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Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery

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Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery. / Lautenbach, Anne; Stoll, Fabian; Mann, Oliver; Busch, Philipp; Huber, Tobias B; Kielstein, Heike; Bähr, Ina; Aberle, Jens.

In: OBES SURG, Vol. 31, No. 7, 07.2021, p. 2913-2920.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lautenbach, A, Stoll, F, Mann, O, Busch, P, Huber, TB, Kielstein, H, Bähr, I & Aberle, J 2021, 'Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery', OBES SURG, vol. 31, no. 7, pp. 2913-2920. https://doi.org/10.1007/s11695-021-05315-y

APA

Lautenbach, A., Stoll, F., Mann, O., Busch, P., Huber, T. B., Kielstein, H., Bähr, I., & Aberle, J. (2021). Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery. OBES SURG, 31(7), 2913-2920. https://doi.org/10.1007/s11695-021-05315-y

Vancouver

Lautenbach A, Stoll F, Mann O, Busch P, Huber TB, Kielstein H et al. Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery. OBES SURG. 2021 Jul;31(7):2913-2920. https://doi.org/10.1007/s11695-021-05315-y

Bibtex

@article{856c989125954664b633a06edc232616,
title = "Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery",
abstract = "PURPOSE: Bariatric surgery (BS) was shown to improve inflammatory markers in previous short-term follow-up studies. The aim of the present study was to assess the long-term effects of BS on chronic low-grade inflammation markers related to severe obesity. Moreover, the meaning of the type of BS procedure as well as the remission of type 2 diabetes (T2D) for inflammatory status up to 4 years after BS was analyzed.MATERIALS AND METHODS: In a retrospective cohort study including 163 patients at baseline, inflammatory and metabolic parameters were assessed at 4 time points: before surgery (baseline), 6 months after surgery (visit 1), 2 years after surgery (visit 2), and 4 years after surgery (visit 3). Univariate regression analysis was used to identify variables that were thought to determine change in inflammatory parameters.RESULTS: CRP, hs-CRP, leucocytes, and ferritin significantly declined in the mid- and long-term according to the U-shaped curve of weight loss (p<0.001). Change in body mass index (BMI) at long-time follow-up showed a significant linear effect on change in leucocytes (B=0.082; p<0.001) and change in hs-CRP (B=0.03; p<0.05). There was a strong, positive correlation between T2D and hs-CRP at visit 2 (rs=0.195; p<0.05) and visit 3 (rs=0.36; p=0.001). With regard to type of surgery and gender, there were no significant differences in inflammatory parameters.CONCLUSION: BS is able to reduce obesity-related chronic low-grade inflammation up to 4 years after surgical intervention. The improvement in metaflammation is related to the change in BMI and remission of T2D in the long-term.",
keywords = "Bariatric Surgery, Diabetes Mellitus, Type 2/surgery, Humans, Inflammation/etiology, Obesity, Morbid/surgery, Retrospective Studies, Treatment Outcome",
author = "Anne Lautenbach and Fabian Stoll and Oliver Mann and Philipp Busch and Huber, {Tobias B} and Heike Kielstein and Ina B{\"a}hr and Jens Aberle",
year = "2021",
month = jul,
doi = "10.1007/s11695-021-05315-y",
language = "English",
volume = "31",
pages = "2913--2920",
journal = "OBES SURG",
issn = "0960-8923",
publisher = "Springer New York",
number = "7",

}

RIS

TY - JOUR

T1 - Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery

AU - Lautenbach, Anne

AU - Stoll, Fabian

AU - Mann, Oliver

AU - Busch, Philipp

AU - Huber, Tobias B

AU - Kielstein, Heike

AU - Bähr, Ina

AU - Aberle, Jens

PY - 2021/7

Y1 - 2021/7

N2 - PURPOSE: Bariatric surgery (BS) was shown to improve inflammatory markers in previous short-term follow-up studies. The aim of the present study was to assess the long-term effects of BS on chronic low-grade inflammation markers related to severe obesity. Moreover, the meaning of the type of BS procedure as well as the remission of type 2 diabetes (T2D) for inflammatory status up to 4 years after BS was analyzed.MATERIALS AND METHODS: In a retrospective cohort study including 163 patients at baseline, inflammatory and metabolic parameters were assessed at 4 time points: before surgery (baseline), 6 months after surgery (visit 1), 2 years after surgery (visit 2), and 4 years after surgery (visit 3). Univariate regression analysis was used to identify variables that were thought to determine change in inflammatory parameters.RESULTS: CRP, hs-CRP, leucocytes, and ferritin significantly declined in the mid- and long-term according to the U-shaped curve of weight loss (p<0.001). Change in body mass index (BMI) at long-time follow-up showed a significant linear effect on change in leucocytes (B=0.082; p<0.001) and change in hs-CRP (B=0.03; p<0.05). There was a strong, positive correlation between T2D and hs-CRP at visit 2 (rs=0.195; p<0.05) and visit 3 (rs=0.36; p=0.001). With regard to type of surgery and gender, there were no significant differences in inflammatory parameters.CONCLUSION: BS is able to reduce obesity-related chronic low-grade inflammation up to 4 years after surgical intervention. The improvement in metaflammation is related to the change in BMI and remission of T2D in the long-term.

AB - PURPOSE: Bariatric surgery (BS) was shown to improve inflammatory markers in previous short-term follow-up studies. The aim of the present study was to assess the long-term effects of BS on chronic low-grade inflammation markers related to severe obesity. Moreover, the meaning of the type of BS procedure as well as the remission of type 2 diabetes (T2D) for inflammatory status up to 4 years after BS was analyzed.MATERIALS AND METHODS: In a retrospective cohort study including 163 patients at baseline, inflammatory and metabolic parameters were assessed at 4 time points: before surgery (baseline), 6 months after surgery (visit 1), 2 years after surgery (visit 2), and 4 years after surgery (visit 3). Univariate regression analysis was used to identify variables that were thought to determine change in inflammatory parameters.RESULTS: CRP, hs-CRP, leucocytes, and ferritin significantly declined in the mid- and long-term according to the U-shaped curve of weight loss (p<0.001). Change in body mass index (BMI) at long-time follow-up showed a significant linear effect on change in leucocytes (B=0.082; p<0.001) and change in hs-CRP (B=0.03; p<0.05). There was a strong, positive correlation between T2D and hs-CRP at visit 2 (rs=0.195; p<0.05) and visit 3 (rs=0.36; p=0.001). With regard to type of surgery and gender, there were no significant differences in inflammatory parameters.CONCLUSION: BS is able to reduce obesity-related chronic low-grade inflammation up to 4 years after surgical intervention. The improvement in metaflammation is related to the change in BMI and remission of T2D in the long-term.

KW - Bariatric Surgery

KW - Diabetes Mellitus, Type 2/surgery

KW - Humans

KW - Inflammation/etiology

KW - Obesity, Morbid/surgery

KW - Retrospective Studies

KW - Treatment Outcome

U2 - 10.1007/s11695-021-05315-y

DO - 10.1007/s11695-021-05315-y

M3 - SCORING: Journal article

C2 - 33666873

VL - 31

SP - 2913

EP - 2920

JO - OBES SURG

JF - OBES SURG

SN - 0960-8923

IS - 7

ER -