate MCPyV from other polyomaviruses.
U2 - 10.1016/j.coviro.2015.08.010
DO - 10.1016/j.coviro.2015.08.010
M3 - SCORING: Journal article
C2 - 26447560
VL - 14
SP - 129
EP - 137
JO - CURR OPIN VIROL
JF - CURR OPIN VIROL
SN - 1879-6257
ER -