LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival.
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LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival. / Kuhlmann, Jan Dominik; Schwarzenbach, Heidi; Wimberger, Pauline; Poetsch, Micaela; Kimmig, Rainer; Kasimir-Bauer, Sabine.
In: BMC CANCER, Vol. 12, 2012, p. 325.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival.
AU - Kuhlmann, Jan Dominik
AU - Schwarzenbach, Heidi
AU - Wimberger, Pauline
AU - Poetsch, Micaela
AU - Kimmig, Rainer
AU - Kasimir-Bauer, Sabine
PY - 2012
Y1 - 2012
N2 - We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we quantified circulating DNA (cirDNA) in sera of 63 ovarian cancer patients before surgery and after chemotherapy, measured incidence of LOH at four cancer-relevant chromosomal loci, correlated LOH with tumor cell spread to the BM and evaluated prognostic significance of LOH.
AB - We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we quantified circulating DNA (cirDNA) in sera of 63 ovarian cancer patients before surgery and after chemotherapy, measured incidence of LOH at four cancer-relevant chromosomal loci, correlated LOH with tumor cell spread to the BM and evaluated prognostic significance of LOH.
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Young Adult
KW - Prognosis
KW - Neoplasm Staging
KW - Loss of Heterozygosity
KW - DNA, Neoplasm/blood
KW - Neoplastic Cells, Circulating
KW - Neoplasm Grading
KW - Bone Marrow/pathology
KW - Chromosomes, Human, Pair 10
KW - Chromosomes, Human, Pair 6
KW - Ovarian Neoplasms/genetics/mortality/pathology
KW - Tumor Markers, Biological/blood/genetics
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Aged, 80 and over
KW - Young Adult
KW - Prognosis
KW - Neoplasm Staging
KW - Loss of Heterozygosity
KW - DNA, Neoplasm/blood
KW - Neoplastic Cells, Circulating
KW - Neoplasm Grading
KW - Bone Marrow/pathology
KW - Chromosomes, Human, Pair 10
KW - Chromosomes, Human, Pair 6
KW - Ovarian Neoplasms/genetics/mortality/pathology
KW - Tumor Markers, Biological/blood/genetics
U2 - 10.1186/1471-2407-12-325
DO - 10.1186/1471-2407-12-325
M3 - SCORING: Journal article
VL - 12
SP - 325
JO - BMC CANCER
JF - BMC CANCER
SN - 1471-2407
ER -