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LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival.

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LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival. / Kuhlmann, Jan Dominik; Schwarzenbach, Heidi; Wimberger, Pauline; Poetsch, Micaela; Kimmig, Rainer; Kasimir-Bauer, Sabine.

in: BMC CANCER, Jahrgang 12, 2012, S. 325.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kuhlmann, JD, Schwarzenbach, H, Wimberger, P, Poetsch, M, Kimmig, R & Kasimir-Bauer, S 2012, 'LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival.', BMC CANCER, Jg. 12, S. 325. https://doi.org/10.1186/1471-2407-12-325

APA

Kuhlmann, J. D., Schwarzenbach, H., Wimberger, P., Poetsch, M., Kimmig, R., & Kasimir-Bauer, S. (2012). LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival. BMC CANCER, 12, 325. https://doi.org/10.1186/1471-2407-12-325

Vancouver

Kuhlmann JD, Schwarzenbach H, Wimberger P, Poetsch M, Kimmig R, Kasimir-Bauer S. LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival. BMC CANCER. 2012;12:325. https://doi.org/10.1186/1471-2407-12-325

Bibtex

@article{a6c8bb1e9fb24890a6955cfb0cd2383b,
title = "LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival.",
abstract = "We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we quantified circulating DNA (cirDNA) in sera of 63 ovarian cancer patients before surgery and after chemotherapy, measured incidence of LOH at four cancer-relevant chromosomal loci, correlated LOH with tumor cell spread to the BM and evaluated prognostic significance of LOH.",
keywords = "Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Young Adult, Prognosis, Neoplasm Staging, *Loss of Heterozygosity, DNA, Neoplasm/*blood, Neoplastic Cells, Circulating, Neoplasm Grading, Bone Marrow/pathology, *Chromosomes, Human, Pair 10, *Chromosomes, Human, Pair 6, Ovarian Neoplasms/*genetics/mortality/pathology, Tumor Markers, Biological/blood/genetics, Adult, Humans, Aged, Female, Middle Aged, Aged, 80 and over, Young Adult, Prognosis, Neoplasm Staging, *Loss of Heterozygosity, DNA, Neoplasm/*blood, Neoplastic Cells, Circulating, Neoplasm Grading, Bone Marrow/pathology, *Chromosomes, Human, Pair 10, *Chromosomes, Human, Pair 6, Ovarian Neoplasms/*genetics/mortality/pathology, Tumor Markers, Biological/blood/genetics",
author = "Kuhlmann, {Jan Dominik} and Heidi Schwarzenbach and Pauline Wimberger and Micaela Poetsch and Rainer Kimmig and Sabine Kasimir-Bauer",
year = "2012",
doi = "10.1186/1471-2407-12-325",
language = "English",
volume = "12",
pages = "325",
journal = "BMC CANCER",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival.

AU - Kuhlmann, Jan Dominik

AU - Schwarzenbach, Heidi

AU - Wimberger, Pauline

AU - Poetsch, Micaela

AU - Kimmig, Rainer

AU - Kasimir-Bauer, Sabine

PY - 2012

Y1 - 2012

N2 - We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we quantified circulating DNA (cirDNA) in sera of 63 ovarian cancer patients before surgery and after chemotherapy, measured incidence of LOH at four cancer-relevant chromosomal loci, correlated LOH with tumor cell spread to the BM and evaluated prognostic significance of LOH.

AB - We recently showed that LOH proximal to M6P/IGF2R locus (D6S1581) in primary ovarian tumors is predictive for the presence of disseminated tumor cells (DTC) in the bone marrow (BM). For therapy-monitoring, it would be highly desirable to establish a blood-based biomarker. Therefore, we quantified circulating DNA (cirDNA) in sera of 63 ovarian cancer patients before surgery and after chemotherapy, measured incidence of LOH at four cancer-relevant chromosomal loci, correlated LOH with tumor cell spread to the BM and evaluated prognostic significance of LOH.

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Young Adult

KW - Prognosis

KW - Neoplasm Staging

KW - Loss of Heterozygosity

KW - DNA, Neoplasm/blood

KW - Neoplastic Cells, Circulating

KW - Neoplasm Grading

KW - Bone Marrow/pathology

KW - Chromosomes, Human, Pair 10

KW - Chromosomes, Human, Pair 6

KW - Ovarian Neoplasms/genetics/mortality/pathology

KW - Tumor Markers, Biological/blood/genetics

KW - Adult

KW - Humans

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Young Adult

KW - Prognosis

KW - Neoplasm Staging

KW - Loss of Heterozygosity

KW - DNA, Neoplasm/blood

KW - Neoplastic Cells, Circulating

KW - Neoplasm Grading

KW - Bone Marrow/pathology

KW - Chromosomes, Human, Pair 10

KW - Chromosomes, Human, Pair 6

KW - Ovarian Neoplasms/genetics/mortality/pathology

KW - Tumor Markers, Biological/blood/genetics

U2 - 10.1186/1471-2407-12-325

DO - 10.1186/1471-2407-12-325

M3 - SCORING: Journal article

VL - 12

SP - 325

JO - BMC CANCER

JF - BMC CANCER

SN - 1471-2407

ER -