Lymphatic Mechanoregulation in Development and Disease
Related Research units
Abstract
In contrast to blood vessels, molecular mechanisms of lymphatic mechanoregulation via the tissue microenvironment are poorly understood. This review briefly compares what is known about the lymphatic and blood endothelial tissue microenvironment. We will further discuss how changes of the tissue microenvironment regulate lymphatic development and could contribute to dysregulation of lymphatic endothelial cells in disease. We aim to point out that a comprehensive analysis of tissue-regulated mechanisms could improve our understanding of lymphatic development and homeostasis and may eventually lead to the discovery of novel therapeutic approaches for lymphatic diseases associated with changes of the lymphatic-proximal microenvironment.
Bibliographical data
Original language | English |
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Title of host publication | Biology of Extracellular Matrix : Matrix Pathobiology and Angiogenesis |
Editors | Evangelia Papadimitriou, Constantinos M. Mikelis |
REQUIRED books only: Number of pages | 35 |
Place of Publication | Cham |
Publisher | Springer Nature |
Publication date | 19.12.2022 |
Edition | 1 |
Pages | 277-311 |
ISBN (Print) | 978-3-031-19615-7 |
ISBN (Electronic) | 978-3-031-19616-4 |
DOIs | |
Publication status | Published - 19.12.2022 |