Maternal microchimerism: lessons learned from murine models.
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Maternal microchimerism: lessons learned from murine models. / Stelzer, Ina; Thiele, Kristin; Solano, Maria Emilia.
In: J REPROD IMMUNOL, Vol. 108, No. SI, 04.2015, p. 12-25.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Maternal microchimerism: lessons learned from murine models.
AU - Stelzer, Ina
AU - Thiele, Kristin
AU - Solano, Maria Emilia
PY - 2015/4
Y1 - 2015/4
N2 - The presence of maternal cells in the organs of the offspring is referred to as maternal microchimerism (MMc). MMc is physiologically acquired during pregnancy and lactation and can persist until adulthood. The detection of MMc in a variety of human diseases has raised interest in the short- and long-term functional consequences for the offspring. Owing to limited availability and access to human tissue, mouse models have become an essential tool in elucidating the functional role of MMc. This review compiles the detection techniques and experimental settings used in murine MMc research. It aims to summarize the potential mechanisms of migration of MMc, pre- and postnatal tissue distribution, phenotype and concatenated function, as well as factors modulating its occurrence. In this context, we propose MMc to be a materno-fetal messenger with the capacity to critically shape the development of the offspring's immunity.
AB - The presence of maternal cells in the organs of the offspring is referred to as maternal microchimerism (MMc). MMc is physiologically acquired during pregnancy and lactation and can persist until adulthood. The detection of MMc in a variety of human diseases has raised interest in the short- and long-term functional consequences for the offspring. Owing to limited availability and access to human tissue, mouse models have become an essential tool in elucidating the functional role of MMc. This review compiles the detection techniques and experimental settings used in murine MMc research. It aims to summarize the potential mechanisms of migration of MMc, pre- and postnatal tissue distribution, phenotype and concatenated function, as well as factors modulating its occurrence. In this context, we propose MMc to be a materno-fetal messenger with the capacity to critically shape the development of the offspring's immunity.
U2 - 10.1016/j.jri.2014.12.007.
DO - 10.1016/j.jri.2014.12.007.
M3 - SCORING: Journal article
VL - 108
SP - 12
EP - 25
JO - J REPROD IMMUNOL
JF - J REPROD IMMUNOL
SN - 0165-0378
IS - SI
ER -