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Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial

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Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial. / Louis, Valérie R; Bals, Joëlle; Tiendrebéogo, Justin; Bountogo, Mamadou; Ramroth, Heribert; De Allegri, Manuela; Traoré, Corneille; Beiersmann, Claudia; Coulibaly, Boubacar; Yé, Maurice; Jahn, Albrecht; Becher, Heiko; Müller, Olaf.

in: TROP MED INT HEALTH, Jahrgang 17, Nr. 6, 01.06.2012, S. 733-41.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Louis, VR, Bals, J, Tiendrebéogo, J, Bountogo, M, Ramroth, H, De Allegri, M, Traoré, C, Beiersmann, C, Coulibaly, B, Yé, M, Jahn, A, Becher, H & Müller, O 2012, 'Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial', TROP MED INT HEALTH, Jg. 17, Nr. 6, S. 733-41. https://doi.org/10.1111/j.1365-3156.2012.02990.x

APA

Louis, V. R., Bals, J., Tiendrebéogo, J., Bountogo, M., Ramroth, H., De Allegri, M., Traoré, C., Beiersmann, C., Coulibaly, B., Yé, M., Jahn, A., Becher, H., & Müller, O. (2012). Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial. TROP MED INT HEALTH, 17(6), 733-41. https://doi.org/10.1111/j.1365-3156.2012.02990.x

Vancouver

Louis VR, Bals J, Tiendrebéogo J, Bountogo M, Ramroth H, De Allegri M et al. Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial. TROP MED INT HEALTH. 2012 Jun 1;17(6):733-41. https://doi.org/10.1111/j.1365-3156.2012.02990.x

Bibtex

@article{fa97572b9b9b4d8583aa45db9f41fc4f,
title = "Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial",
abstract = "OBJECTIVE: The objective is to investigate the effect of malaria control with insecticide-treated mosquito nets (ITNs) regarding possible higher mortality in children protected during early infancy, due to interference with immunity development, and to assess long-term effects on malaria prevalence and morbidity.METHODS: Between 2000 and 2002, a birth cohort was enrolled in 41 villages of a malaria holoendemic area in north-western Burkina Faso. All neonates (n = 3387) were individually randomised to ITN protection from birth (group A) vs. ITN protection from age 6 months (group B). Primary outcome was all-cause mortality. In 2009, a survey took place in six sentinel villages, and in 2010, a census was conducted in all study villages.RESULTS: After a median follow-up time of 8.3 years, 443/3387 (13.1%) children had migrated out of the area and 484/2944 (16.4%) had died, mostly at home. Long-term compliance with ITN protection was good. There were no differences in mortality between study groups (248 deaths in group A, 236 deaths in group B; rate ratio 1.05, 95% CI: 0.889-1.237, P = 0.574). The survey conducted briefly after the rainy season in 2009 showed that more than 80% of study children carried asexual malaria parasites and up to 20% had clinical malaria.CONCLUSION: Insecticide-treated mosquito net protection in early infancy is not a risk factor for mortality. Individual ITN protection does not sufficiently reduce malaria prevalence in high-transmission areas. Achieving universal ITN coverage remains a major challenge for malaria prevention in Africa.",
keywords = "Burkina Faso, Child, Child, Preschool, Cohort Studies, Female, Humans, Infant, Infant, Newborn, Insecticide-Treated Bednets, Insecticides, Malaria, Male, Mosquito Control, Risk Factors, Rural Population, Survival Analysis, Time",
author = "Louis, {Val{\'e}rie R} and Jo{\"e}lle Bals and Justin Tiendreb{\'e}ogo and Mamadou Bountogo and Heribert Ramroth and {De Allegri}, Manuela and Corneille Traor{\'e} and Claudia Beiersmann and Boubacar Coulibaly and Maurice Y{\'e} and Albrecht Jahn and Heiko Becher and Olaf M{\"u}ller",
note = "{\textcopyright} 2012 Blackwell Publishing Ltd.",
year = "2012",
month = jun,
day = "1",
doi = "10.1111/j.1365-3156.2012.02990.x",
language = "English",
volume = "17",
pages = "733--41",
journal = "TROP MED INT HEALTH",
issn = "1360-2276",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Long-term effects of malaria prevention with insecticide-treated mosquito nets on morbidity and mortality in African children: randomised controlled trial

AU - Louis, Valérie R

AU - Bals, Joëlle

AU - Tiendrebéogo, Justin

AU - Bountogo, Mamadou

AU - Ramroth, Heribert

AU - De Allegri, Manuela

AU - Traoré, Corneille

AU - Beiersmann, Claudia

AU - Coulibaly, Boubacar

AU - Yé, Maurice

AU - Jahn, Albrecht

AU - Becher, Heiko

AU - Müller, Olaf

N1 - © 2012 Blackwell Publishing Ltd.

PY - 2012/6/1

Y1 - 2012/6/1

N2 - OBJECTIVE: The objective is to investigate the effect of malaria control with insecticide-treated mosquito nets (ITNs) regarding possible higher mortality in children protected during early infancy, due to interference with immunity development, and to assess long-term effects on malaria prevalence and morbidity.METHODS: Between 2000 and 2002, a birth cohort was enrolled in 41 villages of a malaria holoendemic area in north-western Burkina Faso. All neonates (n = 3387) were individually randomised to ITN protection from birth (group A) vs. ITN protection from age 6 months (group B). Primary outcome was all-cause mortality. In 2009, a survey took place in six sentinel villages, and in 2010, a census was conducted in all study villages.RESULTS: After a median follow-up time of 8.3 years, 443/3387 (13.1%) children had migrated out of the area and 484/2944 (16.4%) had died, mostly at home. Long-term compliance with ITN protection was good. There were no differences in mortality between study groups (248 deaths in group A, 236 deaths in group B; rate ratio 1.05, 95% CI: 0.889-1.237, P = 0.574). The survey conducted briefly after the rainy season in 2009 showed that more than 80% of study children carried asexual malaria parasites and up to 20% had clinical malaria.CONCLUSION: Insecticide-treated mosquito net protection in early infancy is not a risk factor for mortality. Individual ITN protection does not sufficiently reduce malaria prevalence in high-transmission areas. Achieving universal ITN coverage remains a major challenge for malaria prevention in Africa.

AB - OBJECTIVE: The objective is to investigate the effect of malaria control with insecticide-treated mosquito nets (ITNs) regarding possible higher mortality in children protected during early infancy, due to interference with immunity development, and to assess long-term effects on malaria prevalence and morbidity.METHODS: Between 2000 and 2002, a birth cohort was enrolled in 41 villages of a malaria holoendemic area in north-western Burkina Faso. All neonates (n = 3387) were individually randomised to ITN protection from birth (group A) vs. ITN protection from age 6 months (group B). Primary outcome was all-cause mortality. In 2009, a survey took place in six sentinel villages, and in 2010, a census was conducted in all study villages.RESULTS: After a median follow-up time of 8.3 years, 443/3387 (13.1%) children had migrated out of the area and 484/2944 (16.4%) had died, mostly at home. Long-term compliance with ITN protection was good. There were no differences in mortality between study groups (248 deaths in group A, 236 deaths in group B; rate ratio 1.05, 95% CI: 0.889-1.237, P = 0.574). The survey conducted briefly after the rainy season in 2009 showed that more than 80% of study children carried asexual malaria parasites and up to 20% had clinical malaria.CONCLUSION: Insecticide-treated mosquito net protection in early infancy is not a risk factor for mortality. Individual ITN protection does not sufficiently reduce malaria prevalence in high-transmission areas. Achieving universal ITN coverage remains a major challenge for malaria prevention in Africa.

KW - Burkina Faso

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Female

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Insecticide-Treated Bednets

KW - Insecticides

KW - Malaria

KW - Male

KW - Mosquito Control

KW - Risk Factors

KW - Rural Population

KW - Survival Analysis

KW - Time

U2 - 10.1111/j.1365-3156.2012.02990.x

DO - 10.1111/j.1365-3156.2012.02990.x

M3 - SCORING: Journal article

C2 - 22519853

VL - 17

SP - 733

EP - 741

JO - TROP MED INT HEALTH

JF - TROP MED INT HEALTH

SN - 1360-2276

IS - 6

ER -