Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial
Standard
Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial. / Louis, Valérie R; Bals, Joëlle; Tiendrebéogo, Justin; Bountogo, Mamadou; Ramroth, Heribert; De Allegri, Manuela; Traoré, Corneille; Beiersmann, Claudia; Coulibaly, Boubacar; Yé, Maurice; Jahn, Albrecht; Becher, Heiko; Müller, Olaf.
In: TROP MED INT HEALTH, Vol. 17, No. 6, 01.06.2012, p. 733-41.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial
AU - Louis, Valérie R
AU - Bals, Joëlle
AU - Tiendrebéogo, Justin
AU - Bountogo, Mamadou
AU - Ramroth, Heribert
AU - De Allegri, Manuela
AU - Traoré, Corneille
AU - Beiersmann, Claudia
AU - Coulibaly, Boubacar
AU - Yé, Maurice
AU - Jahn, Albrecht
AU - Becher, Heiko
AU - Müller, Olaf
N1 - © 2012 Blackwell Publishing Ltd.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - OBJECTIVE: The objective is to investigate the effect of malaria control with insecticide-treated mosquito nets (ITNs) regarding possible higher mortality in children protected during early infancy, due to interference with immunity development, and to assess long-term effects on malaria prevalence and morbidity.METHODS: Between 2000 and 2002, a birth cohort was enrolled in 41 villages of a malaria holoendemic area in north-western Burkina Faso. All neonates (n = 3387) were individually randomised to ITN protection from birth (group A) vs. ITN protection from age 6 months (group B). Primary outcome was all-cause mortality. In 2009, a survey took place in six sentinel villages, and in 2010, a census was conducted in all study villages.RESULTS: After a median follow-up time of 8.3 years, 443/3387 (13.1%) children had migrated out of the area and 484/2944 (16.4%) had died, mostly at home. Long-term compliance with ITN protection was good. There were no differences in mortality between study groups (248 deaths in group A, 236 deaths in group B; rate ratio 1.05, 95% CI: 0.889-1.237, P = 0.574). The survey conducted briefly after the rainy season in 2009 showed that more than 80% of study children carried asexual malaria parasites and up to 20% had clinical malaria.CONCLUSION: Insecticide-treated mosquito net protection in early infancy is not a risk factor for mortality. Individual ITN protection does not sufficiently reduce malaria prevalence in high-transmission areas. Achieving universal ITN coverage remains a major challenge for malaria prevention in Africa.
AB - OBJECTIVE: The objective is to investigate the effect of malaria control with insecticide-treated mosquito nets (ITNs) regarding possible higher mortality in children protected during early infancy, due to interference with immunity development, and to assess long-term effects on malaria prevalence and morbidity.METHODS: Between 2000 and 2002, a birth cohort was enrolled in 41 villages of a malaria holoendemic area in north-western Burkina Faso. All neonates (n = 3387) were individually randomised to ITN protection from birth (group A) vs. ITN protection from age 6 months (group B). Primary outcome was all-cause mortality. In 2009, a survey took place in six sentinel villages, and in 2010, a census was conducted in all study villages.RESULTS: After a median follow-up time of 8.3 years, 443/3387 (13.1%) children had migrated out of the area and 484/2944 (16.4%) had died, mostly at home. Long-term compliance with ITN protection was good. There were no differences in mortality between study groups (248 deaths in group A, 236 deaths in group B; rate ratio 1.05, 95% CI: 0.889-1.237, P = 0.574). The survey conducted briefly after the rainy season in 2009 showed that more than 80% of study children carried asexual malaria parasites and up to 20% had clinical malaria.CONCLUSION: Insecticide-treated mosquito net protection in early infancy is not a risk factor for mortality. Individual ITN protection does not sufficiently reduce malaria prevalence in high-transmission areas. Achieving universal ITN coverage remains a major challenge for malaria prevention in Africa.
KW - Burkina Faso
KW - Child
KW - Child, Preschool
KW - Cohort Studies
KW - Female
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Insecticide-Treated Bednets
KW - Insecticides
KW - Malaria
KW - Male
KW - Mosquito Control
KW - Risk Factors
KW - Rural Population
KW - Survival Analysis
KW - Time
U2 - 10.1111/j.1365-3156.2012.02990.x
DO - 10.1111/j.1365-3156.2012.02990.x
M3 - SCORING: Journal article
C2 - 22519853
VL - 17
SP - 733
EP - 741
JO - TROP MED INT HEALTH
JF - TROP MED INT HEALTH
SN - 1360-2276
IS - 6
ER -