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Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

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Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood. / Stanelle-Bertram, Stephanie; Walendy-Gnirß, Kerstin; Speiseder, Thomas; Thiele, Swantje; Asante, Ivy Asantewaa; Dreier, Carola; Kouassi, Nancy Mounogou; Preuß, Annette; Pilnitz-Stolze, Gundula; Müller, Ursula; Thanisch, Stefanie; Richter, Melanie; Scharrenberg, Robin; Kraus, Vanessa; Dörk, Ronja; Schau, Lynn; Herder, Vanessa; Gerhauser, Ingo; Pfankuche, Vanessa Maria; Käufer, Christopher; Waltl, Inken; Moraes, Thais; Sellau, Julie; Hoenow, Stefan; Schmidt-Chanasit, Jonas; Jansen, Stephanie; Schattling, Benjamin; Ittrich, Harald; Bartsch, Udo; Renné, Thomas; Bartenschlager, Ralf; Arck, Petra; Cadar, Daniel; Friese, Manuel A; Vapalahti, Olli; Lotter, Hanna; Benites, Sany; Rolling, Lane; Gabriel, Martin; Baumgärtner, Wolfgang; Morellini, Fabio; Hölter, Sabine M; Amarie, Oana; Fuchs, Helmut; Hrabe de Angelis, Martin; Löscher, Wolfgang; Calderon de Anda, Froylan; Gabriel, Gülsah.

In: NAT MICROBIOL, Vol. 3, No. 10, 10.2018, p. 1161-1174.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Stanelle-Bertram, S, Walendy-Gnirß, K, Speiseder, T, Thiele, S, Asante, IA, Dreier, C, Kouassi, NM, Preuß, A, Pilnitz-Stolze, G, Müller, U, Thanisch, S, Richter, M, Scharrenberg, R, Kraus, V, Dörk, R, Schau, L, Herder, V, Gerhauser, I, Pfankuche, VM, Käufer, C, Waltl, I, Moraes, T, Sellau, J, Hoenow, S, Schmidt-Chanasit, J, Jansen, S, Schattling, B, Ittrich, H, Bartsch, U, Renné, T, Bartenschlager, R, Arck, P, Cadar, D, Friese, MA, Vapalahti, O, Lotter, H, Benites, S, Rolling, L, Gabriel, M, Baumgärtner, W, Morellini, F, Hölter, SM, Amarie, O, Fuchs, H, Hrabe de Angelis, M, Löscher, W, Calderon de Anda, F & Gabriel, G 2018, 'Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood', NAT MICROBIOL, vol. 3, no. 10, pp. 1161-1174. https://doi.org/10.1038/s41564-018-0236-1

APA

Stanelle-Bertram, S., Walendy-Gnirß, K., Speiseder, T., Thiele, S., Asante, I. A., Dreier, C., Kouassi, N. M., Preuß, A., Pilnitz-Stolze, G., Müller, U., Thanisch, S., Richter, M., Scharrenberg, R., Kraus, V., Dörk, R., Schau, L., Herder, V., Gerhauser, I., Pfankuche, V. M., ... Gabriel, G. (2018). Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood. NAT MICROBIOL, 3(10), 1161-1174. https://doi.org/10.1038/s41564-018-0236-1

Vancouver

Stanelle-Bertram S, Walendy-Gnirß K, Speiseder T, Thiele S, Asante IA, Dreier C et al. Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood. NAT MICROBIOL. 2018 Oct;3(10):1161-1174. https://doi.org/10.1038/s41564-018-0236-1

Bibtex

@article{8abcf07b0d7b4e8398c14e5f7c702547,
title = "Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood",
abstract = "Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in ~1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth.",
keywords = "Journal Article",
author = "Stephanie Stanelle-Bertram and Kerstin Walendy-Gnir{\ss} and Thomas Speiseder and Swantje Thiele and Asante, {Ivy Asantewaa} and Carola Dreier and Kouassi, {Nancy Mounogou} and Annette Preu{\ss} and Gundula Pilnitz-Stolze and Ursula M{\"u}ller and Stefanie Thanisch and Melanie Richter and Robin Scharrenberg and Vanessa Kraus and Ronja D{\"o}rk and Lynn Schau and Vanessa Herder and Ingo Gerhauser and Pfankuche, {Vanessa Maria} and Christopher K{\"a}ufer and Inken Waltl and Thais Moraes and Julie Sellau and Stefan Hoenow and Jonas Schmidt-Chanasit and Stephanie Jansen and Benjamin Schattling and Harald Ittrich and Udo Bartsch and Thomas Renn{\'e} and Ralf Bartenschlager and Petra Arck and Daniel Cadar and Friese, {Manuel A} and Olli Vapalahti and Hanna Lotter and Sany Benites and Lane Rolling and Martin Gabriel and Wolfgang Baumg{\"a}rtner and Fabio Morellini and H{\"o}lter, {Sabine M} and Oana Amarie and Helmut Fuchs and {Hrabe de Angelis}, Martin and Wolfgang L{\"o}scher and {Calderon de Anda}, Froylan and G{\"u}lsah Gabriel",
year = "2018",
month = oct,
doi = "10.1038/s41564-018-0236-1",
language = "English",
volume = "3",
pages = "1161--1174",
journal = "NAT MICROBIOL",
issn = "2058-5276",
publisher = "NATURE PUBLISHING GROUP",
number = "10",

}

RIS

TY - JOUR

T1 - Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood

AU - Stanelle-Bertram, Stephanie

AU - Walendy-Gnirß, Kerstin

AU - Speiseder, Thomas

AU - Thiele, Swantje

AU - Asante, Ivy Asantewaa

AU - Dreier, Carola

AU - Kouassi, Nancy Mounogou

AU - Preuß, Annette

AU - Pilnitz-Stolze, Gundula

AU - Müller, Ursula

AU - Thanisch, Stefanie

AU - Richter, Melanie

AU - Scharrenberg, Robin

AU - Kraus, Vanessa

AU - Dörk, Ronja

AU - Schau, Lynn

AU - Herder, Vanessa

AU - Gerhauser, Ingo

AU - Pfankuche, Vanessa Maria

AU - Käufer, Christopher

AU - Waltl, Inken

AU - Moraes, Thais

AU - Sellau, Julie

AU - Hoenow, Stefan

AU - Schmidt-Chanasit, Jonas

AU - Jansen, Stephanie

AU - Schattling, Benjamin

AU - Ittrich, Harald

AU - Bartsch, Udo

AU - Renné, Thomas

AU - Bartenschlager, Ralf

AU - Arck, Petra

AU - Cadar, Daniel

AU - Friese, Manuel A

AU - Vapalahti, Olli

AU - Lotter, Hanna

AU - Benites, Sany

AU - Rolling, Lane

AU - Gabriel, Martin

AU - Baumgärtner, Wolfgang

AU - Morellini, Fabio

AU - Hölter, Sabine M

AU - Amarie, Oana

AU - Fuchs, Helmut

AU - Hrabe de Angelis, Martin

AU - Löscher, Wolfgang

AU - Calderon de Anda, Froylan

AU - Gabriel, Gülsah

PY - 2018/10

Y1 - 2018/10

N2 - Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in ~1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth.

AB - Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in ~1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth.

KW - Journal Article

U2 - 10.1038/s41564-018-0236-1

DO - 10.1038/s41564-018-0236-1

M3 - SCORING: Journal article

C2 - 30202017

VL - 3

SP - 1161

EP - 1174

JO - NAT MICROBIOL

JF - NAT MICROBIOL

SN - 2058-5276

IS - 10

ER -