PortalPublikationenLong-term follow-up of a retrospective comparison of reduced...

Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes

Standard

Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. / Martino, R; Henseler, A; van Lint, M; Schaap, N; Finke, J; Beelen, D; Vigouroux, S; Alessandrino, E P; Mufti, G J; Veelken, J H; Bruno, B; Yakoub-Agha, I; Volin, L; Maertens, J; Or, R; Leblond, V; Rovira, M; Kalhs, P; Alvarez, A F; Vitek, A; Sierra, J; Wagner, E; Robin, M; de Witte, T; Kröger, N.

in: BONE MARROW TRANSPL, Jahrgang 52, Nr. 8, 08.2017, S. 1107-1112.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Martino, R, Henseler, A, van Lint, M, Schaap, N, Finke, J, Beelen, D, Vigouroux, S, Alessandrino, EP, Mufti, GJ, Veelken, JH, Bruno, B, Yakoub-Agha, I, Volin, L, Maertens, J, Or, R, Leblond, V, Rovira, M, Kalhs, P, Alvarez, AF, Vitek, A, Sierra, J, Wagner, E, Robin, M, de Witte, T & Kröger, N 2017, 'Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes', BONE MARROW TRANSPL, Jg. 52, Nr. 8, S. 1107-1112. https://doi.org/10.1038/bmt.2017.19

APA

Martino, R., Henseler, A., van Lint, M., Schaap, N., Finke, J., Beelen, D., Vigouroux, S., Alessandrino, E. P., Mufti, G. J., Veelken, J. H., Bruno, B., Yakoub-Agha, I., Volin, L., Maertens, J., Or, R., Leblond, V., Rovira, M., Kalhs, P., Alvarez, A. F., ... Kröger, N. (2017). Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. BONE MARROW TRANSPL, 52(8), 1107-1112. https://doi.org/10.1038/bmt.2017.19

Vancouver

Martino R, Henseler A, van Lint M, Schaap N, Finke J, Beelen D et al. Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes. BONE MARROW TRANSPL. 2017 Aug;52(8):1107-1112. https://doi.org/10.1038/bmt.2017.19

Bibtex

@article{adda9748b2e04288a9062de5e7067cf6,
title = "Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes",
abstract = "This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P<0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.",
keywords = "Journal Article",
author = "R Martino and A Henseler and {van Lint}, M and N Schaap and J Finke and D Beelen and S Vigouroux and Alessandrino, {E P} and Mufti, {G J} and Veelken, {J H} and B Bruno and I Yakoub-Agha and L Volin and J Maertens and R Or and V Leblond and M Rovira and P Kalhs and Alvarez, {A F} and A Vitek and J Sierra and E Wagner and M Robin and {de Witte}, T and N Kr{\"o}ger",
year = "2017",
month = aug,
doi = "10.1038/bmt.2017.19",
language = "English",
volume = "52",
pages = "1107--1112",
journal = "BONE MARROW TRANSPL",
issn = "0268-3369",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Long-term follow-up of a retrospective comparison of reduced-intensity conditioning and conventional high-dose conditioning for allogeneic transplantation from matched related donors in myelodysplastic syndromes

AU - Martino, R

AU - Henseler, A

AU - van Lint, M

AU - Schaap, N

AU - Finke, J

AU - Beelen, D

AU - Vigouroux, S

AU - Alessandrino, E P

AU - Mufti, G J

AU - Veelken, J H

AU - Bruno, B

AU - Yakoub-Agha, I

AU - Volin, L

AU - Maertens, J

AU - Or, R

AU - Leblond, V

AU - Rovira, M

AU - Kalhs, P

AU - Alvarez, A F

AU - Vitek, A

AU - Sierra, J

AU - Wagner, E

AU - Robin, M

AU - de Witte, T

AU - Kröger, N

PY - 2017/8

Y1 - 2017/8

N2 - This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P<0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.

AB - This study shows the long-term updated outcomes of a multicenter retrospective study which analyzed 843 patients with myelodysplastic syndrome (MDS) who underwent transplantation with an HLA-identical sibling donor with either reduced-intensity conditioning (RIC) in 213 patients, or standard myeloablative conditioning (MAC) in 630 patients. In multivariate analysis, the 13-year relapse rate was significantly increased after RIC (31% after MAC vs 48% in RIC; HR, 1.5; 95% CI, 1.1-1.9; P=0.04), but with no differences in overall survival (OS) (30% after MAC vs 27% in RIC; P=0.4) and PFS (29 vs 21%, respectively, P=0.3). Non-relapse mortality was higher in MAC (40 vs 31%; P=0.1), especially in patients older than 50 years (50 vs 33%, P<0.01). In addition, long-term follow-up confirms the importance of other variables on 13-year OS, mainly MDS risk category, disease phase, cytogenetics and receiving a high donor cell dose, irrespective of the conditioning regimen used.

KW - Journal Article

U2 - 10.1038/bmt.2017.19

DO - 10.1038/bmt.2017.19

M3 - SCORING: Journal article

C2 - 28319072

VL - 52

SP - 1107

EP - 1112

JO - BONE MARROW TRANSPL

JF - BONE MARROW TRANSPL

SN - 0268-3369

IS - 8

ER -