Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes
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Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. / Martino, R; Henseler, A; van Lint, M; Schaap, N; Finke, J; Beelen, D; Vigouroux, S; Alessandrino, E P; Mufti, G J; Veelken, J H; Bruno, B; Yakoub-Agha, I; Volin, L; Maertens, J; Or, R; Leblond, V; Rovira, M; Kalhs, P; Alvarez, A F; Vitek, A; Sierra, J; Wagner, E; Robin, M; de Witte, T; Kröger, N.
In: BONE MARROW TRANSPL, Vol. 52, No. 8, 08.2017, p. 1107-1112.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes
AU - Martino, R
AU - Henseler, A
AU - van Lint, M
AU - Schaap, N
AU - Finke, J
AU - Beelen, D
AU - Vigouroux, S
AU - Alessandrino, E P
AU - Mufti, G J
AU - Veelken, J H
AU - Bruno, B
AU - Yakoub-Agha, I
AU - Volin, L
AU - Maertens, J
AU - Or, R
AU - Leblond, V
AU - Rovira, M
AU - Kalhs, P
AU - Alvarez, A F
AU - Vitek, A
AU - Sierra, J
AU - Wagner, E
AU - Robin, M
AU - de Witte, T
AU - Kröger, N
PY - 2017/8
Y1 - 2017/8
N2 - This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P<0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.
AB - This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P<0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.
KW - Journal Article
U2 - 10.1038/bmt.2017.19
DO - 10.1038/bmt.2017.19
M3 - SCORING: Journal article
C2 - 28319072
VL - 52
SP - 1107
EP - 1112
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 8
ER -