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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study

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Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study. / Zheng, Danni; Arima, Hisatomi; Sato, Shoichiro; Gasparrini, Antonio; Heeley, Emma; Delcourt, Candice; Lo, Serigne; Huang, Yining; Wang, Jiguang; Stapf, Christian; Robinson, Thompson; Lavados, Pablo; Chalmers, John; Anderson, Craig S; INTERACT2 investigators.

in: PLOS ONE, Jahrgang 11, Nr. 2, 2016, S. e0149040.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zheng, D, Arima, H, Sato, S, Gasparrini, A, Heeley, E, Delcourt, C, Lo, S, Huang, Y, Wang, J, Stapf, C, Robinson, T, Lavados, P, Chalmers, J, Anderson, CS & INTERACT2 investigators 2016, 'Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study', PLOS ONE, Jg. 11, Nr. 2, S. e0149040. https://doi.org/10.1371/journal.pone.0149040

APA

Zheng, D., Arima, H., Sato, S., Gasparrini, A., Heeley, E., Delcourt, C., Lo, S., Huang, Y., Wang, J., Stapf, C., Robinson, T., Lavados, P., Chalmers, J., Anderson, C. S., & INTERACT2 investigators (2016). Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study. PLOS ONE, 11(2), e0149040. https://doi.org/10.1371/journal.pone.0149040

Vancouver

Zheng D, Arima H, Sato S, Gasparrini A, Heeley E, Delcourt C et al. Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study. PLOS ONE. 2016;11(2):e0149040. https://doi.org/10.1371/journal.pone.0149040

Bibtex

@article{7bbd9d50e670412a996be042327d5997,
title = "Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study",
abstract = "BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH.TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079.",
keywords = "Aged, Blood Pressure, Cerebral Hemorrhage, Cold Temperature, Female, Humans, Male, Middle Aged, Risk Factors, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "Danni Zheng and Hisatomi Arima and Shoichiro Sato and Antonio Gasparrini and Emma Heeley and Candice Delcourt and Serigne Lo and Yining Huang and Jiguang Wang and Christian Stapf and Thompson Robinson and Pablo Lavados and John Chalmers and Anderson, {Craig S} and {INTERACT2 investigators} and G{\"o}tz Thomalla",
year = "2016",
doi = "10.1371/journal.pone.0149040",
language = "English",
volume = "11",
pages = "e0149040",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study

AU - Zheng, Danni

AU - Arima, Hisatomi

AU - Sato, Shoichiro

AU - Gasparrini, Antonio

AU - Heeley, Emma

AU - Delcourt, Candice

AU - Lo, Serigne

AU - Huang, Yining

AU - Wang, Jiguang

AU - Stapf, Christian

AU - Robinson, Thompson

AU - Lavados, Pablo

AU - Chalmers, John

AU - Anderson, Craig S

AU - INTERACT2 investigators

AU - Thomalla, Götz

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH.TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079.

AB - BACKGROUND: Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.METHODS: INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150-220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.RESULTS: Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99-1.91) for 10°C, 1.92 (1.31-2.81) for 0°C, 3.13 (1.89-5.19) for -10°C, and 5.76 (2.30-14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.CONCLUSIONS: Exposure to low ambient temperature within several hours increases the risk of ICH.TRIAL REGISTRATION: ClinicalTrials.gov NCT00716079.

KW - Aged

KW - Blood Pressure

KW - Cerebral Hemorrhage

KW - Cold Temperature

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1371/journal.pone.0149040

DO - 10.1371/journal.pone.0149040

M3 - SCORING: Journal article

C2 - 26859491

VL - 11

SP - e0149040

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 2

ER -