Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.
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Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food. / Piasecki, Angelika; Ruge, A; Marquardt, H.
in: ARZNEIMITTEL-FORSCH, Jahrgang 40, Nr. 9, 9, 1990, S. 1054-1055.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Malignant transformation of mouse M2-fibroblasts by glycerol chlorohydrines contained in protein hydrolysates and commercial food.
AU - Piasecki, Angelika
AU - Ruge, A
AU - Marquardt, H
PY - 1990
Y1 - 1990
N2 - Glycerol chlorohydrines, such as 3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol, are present in commercial protein hydrolysates used for human nutrition. These compounds are genotoxic and 1,3-dichloro-2-propanol induced tumors in rats. Now it is reported that both compounds are active at inducing malignant transformation of mouse fibroblasts. Therefore, the carcinogenic risk to humans by exposure to these compounds contained in food is of concern. The investigation of the in vivo carcinogenic potential of 3-chloro-1,2-propanediol is urgently required to further evaluate the carcinogenic risk to exposed consumers.
AB - Glycerol chlorohydrines, such as 3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol, are present in commercial protein hydrolysates used for human nutrition. These compounds are genotoxic and 1,3-dichloro-2-propanol induced tumors in rats. Now it is reported that both compounds are active at inducing malignant transformation of mouse fibroblasts. Therefore, the carcinogenic risk to humans by exposure to these compounds contained in food is of concern. The investigation of the in vivo carcinogenic potential of 3-chloro-1,2-propanediol is urgently required to further evaluate the carcinogenic risk to exposed consumers.
KW - Animals
KW - Male
KW - Mice
KW - Cell Line
KW - Mice, Inbred C3H
KW - Cell Transformation, Neoplastic/drug effects
KW - Carcinogens
KW - Fibroblasts/drug effects
KW - Food Contamination/analysis
KW - Protein Hydrolysates/chemistry
KW - alpha-Chlorohydrin/analogs & derivatives/toxicity
KW - Animals
KW - Male
KW - Mice
KW - Cell Line
KW - Mice, Inbred C3H
KW - Cell Transformation, Neoplastic/drug effects
KW - Carcinogens
KW - Fibroblasts/drug effects
KW - Food Contamination/analysis
KW - Protein Hydrolysates/chemistry
KW - alpha-Chlorohydrin/analogs & derivatives/toxicity
M3 - SCORING: Journal article
VL - 40
SP - 1054
EP - 1055
IS - 9
M1 - 9
ER -