Magnetic resonance imaging of metastases in xenograft mouse models of cancer
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Magnetic resonance imaging of metastases in xenograft mouse models of cancer. / Peldschus, Kersten; Ittrich, Harald.
in: Methods Mol Biol, Jahrgang 1070, 01.01.2014, S. 213-22.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Magnetic resonance imaging of metastases in xenograft mouse models of cancer
AU - Peldschus, Kersten
AU - Ittrich, Harald
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Magnetic resonance imaging (MRI) of small animals has emerged as a valuable tool to noninvasively monitor tumor growth in mouse models of cancer. However, imaging of metastases in mouse models is difficult due to the need for high spatial resolution. We have demonstrated MRI of metastases in the liver, brain, adrenal glands, and lymph nodes in different xenograft mouse models of cancer. MRI of mice was performed with a clinical 3.0 T magnetic resonance scanner and a commercially available small-animal receiver coil. The imaging protocol consisted of T1- and T2-weighted fat-saturated spin echo sequences with a spatial resolution of 200 μm × 200 μm × 500 μm. Total acquisition time was 30 min per mouse. The technique allowed for repetitive examinations of larger animal cohorts to observe the development of metastases.
AB - Magnetic resonance imaging (MRI) of small animals has emerged as a valuable tool to noninvasively monitor tumor growth in mouse models of cancer. However, imaging of metastases in mouse models is difficult due to the need for high spatial resolution. We have demonstrated MRI of metastases in the liver, brain, adrenal glands, and lymph nodes in different xenograft mouse models of cancer. MRI of mice was performed with a clinical 3.0 T magnetic resonance scanner and a commercially available small-animal receiver coil. The imaging protocol consisted of T1- and T2-weighted fat-saturated spin echo sequences with a spatial resolution of 200 μm × 200 μm × 500 μm. Total acquisition time was 30 min per mouse. The technique allowed for repetitive examinations of larger animal cohorts to observe the development of metastases.
KW - Anesthesia
KW - Animals
KW - Cell Line, Tumor
KW - Contrast Media
KW - Disease Models, Animal
KW - Humans
KW - Liver Neoplasms
KW - Lymphatic Metastasis
KW - Magnetic Resonance Imaging
KW - Mice
KW - Neoplasm Metastasis
KW - Xenograft Model Antitumor Assays
U2 - 10.1007/978-1-4614-8244-4_16
DO - 10.1007/978-1-4614-8244-4_16
M3 - SCORING: Journal article
C2 - 24092443
VL - 1070
SP - 213
EP - 222
JO - Methods Mol Biol
JF - Methods Mol Biol
SN - 1064-3745
ER -