Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
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Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood. / Stanelle-Bertram, Stephanie; Walendy-Gnirß, Kerstin; Speiseder, Thomas; Thiele, Swantje; Asante, Ivy Asantewaa; Dreier, Carola; Kouassi, Nancy Mounogou; Preuß, Annette; Pilnitz-Stolze, Gundula; Müller, Ursula; Thanisch, Stefanie; Richter, Melanie; Scharrenberg, Robin; Kraus, Vanessa; Dörk, Ronja; Schau, Lynn; Herder, Vanessa; Gerhauser, Ingo; Pfankuche, Vanessa Maria; Käufer, Christopher; Waltl, Inken; Moraes, Thais; Sellau, Julie; Hoenow, Stefan; Schmidt-Chanasit, Jonas; Jansen, Stephanie; Schattling, Benjamin; Ittrich, Harald; Bartsch, Udo; Renné, Thomas; Bartenschlager, Ralf; Arck, Petra; Cadar, Daniel; Friese, Manuel A; Vapalahti, Olli; Lotter, Hanna; Benites, Sany; Rolling, Lane; Gabriel, Martin; Baumgärtner, Wolfgang; Morellini, Fabio; Hölter, Sabine M; Amarie, Oana; Fuchs, Helmut; Hrabe de Angelis, Martin; Löscher, Wolfgang; Calderon de Anda, Froylan; Gabriel, Gülsah.
in: NAT MICROBIOL, Jahrgang 3, Nr. 10, 10.2018, S. 1161-1174.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Male offspring born to mildly ZIKV-infected mice are at risk of developing neurocognitive disorders in adulthood
AU - Stanelle-Bertram, Stephanie
AU - Walendy-Gnirß, Kerstin
AU - Speiseder, Thomas
AU - Thiele, Swantje
AU - Asante, Ivy Asantewaa
AU - Dreier, Carola
AU - Kouassi, Nancy Mounogou
AU - Preuß, Annette
AU - Pilnitz-Stolze, Gundula
AU - Müller, Ursula
AU - Thanisch, Stefanie
AU - Richter, Melanie
AU - Scharrenberg, Robin
AU - Kraus, Vanessa
AU - Dörk, Ronja
AU - Schau, Lynn
AU - Herder, Vanessa
AU - Gerhauser, Ingo
AU - Pfankuche, Vanessa Maria
AU - Käufer, Christopher
AU - Waltl, Inken
AU - Moraes, Thais
AU - Sellau, Julie
AU - Hoenow, Stefan
AU - Schmidt-Chanasit, Jonas
AU - Jansen, Stephanie
AU - Schattling, Benjamin
AU - Ittrich, Harald
AU - Bartsch, Udo
AU - Renné, Thomas
AU - Bartenschlager, Ralf
AU - Arck, Petra
AU - Cadar, Daniel
AU - Friese, Manuel A
AU - Vapalahti, Olli
AU - Lotter, Hanna
AU - Benites, Sany
AU - Rolling, Lane
AU - Gabriel, Martin
AU - Baumgärtner, Wolfgang
AU - Morellini, Fabio
AU - Hölter, Sabine M
AU - Amarie, Oana
AU - Fuchs, Helmut
AU - Hrabe de Angelis, Martin
AU - Löscher, Wolfgang
AU - Calderon de Anda, Froylan
AU - Gabriel, Gülsah
PY - 2018/10
Y1 - 2018/10
N2 - Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in ~1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth.
AB - Congenital Zika virus (ZIKV) syndrome may cause fetal microcephaly in ~1% of affected newborns. Here, we investigate whether the majority of clinically inapparent newborns might suffer from long-term health impairments not readily visible at birth. Infection of immunocompetent pregnant mice with high-dose ZIKV caused severe offspring phenotypes, such as fetal death, as expected. By contrast, low-dose (LD) maternal ZIKV infection resulted in reduced fetal birth weight but no other obvious phenotypes. Male offspring born to LD ZIKV-infected mothers had increased testosterone (TST) levels and were less likely to survive in utero infection compared to their female littermates. Males also presented an increased number of immature neurons in apical and basal hippocampal dendrites, while female offspring had immature neurons in basal dendrites only. Moreover, male offspring with high but not very high (storm) TST levels were more likely to suffer from learning and memory impairments compared to females. Future studies are required to understand the impact of TST on neuropathological and neurocognitive impairments in later life. In summary, increased sex-specific vigilance is required in countries with high ZIKV prevalence, where impaired neurodevelopment may be camouflaged by a healthy appearance at birth.
KW - Journal Article
U2 - 10.1038/s41564-018-0236-1
DO - 10.1038/s41564-018-0236-1
M3 - SCORING: Journal article
C2 - 30202017
VL - 3
SP - 1161
EP - 1174
JO - NAT MICROBIOL
JF - NAT MICROBIOL
SN - 2058-5276
IS - 10
ER -