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Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure

Standard

Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure. / Glasner, Corinna; van Timmeren, Mirjan M; Stobernack, Tim; Omansen, Till F.; Raangs, Erwin C; Rossen, John W; de Goffau, Marcus C; Arends, Jan P; Kampinga, Greetje A; Koedijk, Denny G A M; Neef, Jolanda; Buist, Girbe; Tavakol, Mehri; van Wamel, Willem J B; Rutgers, Abraham; Stegeman, Coen A; Kallenberg, Cees G M; Heeringa, Peter; van Dijl, Jan Maarten.

in: SCI REP-UK, Jahrgang 5, 02.02.2015, S. 8188.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Glasner, C, van Timmeren, MM, Stobernack, T, Omansen, TF, Raangs, EC, Rossen, JW, de Goffau, MC, Arends, JP, Kampinga, GA, Koedijk, DGAM, Neef, J, Buist, G, Tavakol, M, van Wamel, WJB, Rutgers, A, Stegeman, CA, Kallenberg, CGM, Heeringa, P & van Dijl, JM 2015, 'Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure', SCI REP-UK, Jg. 5, S. 8188. https://doi.org/10.1038/srep08188

APA

Glasner, C., van Timmeren, M. M., Stobernack, T., Omansen, T. F., Raangs, E. C., Rossen, J. W., de Goffau, M. C., Arends, J. P., Kampinga, G. A., Koedijk, D. G. A. M., Neef, J., Buist, G., Tavakol, M., van Wamel, W. J. B., Rutgers, A., Stegeman, C. A., Kallenberg, C. G. M., Heeringa, P., & van Dijl, J. M. (2015). Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure. SCI REP-UK, 5, 8188. https://doi.org/10.1038/srep08188

Vancouver

Glasner C, van Timmeren MM, Stobernack T, Omansen TF, Raangs EC, Rossen JW et al. Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure. SCI REP-UK. 2015 Feb 2;5:8188. https://doi.org/10.1038/srep08188

Bibtex

@article{d73d9df5e02f4835ae8fe915a470d570,
title = "Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure",
abstract = "Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals. ",
keywords = "Adult, Aged, Anti-Bacterial Agents/pharmacology, Antibodies, Bacterial/blood, Cohort Studies, Drug Resistance, Bacterial, Female, Granulomatosis with Polyangiitis/metabolism, Humans, Immunoglobulin G/blood, Male, Microbial Sensitivity Tests, Middle Aged, Retrospective Studies, Staphylococcus aureus/drug effects",
author = "Corinna Glasner and {van Timmeren}, {Mirjan M} and Tim Stobernack and Omansen, {Till F.} and Raangs, {Erwin C} and Rossen, {John W} and {de Goffau}, {Marcus C} and Arends, {Jan P} and Kampinga, {Greetje A} and Koedijk, {Denny G A M} and Jolanda Neef and Girbe Buist and Mehri Tavakol and {van Wamel}, {Willem J B} and Abraham Rutgers and Stegeman, {Coen A} and Kallenberg, {Cees G M} and Peter Heeringa and {van Dijl}, {Jan Maarten}",
year = "2015",
month = feb,
day = "2",
doi = "10.1038/srep08188",
language = "English",
volume = "5",
pages = "8188",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure

AU - Glasner, Corinna

AU - van Timmeren, Mirjan M

AU - Stobernack, Tim

AU - Omansen, Till F.

AU - Raangs, Erwin C

AU - Rossen, John W

AU - de Goffau, Marcus C

AU - Arends, Jan P

AU - Kampinga, Greetje A

AU - Koedijk, Denny G A M

AU - Neef, Jolanda

AU - Buist, Girbe

AU - Tavakol, Mehri

AU - van Wamel, Willem J B

AU - Rutgers, Abraham

AU - Stegeman, Coen A

AU - Kallenberg, Cees G M

AU - Heeringa, Peter

AU - van Dijl, Jan Maarten

PY - 2015/2/2

Y1 - 2015/2/2

N2 - Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.

AB - Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. To date, it was neither known whether GPA patients show similar humoral immune responses to S. aureus as healthy carriers, nor whether specific S. aureus types are associated with GPA. Therefore, this study was aimed at assessing humoral immune responses of GPA patients against S. aureus antigens in relation to the genetic diversity of their nasal S. aureus isolates. A retrospective cohort study was conducted, including 85 GPA patients and 18 healthy controls (HC). Humoral immune responses against S. aureus were investigated by determining serum IgG levels against 59 S. aureus antigens. Unexpectedly, patient sera contained lower anti-staphylococcal IgG levels than sera from HC, regardless of the patients' treatment, while total IgG levels were similar or higher. Furthermore, 210 S. aureus isolates obtained from GPA patients were characterized by different typing approaches. This showed that the S. aureus population of GPA patients is highly diverse and mirrors the general S. aureus population. Our combined findings imply that GPA patients are less capable of mounting a potentially protective antibody response to S. aureus than healthy individuals.

KW - Adult

KW - Aged

KW - Anti-Bacterial Agents/pharmacology

KW - Antibodies, Bacterial/blood

KW - Cohort Studies

KW - Drug Resistance, Bacterial

KW - Female

KW - Granulomatosis with Polyangiitis/metabolism

KW - Humans

KW - Immunoglobulin G/blood

KW - Male

KW - Microbial Sensitivity Tests

KW - Middle Aged

KW - Retrospective Studies

KW - Staphylococcus aureus/drug effects

U2 - 10.1038/srep08188

DO - 10.1038/srep08188

M3 - SCORING: Journal article

C2 - 25641235

VL - 5

SP - 8188

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

ER -