Management of acute haemarthrosis in haemophilia A without inhibitors: literature review, European survey and recommendations.
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Management of acute haemarthrosis in haemophilia A without inhibitors: literature review, European survey and recommendations. / Hermans, C; De Moerloose, P; Fischer, K; Holstein, Katharina; Klamroth, R; Lambert, T; Lavigne-Lissalde, G; Perez, R; Richards, M; Dolan, G; Board, European Haemophilia Therapy Standardisation.
In: HAEMOPHILIA, Vol. 17, No. 3, 3, 2011, p. 383-392.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Management of acute haemarthrosis in haemophilia A without inhibitors: literature review, European survey and recommendations.
AU - Hermans, C
AU - De Moerloose, P
AU - Fischer, K
AU - Holstein, Katharina
AU - Klamroth, R
AU - Lambert, T
AU - Lavigne-Lissalde, G
AU - Perez, R
AU - Richards, M
AU - Dolan, G
AU - Board, European Haemophilia Therapy Standardisation
PY - 2011
Y1 - 2011
N2 - Acute haemarthrosis is a frequent type of bleeding in individuals with haemophilia. Delayed and/or inadequate treatment can trigger a series of pathological changes within the joint, leading to a painful and disabling arthropathy. The early management of intra-articular bleeding has the potential to prevent chronic joint disease and may include a combination of factor replacement, rest, ice, rehabilitation and, in certain cases, joint aspiration. Little data are, however, available regarding the optimal management of acute haemarthrosis, especially with respect to replacement therapy and the use of adjunctive therapies (aspiration, avoidance of weight bearing and immobilization, as well as the use of anti-inflammatory medication and embolization). To provide more insight into the management of acute haemarthrosis in patients with haemophilia, a literature review was conducted. Concomitantly, current management was surveyed in 26 European haemophilia comprehensive care centres representing 15 different countries. The review highlights the need for future robust studies to better define the appropriate replacement therapy and the role of adjunctive therapies such as aspiration. The survey reveals much heterogeneity in the management of acute haemarthrosis across the EU. Within the constraints discussed, treatment recommendations are presented that reflect the literature, current practice and the clinical experience of the European Haemophilia Therapy Standardisation Board (EHTSB).
AB - Acute haemarthrosis is a frequent type of bleeding in individuals with haemophilia. Delayed and/or inadequate treatment can trigger a series of pathological changes within the joint, leading to a painful and disabling arthropathy. The early management of intra-articular bleeding has the potential to prevent chronic joint disease and may include a combination of factor replacement, rest, ice, rehabilitation and, in certain cases, joint aspiration. Little data are, however, available regarding the optimal management of acute haemarthrosis, especially with respect to replacement therapy and the use of adjunctive therapies (aspiration, avoidance of weight bearing and immobilization, as well as the use of anti-inflammatory medication and embolization). To provide more insight into the management of acute haemarthrosis in patients with haemophilia, a literature review was conducted. Concomitantly, current management was surveyed in 26 European haemophilia comprehensive care centres representing 15 different countries. The review highlights the need for future robust studies to better define the appropriate replacement therapy and the role of adjunctive therapies such as aspiration. The survey reveals much heterogeneity in the management of acute haemarthrosis across the EU. Within the constraints discussed, treatment recommendations are presented that reflect the literature, current practice and the clinical experience of the European Haemophilia Therapy Standardisation Board (EHTSB).
KW - Adult
KW - Humans
KW - Practice Guidelines as Topic
KW - Europe
KW - Child
KW - Acute Disease
KW - Blood Coagulation Factors/administration & dosage
KW - Hemarthrosis/prevention & control/therapy
KW - Hemophilia A/therapy
KW - Pain Management
KW - Physical Therapy Modalities
KW - Adult
KW - Humans
KW - Practice Guidelines as Topic
KW - Europe
KW - Child
KW - Acute Disease
KW - Blood Coagulation Factors/administration & dosage
KW - Hemarthrosis/prevention & control/therapy
KW - Hemophilia A/therapy
KW - Pain Management
KW - Physical Therapy Modalities
M3 - SCORING: Journal article
VL - 17
SP - 383
EP - 392
JO - HAEMOPHILIA
JF - HAEMOPHILIA
SN - 1351-8216
IS - 3
M1 - 3
ER -
