Lymphatic Mechanoregulation in Development and Disease
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Lymphatic Mechanoregulation in Development and Disease. / Hemkemeyer, Sandra; Carlantoni, Claudia; Frye, Maike.
Biology of Extracellular Matrix: Matrix Pathobiology and Angiogenesis . ed. / Evangelia Papadimitriou; Constantinos M. Mikelis. 1. ed. Cham : Springer Nature, 2022. p. 277-311 (Biology of Extracellular Matrix).Research output: SCORING: Contribution to book/anthology › SCORING: Contribution to collected editions/anthologies › Research › peer-review
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TY - CHAP
T1 - Lymphatic Mechanoregulation in Development and Disease
AU - Hemkemeyer, Sandra
AU - Carlantoni, Claudia
AU - Frye, Maike
PY - 2022/12/19
Y1 - 2022/12/19
N2 - Endothelial cells form the innermost layer of lymphatic and blood vessels and continuously interact with their luminal and tissue microenvironment. These interactions confer extracellular mechanical information, such as fluid shear stress, cellular stretch, and matrix stiffness, on the endothelium and are subsequently translated into intracellular biological responses. The impact of changes in fluid shear stress has been extensively studied in both lymphatic and blood endothelial cells. Recent studies suggest that the tissue microenvironment, which is established by the extracellular matrix, endothelial-associated mural cells, and the surrounding tissue, also fundamentally controls vascular development and disease.In contrast to blood vessels, molecular mechanisms of lymphatic mechanoregulation via the tissue microenvironment are poorly understood. This review briefly compares what is known about the lymphatic and blood endothelial tissue microenvironment. We will further discuss how changes of the tissue microenvironment regulate lymphatic development and could contribute to dysregulation of lymphatic endothelial cells in disease. We aim to point out that a comprehensive analysis of tissue-regulated mechanisms could improve our understanding of lymphatic development and homeostasis and may eventually lead to the discovery of novel therapeutic approaches for lymphatic diseases associated with changes of the lymphatic-proximal microenvironment.
AB - Endothelial cells form the innermost layer of lymphatic and blood vessels and continuously interact with their luminal and tissue microenvironment. These interactions confer extracellular mechanical information, such as fluid shear stress, cellular stretch, and matrix stiffness, on the endothelium and are subsequently translated into intracellular biological responses. The impact of changes in fluid shear stress has been extensively studied in both lymphatic and blood endothelial cells. Recent studies suggest that the tissue microenvironment, which is established by the extracellular matrix, endothelial-associated mural cells, and the surrounding tissue, also fundamentally controls vascular development and disease.In contrast to blood vessels, molecular mechanisms of lymphatic mechanoregulation via the tissue microenvironment are poorly understood. This review briefly compares what is known about the lymphatic and blood endothelial tissue microenvironment. We will further discuss how changes of the tissue microenvironment regulate lymphatic development and could contribute to dysregulation of lymphatic endothelial cells in disease. We aim to point out that a comprehensive analysis of tissue-regulated mechanisms could improve our understanding of lymphatic development and homeostasis and may eventually lead to the discovery of novel therapeutic approaches for lymphatic diseases associated with changes of the lymphatic-proximal microenvironment.
U2 - 10.1007/978-3-031-19616-4_11
DO - 10.1007/978-3-031-19616-4_11
M3 - SCORING: Contribution to collected editions/anthologies
SN - 978-3-031-19615-7
T3 - Biology of Extracellular Matrix
SP - 277
EP - 311
BT - Biology of Extracellular Matrix
A2 - Papadimitriou, Evangelia
A2 - Mikelis, Constantinos M.
PB - Springer Nature
CY - Cham
ER -