Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study
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Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study. / Heitmann, Henrik; Haller, Bernhard; Tiemann, Laura; Mühlau, Mark; Berthele, Achim; Tölle, Thomas R; Salmen, Anke; Ambrosius, Björn; Bayas, Antonios; Asseyer, Susanna; Hartung, Hans-Peter; Heesen, Christoph; Stangel, Martin; Wildemann, Brigitte; Haars, Sarah; Groppa, Sergiu; Luessi, Felix; Kümpfel, Tania; Nischwitz, Sandra; Meuth, Sven G; Klotz, Luisa; Linker, Ralf A; Zettl, Uwe K; Ziemann, Ulf; Tumani, Hayrettin; Tackenberg, Björn; Zipp, Frauke; Wiendl, Heinz; Gold, Ralf; Hemmer, Bernhard; Ploner, Markus; German Competence Network of Multiple Sclerosis.
in: PAIN, Jahrgang 161, Nr. 4, 04.2020, S. 787-796.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Longitudinal prevalence and determinants of pain in multiple sclerosis: results from the German National Multiple Sclerosis Cohort study
AU - Heitmann, Henrik
AU - Haller, Bernhard
AU - Tiemann, Laura
AU - Mühlau, Mark
AU - Berthele, Achim
AU - Tölle, Thomas R
AU - Salmen, Anke
AU - Ambrosius, Björn
AU - Bayas, Antonios
AU - Asseyer, Susanna
AU - Hartung, Hans-Peter
AU - Heesen, Christoph
AU - Stangel, Martin
AU - Wildemann, Brigitte
AU - Haars, Sarah
AU - Groppa, Sergiu
AU - Luessi, Felix
AU - Kümpfel, Tania
AU - Nischwitz, Sandra
AU - Meuth, Sven G
AU - Klotz, Luisa
AU - Linker, Ralf A
AU - Zettl, Uwe K
AU - Ziemann, Ulf
AU - Tumani, Hayrettin
AU - Tackenberg, Björn
AU - Zipp, Frauke
AU - Wiendl, Heinz
AU - Gold, Ralf
AU - Hemmer, Bernhard
AU - Ploner, Markus
AU - German Competence Network of Multiple Sclerosis
PY - 2020/4
Y1 - 2020/4
N2 - Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatric assessment included tests for fatigue, depression, and cognition. In addition, sociodemographic and clinical data were obtained. Prevalence of pain of any type was 40% and 36% at baseline and after 4 years, respectively, whereas prevalence of NP was 2% and 5%. Pain of any type and NP were both strongly linked to fatigue, depression, and disability. This link was even stronger after 4 years than at baseline. Moreover, changes in pain, depression, and fatigue were highly correlated without any of these symptoms preceding the others. Taken together, pain of any type seems to be much more frequent than NP in early nonprogressive MS. Moreover, the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology.
AB - Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, and causal relationships between pain and biopsychosocial factors in MS are largely unknown. Longitudinal studies might help to clarify the prevalence and determinants of pain in MS. To this end, we analyzed data from 410 patients with newly diagnosed clinically isolated syndrome or relapsing-remitting MS participating in the prospective multicenter German National MS Cohort Study (NationMS) at baseline and after 4 years. Pain was assessed by self-report using the PainDETECT Questionnaire. Neuropsychiatric assessment included tests for fatigue, depression, and cognition. In addition, sociodemographic and clinical data were obtained. Prevalence of pain of any type was 40% and 36% at baseline and after 4 years, respectively, whereas prevalence of NP was 2% and 5%. Pain of any type and NP were both strongly linked to fatigue, depression, and disability. This link was even stronger after 4 years than at baseline. Moreover, changes in pain, depression, and fatigue were highly correlated without any of these symptoms preceding the others. Taken together, pain of any type seems to be much more frequent than NP in early nonprogressive MS. Moreover, the close relationship between pain, fatigue, and depression in MS should be considered for treatment decisions and future research on a possible common pathophysiology.
U2 - 10.1097/j.pain.0000000000001767
DO - 10.1097/j.pain.0000000000001767
M3 - SCORING: Journal article
C2 - 32197038
VL - 161
SP - 787
EP - 796
JO - PAIN
JF - PAIN
SN - 0304-3959
IS - 4
ER -