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Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study

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Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. / Heitmann, Henrik; Haller, Bernhard; Tiemann, Laura; Mühlau, Mark; Berthele, Achim; Tölle, Thomas R; Salmen, Anke; Ambrosius, Björn; Bayas, Antonios; Asseyer, Susanna; Hartung, Hans-Peter; Heesen, Christoph; Stangel, Martin; Wildemann, Brigitte; Haars, Sarah; Groppa, Sergiu; Luessi, Felix; Kümpfel, Tania; Nischwitz, Sandra; Meuth, Sven G; Klotz, Luisa; Linker, Ralf A; Zettl, Uwe K; Ziemann, Ulf; Tumani, Hayrettin; Tackenberg, Björn; Zipp, Frauke; Wiendl, Heinz; Gold, Ralf; Hemmer, Bernhard; Ploner, Markus; German Competence Network of Multiple Sclerosis.

In: PAIN, Vol. 161, No. 4, 04.2020, p. 787-796.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heitmann, H, Haller, B, Tiemann, L, Mühlau, M, Berthele, A, Tölle, TR, Salmen, A, Ambrosius, B, Bayas, A, Asseyer, S, Hartung, H-P, Heesen, C, Stangel, M, Wildemann, B, Haars, S, Groppa, S, Luessi, F, Kümpfel, T, Nischwitz, S, Meuth, SG, Klotz, L, Linker, RA, Zettl, UK, Ziemann, U, Tumani, H, Tackenberg, B, Zipp, F, Wiendl, H, Gold, R, Hemmer, B, Ploner, M & German Competence Network of Multiple Sclerosis 2020, 'Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study', PAIN, vol. 161, no. 4, pp. 787-796. https://doi.org/10.1097/j.pain.0000000000001767

APA

Heitmann, H., Haller, B., Tiemann, L., Mühlau, M., Berthele, A., Tölle, T. R., Salmen, A., Ambrosius, B., Bayas, A., Asseyer, S., Hartung, H-P., Heesen, C., Stangel, M., Wildemann, B., Haars, S., Groppa, S., Luessi, F., Kümpfel, T., Nischwitz, S., ... German Competence Network of Multiple Sclerosis (2020). Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. PAIN, 161(4), 787-796. https://doi.org/10.1097/j.pain.0000000000001767

Vancouver

Heitmann H, Haller B, Tiemann L, Mühlau M, Berthele A, Tölle TR et al. Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. PAIN. 2020 Apr;161(4):787-796. https://doi.org/10.1097/j.pain.0000000000001767

Bibtex

@article{d34c2a91a7bd4ec5bde8aad00f6bb31a,
title = "Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study",
abstract = "Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatric assessment included tests for fatigue, depression, and cognition. In addition, sociodemographic and clinical data were obtained. Prevalence of pain of any type was 40% and 36% at baseline and after 4 years, respectively, whereas prevalence of NP was 2% and 5%. Pain of any type and NP were both strongly linked to fatigue, depression, and disability. This link was even stronger after 4 years than at baseline. Moreover, changes in pain, depression, and fatigue were highly correlated without any of these symptoms preceding the others. Taken together, pain of any type seems to be much more frequent than NP in early nonprogressive MS. Moreover, the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology.",
author = "Henrik Heitmann and Bernhard Haller and Laura Tiemann and Mark M{\"u}hlau and Achim Berthele and T{\"o}lle, {Thomas R} and Anke Salmen and Bj{\"o}rn Ambrosius and Antonios Bayas and Susanna Asseyer and Hans-Peter Hartung and Christoph Heesen and Martin Stangel and Brigitte Wildemann and Sarah Haars and Sergiu Groppa and Felix Luessi and Tania K{\"u}mpfel and Sandra Nischwitz and Meuth, {Sven G} and Luisa Klotz and Linker, {Ralf A} and Zettl, {Uwe K} and Ulf Ziemann and Hayrettin Tumani and Bj{\"o}rn Tackenberg and Frauke Zipp and Heinz Wiendl and Ralf Gold and Bernhard Hemmer and Markus Ploner and {German Competence Network of Multiple Sclerosis}",
year = "2020",
month = apr,
doi = "10.1097/j.pain.0000000000001767",
language = "English",
volume = "161",
pages = "787--796",
journal = "PAIN",
issn = "0304-3959",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study

AU - Heitmann, Henrik

AU - Haller, Bernhard

AU - Tiemann, Laura

AU - Mühlau, Mark

AU - Berthele, Achim

AU - Tölle, Thomas R

AU - Salmen, Anke

AU - Ambrosius, Björn

AU - Bayas, Antonios

AU - Asseyer, Susanna

AU - Hartung, Hans-Peter

AU - Heesen, Christoph

AU - Stangel, Martin

AU - Wildemann, Brigitte

AU - Haars, Sarah

AU - Groppa, Sergiu

AU - Luessi, Felix

AU - Kümpfel, Tania

AU - Nischwitz, Sandra

AU - Meuth, Sven G

AU - Klotz, Luisa

AU - Linker, Ralf A

AU - Zettl, Uwe K

AU - Ziemann, Ulf

AU - Tumani, Hayrettin

AU - Tackenberg, Björn

AU - Zipp, Frauke

AU - Wiendl, Heinz

AU - Gold, Ralf

AU - Hemmer, Bernhard

AU - Ploner, Markus

AU - German Competence Network of Multiple Sclerosis

PY - 2020/4

Y1 - 2020/4

N2 - Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatric assessment included tests for fatigue, depression, and cognition. In addition, sociodemographic and clinical data were obtained. Prevalence of pain of any type was 40% and 36% at baseline and after 4 years, respectively, whereas prevalence of NP was 2% and 5%. Pain of any type and NP were both strongly linked to fatigue, depression, and disability. This link was even stronger after 4 years than at baseline. Moreover, changes in pain, depression, and fatigue were highly correlated without any of these symptoms preceding the others. Taken together, pain of any type seems to be much more frequent than NP in early nonprogressive MS. Moreover, the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology.

AB - Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatric assessment included tests for fatigue, depression, and cognition. In addition, sociodemographic and clinical data were obtained. Prevalence of pain of any type was 40% and 36% at baseline and after 4 years, respectively, whereas prevalence of NP was 2% and 5%. Pain of any type and NP were both strongly linked to fatigue, depression, and disability. This link was even stronger after 4 years than at baseline. Moreover, changes in pain, depression, and fatigue were highly correlated without any of these symptoms preceding the others. Taken together, pain of any type seems to be much more frequent than NP in early nonprogressive MS. Moreover, the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology.

U2 - 10.1097/j.pain.0000000000001767

DO - 10.1097/j.pain.0000000000001767

M3 - SCORING: Journal article

C2 - 32197038

VL - 161

SP - 787

EP - 796

JO - PAIN

JF - PAIN

SN - 0304-3959

IS - 4

ER -