Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure
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Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure. / Glasner, Corinna; van Timmeren, Mirjan M; Stobernack, Tim; Omansen, Till F.; Raangs, Erwin C; Rossen, John W; de Goffau, Marcus C; Arends, Jan P; Kampinga, Greetje A; Koedijk, Denny G A M; Neef, Jolanda; Buist, Girbe; Tavakol, Mehri; van Wamel, Willem J B; Rutgers, Abraham; Stegeman, Coen A; Kallenberg, Cees G M; Heeringa, Peter; van Dijl, Jan Maarten.
In: SCI REP-UK, Vol. 5, 02.02.2015, p. 8188.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure
AU - Glasner, Corinna
AU - van Timmeren, Mirjan M
AU - Stobernack, Tim
AU - Omansen, Till F.
AU - Raangs, Erwin C
AU - Rossen, John W
AU - de Goffau, Marcus C
AU - Arends, Jan P
AU - Kampinga, Greetje A
AU - Koedijk, Denny G A M
AU - Neef, Jolanda
AU - Buist, Girbe
AU - Tavakol, Mehri
AU - van Wamel, Willem J B
AU - Rutgers, Abraham
AU - Stegeman, Coen A
AU - Kallenberg, Cees G M
AU - Heeringa, Peter
AU - van Dijl, Jan Maarten
PY - 2015/2/2
Y1 - 2015/2/2
N2 - Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.
AB - Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.
KW - Adult
KW - Aged
KW - Anti-Bacterial Agents/pharmacology
KW - Antibodies, Bacterial/blood
KW - Cohort Studies
KW - Drug Resistance, Bacterial
KW - Female
KW - Granulomatosis with Polyangiitis/metabolism
KW - Humans
KW - Immunoglobulin G/blood
KW - Male
KW - Microbial Sensitivity Tests
KW - Middle Aged
KW - Retrospective Studies
KW - Staphylococcus aureus/drug effects
U2 - 10.1038/srep08188
DO - 10.1038/srep08188
M3 - SCORING: Journal article
C2 - 25641235
VL - 5
SP - 8188
JO - SCI REP-UK
JF - SCI REP-UK
SN - 2045-2322
ER -