Research ExplorerPublicationsMalignant transformation of mouse M2-fibroblasts by glycerol...

Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.

Standard

Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. / Piasecki, Angelika; Ruge, A; Marquardt, H.

In: ARZNEIMITTEL-FORSCH, Vol. 40, No. 9, 9, 1990, p. 1054-1055.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Piasecki, A, Ruge, A & Marquardt, H 1990, 'Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.', ARZNEIMITTEL-FORSCH, vol. 40, no. 9, 9, pp. 1054-1055. <http://www.ncbi.nlm.nih.gov/pubmed/2080943?dopt=Citation>

APA

Piasecki, A., Ruge, A., & Marquardt, H. (1990). Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. ARZNEIMITTEL-FORSCH, 40(9), 1054-1055. [9]. http://www.ncbi.nlm.nih.gov/pubmed/2080943?dopt=Citation

Vancouver

Piasecki A, Ruge A, Marquardt H. Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. ARZNEIMITTEL-FORSCH. 1990;40(9):1054-1055. 9.

Bibtex

@article{c3b1bca2b11e497194c0b0e3fca92446,
title = "Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.",
abstract = "Glycerol chlorohydrines, such as 3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol, are present in commercial protein hydrolysates used for human nutrition. These compounds are genotoxic and 1,3-dichloro-2-propanol induced tumors in rats. Now it is reported that both compounds are active at inducing malignant transformation of mouse fibroblasts. Therefore, the carcinogenic risk to humans by exposure to these compounds contained in food is of concern. The investigation of the in vivo carcinogenic potential of 3-chloro-1,2-propanediol is urgently required to further evaluate the carcinogenic risk to exposed consumers.",
keywords = "Animals, Male, Mice, Cell Line, Mice, Inbred C3H, Cell Transformation, Neoplastic/*drug effects, *Carcinogens, Fibroblasts/drug effects, Food Contamination/*analysis, Protein Hydrolysates/*chemistry, alpha-Chlorohydrin/*analogs & derivatives/*toxicity, Animals, Male, Mice, Cell Line, Mice, Inbred C3H, Cell Transformation, Neoplastic/*drug effects, *Carcinogens, Fibroblasts/drug effects, Food Contamination/*analysis, Protein Hydrolysates/*chemistry, alpha-Chlorohydrin/*analogs & derivatives/*toxicity",
author = "Angelika Piasecki and A Ruge and H Marquardt",
year = "1990",
language = "English",
volume = "40",
pages = "1054--1055",
number = "9",

}

RIS

TY - JOUR

T1 - Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.

AU - Piasecki, Angelika

AU - Ruge, A

AU - Marquardt, H

PY - 1990

Y1 - 1990

N2 - Glycerol chlorohydrines, such as 3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol, are present in commercial protein hydrolysates used for human nutrition. These compounds are genotoxic and 1,3-dichloro-2-propanol induced tumors in rats. Now it is reported that both compounds are active at inducing malignant transformation of mouse fibroblasts. Therefore, the carcinogenic risk to humans by exposure to these compounds contained in food is of concern. The investigation of the in vivo carcinogenic potential of 3-chloro-1,2-propanediol is urgently required to further evaluate the carcinogenic risk to exposed consumers.

AB - Glycerol chlorohydrines, such as 3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol, are present in commercial protein hydrolysates used for human nutrition. These compounds are genotoxic and 1,3-dichloro-2-propanol induced tumors in rats. Now it is reported that both compounds are active at inducing malignant transformation of mouse fibroblasts. Therefore, the carcinogenic risk to humans by exposure to these compounds contained in food is of concern. The investigation of the in vivo carcinogenic potential of 3-chloro-1,2-propanediol is urgently required to further evaluate the carcinogenic risk to exposed consumers.

KW - Animals

KW - Male

KW - Mice

KW - Cell Line

KW - Mice, Inbred C3H

KW - Cell Transformation, Neoplastic/drug effects

KW - Carcinogens

KW - Fibroblasts/drug effects

KW - Food Contamination/analysis

KW - Protein Hydrolysates/chemistry

KW - alpha-Chlorohydrin/analogs & derivatives/toxicity

KW - Animals

KW - Male

KW - Mice

KW - Cell Line

KW - Mice, Inbred C3H

KW - Cell Transformation, Neoplastic/drug effects

KW - Carcinogens

KW - Fibroblasts/drug effects

KW - Food Contamination/analysis

KW - Protein Hydrolysates/chemistry

KW - alpha-Chlorohydrin/analogs & derivatives/toxicity

M3 - SCORING: Journal article

VL - 40

SP - 1054

EP - 1055

IS - 9

M1 - 9

ER -