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Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

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Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring. / Oelkrug, Rebecca; Krause, Christin; Herrmann, Beate; Resch, Julia; Gachkar, Sogol; El Gammal, Alexander T; Wolter, Stefan; Mann, Oliver; Oster, Henrik; Kirchner, Henriette; Mittag, Jens.

in: CELL REP, Jahrgang 33, Nr. 5, 03.11.2020, S. 108351.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Oelkrug, R, Krause, C, Herrmann, B, Resch, J, Gachkar, S, El Gammal, AT, Wolter, S, Mann, O, Oster, H, Kirchner, H & Mittag, J 2020, 'Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring', CELL REP, Jg. 33, Nr. 5, S. 108351. https://doi.org/10.1016/j.celrep.2020.108351

APA

Oelkrug, R., Krause, C., Herrmann, B., Resch, J., Gachkar, S., El Gammal, A. T., Wolter, S., Mann, O., Oster, H., Kirchner, H., & Mittag, J. (2020). Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring. CELL REP, 33(5), 108351. https://doi.org/10.1016/j.celrep.2020.108351

Vancouver

Oelkrug R, Krause C, Herrmann B, Resch J, Gachkar S, El Gammal AT et al. Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring. CELL REP. 2020 Nov 3;33(5):108351. https://doi.org/10.1016/j.celrep.2020.108351

Bibtex

@article{8b481fd4e64e4852aec9b8dc9344c9f4,
title = "Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring",
abstract = "Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal thermogenesis alter the metabolic phenotype already in the next generation. Male offspring of mothers genetically lacking brown adipose tissue (BAT) thermogenesis display increased lean mass and improved glucose tolerance as adults, while females are unaffected. The phenotype is replicated in offspring of mothers kept at thermoneutrality; conversely, mothers with higher gestational BAT thermogenesis produce male offspring with reduced lean mass and impaired glucose tolerance. Running-wheel exercise reverses the offspring's metabolic impairments, pointing to the muscle as target of these fetal programming effects. Our data demonstrate that gestational BAT activation negatively affects metabolic health of the male offspring; however, these unfavorable fetal programming effects may be negated by active lifestyle.",
author = "Rebecca Oelkrug and Christin Krause and Beate Herrmann and Julia Resch and Sogol Gachkar and {El Gammal}, {Alexander T} and Stefan Wolter and Oliver Mann and Henrik Oster and Henriette Kirchner and Jens Mittag",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = nov,
day = "3",
doi = "10.1016/j.celrep.2020.108351",
language = "English",
volume = "33",
pages = "108351",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

AU - Oelkrug, Rebecca

AU - Krause, Christin

AU - Herrmann, Beate

AU - Resch, Julia

AU - Gachkar, Sogol

AU - El Gammal, Alexander T

AU - Wolter, Stefan

AU - Mann, Oliver

AU - Oster, Henrik

AU - Kirchner, Henriette

AU - Mittag, Jens

N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020/11/3

Y1 - 2020/11/3

N2 - Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal thermogenesis alter the metabolic phenotype already in the next generation. Male offspring of mothers genetically lacking brown adipose tissue (BAT) thermogenesis display increased lean mass and improved glucose tolerance as adults, while females are unaffected. The phenotype is replicated in offspring of mothers kept at thermoneutrality; conversely, mothers with higher gestational BAT thermogenesis produce male offspring with reduced lean mass and impaired glucose tolerance. Running-wheel exercise reverses the offspring's metabolic impairments, pointing to the muscle as target of these fetal programming effects. Our data demonstrate that gestational BAT activation negatively affects metabolic health of the male offspring; however, these unfavorable fetal programming effects may be negated by active lifestyle.

AB - Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection. Here, we show in mice that even minor changes in maternal thermogenesis alter the metabolic phenotype already in the next generation. Male offspring of mothers genetically lacking brown adipose tissue (BAT) thermogenesis display increased lean mass and improved glucose tolerance as adults, while females are unaffected. The phenotype is replicated in offspring of mothers kept at thermoneutrality; conversely, mothers with higher gestational BAT thermogenesis produce male offspring with reduced lean mass and impaired glucose tolerance. Running-wheel exercise reverses the offspring's metabolic impairments, pointing to the muscle as target of these fetal programming effects. Our data demonstrate that gestational BAT activation negatively affects metabolic health of the male offspring; however, these unfavorable fetal programming effects may be negated by active lifestyle.

U2 - 10.1016/j.celrep.2020.108351

DO - 10.1016/j.celrep.2020.108351

M3 - SCORING: Journal article

C2 - 33147454

VL - 33

SP - 108351

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 5

ER -