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Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction

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Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction. / Mylrea-Foley, Bronacha; Wolf, Hans; Stampalija, Tamara; Lees, Christoph; Arabin, B; Berger, A; Bergman, E; Bhide, A; Bilardo, C M; Breeze, A C; Brodszki, J; Calda, P; Cetin, I; Cesari, E; Derks, J; Ebbing, C; Ferrazzi, E; Ganzevoort, W; Frusca, T; Gordijn, S J; Gyselaers, W; Hecher, K; Klaritsch, P; Krofta, L; Lindgren, P; Lobmaier, S M; Marlow, N; Maruotti, G M; Mecacci, F; Myklestad, K; Napolitano, R; Prefumo, F; Raio, L; Richter, J; Sande, R K; Thornton, J; Valensise, H; Visser, G H A; Wee, L; Truffle-2 Group.

In: ULTRASCHALL MED, Vol. 44, No. 1, 02.2023, p. 56-67.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mylrea-Foley, B, Wolf, H, Stampalija, T, Lees, C, Arabin, B, Berger, A, Bergman, E, Bhide, A, Bilardo, CM, Breeze, AC, Brodszki, J, Calda, P, Cetin, I, Cesari, E, Derks, J, Ebbing, C, Ferrazzi, E, Ganzevoort, W, Frusca, T, Gordijn, SJ, Gyselaers, W, Hecher, K, Klaritsch, P, Krofta, L, Lindgren, P, Lobmaier, SM, Marlow, N, Maruotti, GM, Mecacci, F, Myklestad, K, Napolitano, R, Prefumo, F, Raio, L, Richter, J, Sande, RK, Thornton, J, Valensise, H, Visser, GHA, Wee, L & Truffle-2 Group 2023, 'Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction', ULTRASCHALL MED, vol. 44, no. 1, pp. 56-67. https://doi.org/10.1055/a-1511-8293

APA

Mylrea-Foley, B., Wolf, H., Stampalija, T., Lees, C., Arabin, B., Berger, A., Bergman, E., Bhide, A., Bilardo, C. M., Breeze, A. C., Brodszki, J., Calda, P., Cetin, I., Cesari, E., Derks, J., Ebbing, C., Ferrazzi, E., Ganzevoort, W., Frusca, T., ... Truffle-2 Group (2023). Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction. ULTRASCHALL MED, 44(1), 56-67. https://doi.org/10.1055/a-1511-8293

Vancouver

Mylrea-Foley B, Wolf H, Stampalija T, Lees C, Arabin B, Berger A et al. Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction. ULTRASCHALL MED. 2023 Feb;44(1):56-67. https://doi.org/10.1055/a-1511-8293

Bibtex

@article{90c141ca0ed14f4595a1f6e6f24ec195,
title = "Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction",
abstract = "PURPOSE:  To assess the longitudinal variation of the ratio of umbilical and cerebral artery pulsatility index (UCR) in late preterm fetal growth restriction (FGR).MATERIALS AND METHODS:  A prospective European multicenter observational study included women with a singleton pregnancy, 32+ 0-36+ 6, at risk of FGR (estimated fetal weight [EFW] or abdominal circumference [AC] < 10th percentile, abnormal arterial Doppler or fall in AC from 20-week scan of > 40 percentile points). The primary outcome was a composite of abnormal condition at birth or major neonatal morbidity. UCR was categorized as normal (< 0.9) or abnormal (≥ 0.9). UCR was assessed by gestational age at measurement interval to delivery, and by individual linear regression coefficient in women with two or more measurements.RESULTS:  856 women had 2770 measurements; 696 (81 %) had more than one measurement (median 3 (IQR 2-4). At inclusion, 63 (7 %) a UCR ≥ 0.9. These delivered earlier and had a lower birth weight and higher incidence of adverse outcome (30 % vs. 9 %, relative risk 3.2; 95 %CI 2.1-5.0) than women with a normal UCR at inclusion. Repeated measurements after an abnormal UCR at inclusion were abnormal again in 67 % (95 %CI 55-80), but after a normal UCR the chance of finding an abnormal UCR was 6 % (95 %CI 5-7 %). The risk of composite adverse outcome was similar using the first or subsequent UCR values.CONCLUSION:  An abnormal UCR is likely to be abnormal again at a later measurement, while after a normal UCR the chance of an abnormal UCR is 5-7 % when repeated weekly. Repeated measurements do not predict outcome better than the first measurement, most likely due to the most compromised fetuses being delivered after an abnormal UCR.",
author = "Bronacha Mylrea-Foley and Hans Wolf and Tamara Stampalija and Christoph Lees and B Arabin and A Berger and E Bergman and A Bhide and Bilardo, {C M} and Breeze, {A C} and J Brodszki and P Calda and I Cetin and E Cesari and J Derks and C Ebbing and E Ferrazzi and W Ganzevoort and T Frusca and Gordijn, {S J} and W Gyselaers and K Hecher and P Klaritsch and L Krofta and P Lindgren and Lobmaier, {S M} and N Marlow and Maruotti, {G M} and F Mecacci and K Myklestad and R Napolitano and F Prefumo and L Raio and J Richter and Sande, {R K} and J Thornton and H Valensise and Visser, {G H A} and L Wee and {Truffle-2 Group} and Anke Diemert",
note = "Thieme. All rights reserved.",
year = "2023",
month = feb,
doi = "10.1055/a-1511-8293",
language = "English",
volume = "44",
pages = "56--67",
journal = "ULTRASCHALL MED",
issn = "0172-4614",
publisher = "Georg Thieme Verlag KG",
number = "1",

}

RIS

TY - JOUR

T1 - Longitudinal Doppler Assessments in Late Preterm Fetal Growth Restriction

AU - Mylrea-Foley, Bronacha

AU - Wolf, Hans

AU - Stampalija, Tamara

AU - Lees, Christoph

AU - Arabin, B

AU - Berger, A

AU - Bergman, E

AU - Bhide, A

AU - Bilardo, C M

AU - Breeze, A C

AU - Brodszki, J

AU - Calda, P

AU - Cetin, I

AU - Cesari, E

AU - Derks, J

AU - Ebbing, C

AU - Ferrazzi, E

AU - Ganzevoort, W

AU - Frusca, T

AU - Gordijn, S J

AU - Gyselaers, W

AU - Hecher, K

AU - Klaritsch, P

AU - Krofta, L

AU - Lindgren, P

AU - Lobmaier, S M

AU - Marlow, N

AU - Maruotti, G M

AU - Mecacci, F

AU - Myklestad, K

AU - Napolitano, R

AU - Prefumo, F

AU - Raio, L

AU - Richter, J

AU - Sande, R K

AU - Thornton, J

AU - Valensise, H

AU - Visser, G H A

AU - Wee, L

AU - Truffle-2 Group

AU - Diemert, Anke

N1 - Thieme. All rights reserved.

PY - 2023/2

Y1 - 2023/2

N2 - PURPOSE:  To assess the longitudinal variation of the ratio of umbilical and cerebral artery pulsatility index (UCR) in late preterm fetal growth restriction (FGR).MATERIALS AND METHODS:  A prospective European multicenter observational study included women with a singleton pregnancy, 32+ 0-36+ 6, at risk of FGR (estimated fetal weight [EFW] or abdominal circumference [AC] < 10th percentile, abnormal arterial Doppler or fall in AC from 20-week scan of > 40 percentile points). The primary outcome was a composite of abnormal condition at birth or major neonatal morbidity. UCR was categorized as normal (< 0.9) or abnormal (≥ 0.9). UCR was assessed by gestational age at measurement interval to delivery, and by individual linear regression coefficient in women with two or more measurements.RESULTS:  856 women had 2770 measurements; 696 (81 %) had more than one measurement (median 3 (IQR 2-4). At inclusion, 63 (7 %) a UCR ≥ 0.9. These delivered earlier and had a lower birth weight and higher incidence of adverse outcome (30 % vs. 9 %, relative risk 3.2; 95 %CI 2.1-5.0) than women with a normal UCR at inclusion. Repeated measurements after an abnormal UCR at inclusion were abnormal again in 67 % (95 %CI 55-80), but after a normal UCR the chance of finding an abnormal UCR was 6 % (95 %CI 5-7 %). The risk of composite adverse outcome was similar using the first or subsequent UCR values.CONCLUSION:  An abnormal UCR is likely to be abnormal again at a later measurement, while after a normal UCR the chance of an abnormal UCR is 5-7 % when repeated weekly. Repeated measurements do not predict outcome better than the first measurement, most likely due to the most compromised fetuses being delivered after an abnormal UCR.

AB - PURPOSE:  To assess the longitudinal variation of the ratio of umbilical and cerebral artery pulsatility index (UCR) in late preterm fetal growth restriction (FGR).MATERIALS AND METHODS:  A prospective European multicenter observational study included women with a singleton pregnancy, 32+ 0-36+ 6, at risk of FGR (estimated fetal weight [EFW] or abdominal circumference [AC] < 10th percentile, abnormal arterial Doppler or fall in AC from 20-week scan of > 40 percentile points). The primary outcome was a composite of abnormal condition at birth or major neonatal morbidity. UCR was categorized as normal (< 0.9) or abnormal (≥ 0.9). UCR was assessed by gestational age at measurement interval to delivery, and by individual linear regression coefficient in women with two or more measurements.RESULTS:  856 women had 2770 measurements; 696 (81 %) had more than one measurement (median 3 (IQR 2-4). At inclusion, 63 (7 %) a UCR ≥ 0.9. These delivered earlier and had a lower birth weight and higher incidence of adverse outcome (30 % vs. 9 %, relative risk 3.2; 95 %CI 2.1-5.0) than women with a normal UCR at inclusion. Repeated measurements after an abnormal UCR at inclusion were abnormal again in 67 % (95 %CI 55-80), but after a normal UCR the chance of finding an abnormal UCR was 6 % (95 %CI 5-7 %). The risk of composite adverse outcome was similar using the first or subsequent UCR values.CONCLUSION:  An abnormal UCR is likely to be abnormal again at a later measurement, while after a normal UCR the chance of an abnormal UCR is 5-7 % when repeated weekly. Repeated measurements do not predict outcome better than the first measurement, most likely due to the most compromised fetuses being delivered after an abnormal UCR.

U2 - 10.1055/a-1511-8293

DO - 10.1055/a-1511-8293

M3 - SCORING: Journal article

C2 - 34768305

VL - 44

SP - 56

EP - 67

JO - ULTRASCHALL MED

JF - ULTRASCHALL MED

SN - 0172-4614

IS - 1

ER -