Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study. / Zheng, Danni; Arima, Hisatomi; Sato, Shoichiro; Gasparrini, Antonio; Heeley, Emma; Delcourt, Candice; Lo, Serigne; Huang, Yining; Wang, Jiguang; Stapf, Christian; Robinson, Thompson; Lavados, Pablo; Chalmers, John; Anderson, Craig S; INTERACT2 investigators.
In: PLOS ONE, Vol. 11, No. 2, 2016, p. e0149040.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
AU - Zheng, Danni
AU - Arima, Hisatomi
AU - Sato, Shoichiro
AU - Gasparrini, Antonio
AU - Heeley, Emma
AU - Delcourt, Candice
AU - Lo, Serigne
AU - Huang, Yining
AU - Wang, Jiguang
AU - Stapf, Christian
AU - Robinson, Thompson
AU - Lavados, Pablo
AU - Chalmers, John
AU - Anderson, Craig S
AU - INTERACT2 investigators
AU - Thomalla, Götz
PY - 2016
Y1 - 2016
N2 - BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH.TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079.
AB - BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH.TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079.
KW - Aged
KW - Blood Pressure
KW - Cerebral Hemorrhage
KW - Cold Temperature
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Journal Article
KW - Multicenter Study
KW - Randomized Controlled Trial
KW - Research Support, Non-U.S. Gov't
U2 - 10.1371/journal.pone.0149040
DO - 10.1371/journal.pone.0149040
M3 - SCORING: Journal article
C2 - 26859491
VL - 11
SP - e0149040
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 2
ER -