Research ExplorerPublicationsMagnetic resonance imaging of metastases in xenograft mouse ...

Magnetic resonance imaging of metastases in xenograft mouse models of cancer

Standard

Magnetic resonance imaging of metastases in xenograft mouse models of cancer. / Peldschus, Kersten; Ittrich, Harald.

In: Methods Mol Biol, Vol. 1070, 01.01.2014, p. 213-22.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Peldschus, K & Ittrich, H 2014, 'Magnetic resonance imaging of metastases in xenograft mouse models of cancer', Methods Mol Biol, vol. 1070, pp. 213-22. https://doi.org/10.1007/978-1-4614-8244-4_16

APA

Peldschus, K., & Ittrich, H. (2014). Magnetic resonance imaging of metastases in xenograft mouse models of cancer. Methods Mol Biol, 1070, 213-22. https://doi.org/10.1007/978-1-4614-8244-4_16

Vancouver

Peldschus K, Ittrich H. Magnetic resonance imaging of metastases in xenograft mouse models of cancer. Methods Mol Biol. 2014 Jan 1;1070:213-22. https://doi.org/10.1007/978-1-4614-8244-4_16

Bibtex

@article{73c57644ebd8431dbdfa2f92740727e9,
title = "Magnetic resonance imaging of metastases in xenograft mouse models of cancer",
abstract = "Magnetic resonance imaging (MRI) of small animals has emerged as a valuable tool to noninvasively monitor tumor growth in mouse models of cancer. However, imaging of metastases in mouse models is difficult due to the need for high spatial resolution. We have demonstrated MRI of metastases in the liver, brain, adrenal glands, and lymph nodes in different xenograft mouse models of cancer. MRI of mice was performed with a clinical 3.0 T magnetic resonance scanner and a commercially available small-animal receiver coil. The imaging protocol consisted of T1- and T2-weighted fat-saturated spin echo sequences with a spatial resolution of 200 μm × 200 μm × 500 μm. Total acquisition time was 30 min per mouse. The technique allowed for repetitive examinations of larger animal cohorts to observe the development of metastases.",
keywords = "Anesthesia, Animals, Cell Line, Tumor, Contrast Media, Disease Models, Animal, Humans, Liver Neoplasms, Lymphatic Metastasis, Magnetic Resonance Imaging, Mice, Neoplasm Metastasis, Xenograft Model Antitumor Assays",
author = "Kersten Peldschus and Harald Ittrich",
year = "2014",
month = jan,
day = "1",
doi = "10.1007/978-1-4614-8244-4_16",
language = "English",
volume = "1070",
pages = "213--22",
journal = "Methods Mol Biol",
issn = "1064-3745",
publisher = "Humana Press",

}

RIS

TY - JOUR

T1 - Magnetic resonance imaging of metastases in xenograft mouse models of cancer

AU - Peldschus, Kersten

AU - Ittrich, Harald

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Magnetic resonance imaging (MRI) of small animals has emerged as a valuable tool to noninvasively monitor tumor growth in mouse models of cancer. However, imaging of metastases in mouse models is difficult due to the need for high spatial resolution. We have demonstrated MRI of metastases in the liver, brain, adrenal glands, and lymph nodes in different xenograft mouse models of cancer. MRI of mice was performed with a clinical 3.0 T magnetic resonance scanner and a commercially available small-animal receiver coil. The imaging protocol consisted of T1- and T2-weighted fat-saturated spin echo sequences with a spatial resolution of 200 μm × 200 μm × 500 μm. Total acquisition time was 30 min per mouse. The technique allowed for repetitive examinations of larger animal cohorts to observe the development of metastases.

AB - Magnetic resonance imaging (MRI) of small animals has emerged as a valuable tool to noninvasively monitor tumor growth in mouse models of cancer. However, imaging of metastases in mouse models is difficult due to the need for high spatial resolution. We have demonstrated MRI of metastases in the liver, brain, adrenal glands, and lymph nodes in different xenograft mouse models of cancer. MRI of mice was performed with a clinical 3.0 T magnetic resonance scanner and a commercially available small-animal receiver coil. The imaging protocol consisted of T1- and T2-weighted fat-saturated spin echo sequences with a spatial resolution of 200 μm × 200 μm × 500 μm. Total acquisition time was 30 min per mouse. The technique allowed for repetitive examinations of larger animal cohorts to observe the development of metastases.

KW - Anesthesia

KW - Animals

KW - Cell Line, Tumor

KW - Contrast Media

KW - Disease Models, Animal

KW - Humans

KW - Liver Neoplasms

KW - Lymphatic Metastasis

KW - Magnetic Resonance Imaging

KW - Mice

KW - Neoplasm Metastasis

KW - Xenograft Model Antitumor Assays

U2 - 10.1007/978-1-4614-8244-4_16

DO - 10.1007/978-1-4614-8244-4_16

M3 - SCORING: Journal article

C2 - 24092443

VL - 1070

SP - 213

EP - 222

JO - Methods Mol Biol

JF - Methods Mol Biol

SN - 1064-3745

ER -