Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential

Adam Grundhoff; Nicole Fischer

doi:10.1016/j.coviro.2015.08.010

Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential

Standard

Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential. / Grundhoff, Adam; Fischer, Nicole.

in: CURR OPIN VIROL, Jahrgang 14, 05.10.2015, S. 129-137.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Grundhoff, A & Fischer, N 2015, 'Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential', CURR OPIN VIROL, Jg. 14, S. 129-137. https://doi.org/10.1016/j.coviro.2015.08.010

APA

Grundhoff, A., & Fischer, N. (2015). Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential. CURR OPIN VIROL, 14, 129-137. https://doi.org/10.1016/j.coviro.2015.08.010

Vancouver

Grundhoff A, Fischer N. Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential. CURR OPIN VIROL. 2015 Okt 5;14:129-137. https://doi.org/10.1016/j.coviro.2015.08.010

Bibtex

@article{5934bd5cffb64214989322837158ba70,

title = "Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential",

abstract = "Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided significant details regarding molecular functions of viral oncoproteins during cellular transformation, many open questions about the natural life cycle of the virus, its mechanisms of persistence and the precise role of MCPyV during MCC pathogenesis remain. This review will carve out the specifics of MCPyV biology and discuss unresolved issues to help the reader gain a better understanding of what may differentiate MCPyV from other polyomaviruses.",

author = "Adam Grundhoff and Nicole Fischer",

year = "2015",

month = oct,

day = "5",

doi = "10.1016/j.coviro.2015.08.010",

language = "English",

volume = "14",

pages = "129--137",

journal = "CURR OPIN VIROL",

issn = "1879-6257",

publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Merkel cell polyomavirus, a highly prevalent virus with tumorigenic potential

AU - Grundhoff, Adam

AU - Fischer, Nicole

PY - 2015/10/5

Y1 - 2015/10/5

N2 - Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided significant details regarding molecular functions of viral oncoproteins during cellular transformation, many open questions about the natural life cycle of the virus, its mechanisms of persistence and the precise role of MCPyV during MCC pathogenesis remain. This review will carve out the specifics of MCPyV biology and discuss unresolved issues to help the reader gain a better understanding of what may differentiate MCPyV from other polyomaviruses.

AB - Merkel cell polyomavirus (MCPyV) is the only human polyomavirus known to be involved in tumorigenesis. Like other human polyomaviruses, MCPyV is highly prevalent in the healthy population, yet the MCPyV-associated Merkel cell carcinoma (MCC) is a very rare disease. Although in vitro and in vivo models have provided significant details regarding molecular functions of viral oncoproteins during cellular transformation, many open questions about the natural life cycle of the virus, its mechanisms of persistence and the precise role of MCPyV during MCC pathogenesis remain. This review will carve out the specifics of MCPyV biology and discuss unresolved issues to help the reader gain a better understanding of what may differentiate MCPyV from other polyomaviruses.

U2 - 10.1016/j.coviro.2015.08.010

DO - 10.1016/j.coviro.2015.08.010

M3 - SCORING: Journal article

C2 - 26447560

VL - 14

SP - 129

EP - 137

JO - CURR OPIN VIROL

JF - CURR OPIN VIROL

SN - 1879-6257

ER -