Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery
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Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery. / Lautenbach, Anne; Stoll, Fabian; Mann, Oliver; Busch, Philipp; Huber, Tobias B; Kielstein, Heike; Bähr, Ina; Aberle, Jens.
in: OBES SURG, Jahrgang 31, Nr. 7, 07.2021, S. 2913-2920.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Long-Term Improvement of Chronic Low-Grade Inflammation After Bariatric Surgery
AU - Lautenbach, Anne
AU - Stoll, Fabian
AU - Mann, Oliver
AU - Busch, Philipp
AU - Huber, Tobias B
AU - Kielstein, Heike
AU - Bähr, Ina
AU - Aberle, Jens
PY - 2021/7
Y1 - 2021/7
N2 - PURPOSE: Bariatric surgery (BS) was shown to improve inflammatory markers in previous short-term follow-up studies. The aim of the present study was to assess the long-term effects of BS on chronic low-grade inflammation markers related to severe obesity. Moreover, the meaning of the type of BS procedure as well as the remission of type 2 diabetes (T2D) for inflammatory status up to 4 years after BS was analyzed.MATERIALS AND METHODS: In a retrospective cohort study including 163 patients at baseline, inflammatory and metabolic parameters were assessed at 4 time points: before surgery (baseline), 6 months after surgery (visit 1), 2 years after surgery (visit 2), and 4 years after surgery (visit 3). Univariate regression analysis was used to identify variables that were thought to determine change in inflammatory parameters.RESULTS: CRP, hs-CRP, leucocytes, and ferritin significantly declined in the mid- and long-term according to the U-shaped curve of weight loss (p<0.001). Change in body mass index (BMI) at long-time follow-up showed a significant linear effect on change in leucocytes (B=0.082; p<0.001) and change in hs-CRP (B=0.03; p<0.05). There was a strong, positive correlation between T2D and hs-CRP at visit 2 (rs=0.195; p<0.05) and visit 3 (rs=0.36; p=0.001). With regard to type of surgery and gender, there were no significant differences in inflammatory parameters.CONCLUSION: BS is able to reduce obesity-related chronic low-grade inflammation up to 4 years after surgical intervention. The improvement in metaflammation is related to the change in BMI and remission of T2D in the long-term.
AB - PURPOSE: Bariatric surgery (BS) was shown to improve inflammatory markers in previous short-term follow-up studies. The aim of the present study was to assess the long-term effects of BS on chronic low-grade inflammation markers related to severe obesity. Moreover, the meaning of the type of BS procedure as well as the remission of type 2 diabetes (T2D) for inflammatory status up to 4 years after BS was analyzed.MATERIALS AND METHODS: In a retrospective cohort study including 163 patients at baseline, inflammatory and metabolic parameters were assessed at 4 time points: before surgery (baseline), 6 months after surgery (visit 1), 2 years after surgery (visit 2), and 4 years after surgery (visit 3). Univariate regression analysis was used to identify variables that were thought to determine change in inflammatory parameters.RESULTS: CRP, hs-CRP, leucocytes, and ferritin significantly declined in the mid- and long-term according to the U-shaped curve of weight loss (p<0.001). Change in body mass index (BMI) at long-time follow-up showed a significant linear effect on change in leucocytes (B=0.082; p<0.001) and change in hs-CRP (B=0.03; p<0.05). There was a strong, positive correlation between T2D and hs-CRP at visit 2 (rs=0.195; p<0.05) and visit 3 (rs=0.36; p=0.001). With regard to type of surgery and gender, there were no significant differences in inflammatory parameters.CONCLUSION: BS is able to reduce obesity-related chronic low-grade inflammation up to 4 years after surgical intervention. The improvement in metaflammation is related to the change in BMI and remission of T2D in the long-term.
KW - Bariatric Surgery
KW - Diabetes Mellitus, Type 2/surgery
KW - Humans
KW - Inflammation/etiology
KW - Obesity, Morbid/surgery
KW - Retrospective Studies
KW - Treatment Outcome
U2 - 10.1007/s11695-021-05315-y
DO - 10.1007/s11695-021-05315-y
M3 - SCORING: Journal article
C2 - 33666873
VL - 31
SP - 2913
EP - 2920
JO - OBES SURG
JF - OBES SURG
SN - 0960-8923
IS - 7
ER -