Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring
Standard
Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring. / Oelkrug, Rebecca; Krause, Christin; Herrmann, Beate; Resch, Julia; Gachkar, Sogol; El Gammal, Alexander T; Wolter, Stefan; Mann, Oliver; Oster, Henrik; Kirchner, Henriette; Mittag, Jens.
In: CELL REP, Vol. 33, No. 5, 03.11.2020, p. 108351.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring
AU - Oelkrug, Rebecca
AU - Krause, Christin
AU - Herrmann, Beate
AU - Resch, Julia
AU - Gachkar, Sogol
AU - El Gammal, Alexander T
AU - Wolter, Stefan
AU - Mann, Oliver
AU - Oster, Henrik
AU - Kirchner, Henriette
AU - Mittag, Jens
N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
PY - 2020/11/3
Y1 - 2020/11/3
N2 - Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal thermogenesis alter the metabolic phenotype already in the next generation. Male offspring of mothers genetically lacking brown adipose tissue (BAT) thermogenesis display increased lean mass and improved glucose tolerance as adults, while females are unaffected. The phenotype is replicated in offspring of mothers kept at thermoneutrality; conversely, mothers with higher gestational BAT thermogenesis produce male offspring with reduced lean mass and impaired glucose tolerance. Running-wheel exercise reverses the offspring's metabolic impairments, pointing to the muscle as target of these fetal programming effects. Our data demonstrate that gestational BAT activation negatively affects metabolic health of the male offspring; however, these unfavorable fetal programming effects may be negated by active lifestyle.
AB - Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal thermogenesis alter the metabolic phenotype already in the next generation. Male offspring of mothers genetically lacking brown adipose tissue (BAT) thermogenesis display increased lean mass and improved glucose tolerance as adults, while females are unaffected. The phenotype is replicated in offspring of mothers kept at thermoneutrality; conversely, mothers with higher gestational BAT thermogenesis produce male offspring with reduced lean mass and impaired glucose tolerance. Running-wheel exercise reverses the offspring's metabolic impairments, pointing to the muscle as target of these fetal programming effects. Our data demonstrate that gestational BAT activation negatively affects metabolic health of the male offspring; however, these unfavorable fetal programming effects may be negated by active lifestyle.
U2 - 10.1016/j.celrep.2020.108351
DO - 10.1016/j.celrep.2020.108351
M3 - SCORING: Journal article
C2 - 33147454
VL - 33
SP - 108351
JO - CELL REP
JF - CELL REP
SN - 2211-1247
IS - 5
ER -