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Locus coeruleus MRI contrast is associated with cortical thickness in older adults

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Locus coeruleus MRI contrast is associated with cortical thickness in older adults. / Bachman, Shelby L; Dahl, Martin J; Werkle-Bergner, Markus; Düzel, Sandra; Forlim, Caroline Garcia; Lindenberger, Ulman; Kühn, Simone; Mather, Mara.

In: NEUROBIOL AGING, Vol. 100, 04.2021, p. 72-82.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bachman, SL, Dahl, MJ, Werkle-Bergner, M, Düzel, S, Forlim, CG, Lindenberger, U, Kühn, S & Mather, M 2021, 'Locus coeruleus MRI contrast is associated with cortical thickness in older adults', NEUROBIOL AGING, vol. 100, pp. 72-82. https://doi.org/10.1016/j.neurobiolaging.2020.12.019

APA

Bachman, S. L., Dahl, M. J., Werkle-Bergner, M., Düzel, S., Forlim, C. G., Lindenberger, U., Kühn, S., & Mather, M. (2021). Locus coeruleus MRI contrast is associated with cortical thickness in older adults. NEUROBIOL AGING, 100, 72-82. https://doi.org/10.1016/j.neurobiolaging.2020.12.019

Vancouver

Bachman SL, Dahl MJ, Werkle-Bergner M, Düzel S, Forlim CG, Lindenberger U et al. Locus coeruleus MRI contrast is associated with cortical thickness in older adults. NEUROBIOL AGING. 2021 Apr;100:72-82. https://doi.org/10.1016/j.neurobiolaging.2020.12.019

Bibtex

@article{8eee96d3d764408d89c366be9a886d60,
title = "Locus coeruleus MRI contrast is associated with cortical thickness in older adults",
abstract = "There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults. Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The FreeSurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Aging/physiology, Attention, Cerebral Cortex/diagnostic imaging, Cognition, Female, Humans, Locus Coeruleus/diagnostic imaging, Magnetic Resonance Imaging, Male, Memory, Middle Aged, Pons/diagnostic imaging",
author = "Bachman, {Shelby L} and Dahl, {Martin J} and Markus Werkle-Bergner and Sandra D{\"u}zel and Forlim, {Caroline Garcia} and Ulman Lindenberger and Simone K{\"u}hn and Mara Mather",
note = "Copyright {\textcopyright} 2021 Elsevier Inc. All rights reserved.",
year = "2021",
month = apr,
doi = "10.1016/j.neurobiolaging.2020.12.019",
language = "English",
volume = "100",
pages = "72--82",
journal = "NEUROBIOL AGING",
issn = "0197-4580",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Locus coeruleus MRI contrast is associated with cortical thickness in older adults

AU - Bachman, Shelby L

AU - Dahl, Martin J

AU - Werkle-Bergner, Markus

AU - Düzel, Sandra

AU - Forlim, Caroline Garcia

AU - Lindenberger, Ulman

AU - Kühn, Simone

AU - Mather, Mara

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults. Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The FreeSurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.

AB - There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults. Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The FreeSurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Aging/physiology

KW - Attention

KW - Cerebral Cortex/diagnostic imaging

KW - Cognition

KW - Female

KW - Humans

KW - Locus Coeruleus/diagnostic imaging

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory

KW - Middle Aged

KW - Pons/diagnostic imaging

U2 - 10.1016/j.neurobiolaging.2020.12.019

DO - 10.1016/j.neurobiolaging.2020.12.019

M3 - SCORING: Journal article

C2 - 33508564

VL - 100

SP - 72

EP - 82

JO - NEUROBIOL AGING

JF - NEUROBIOL AGING

SN - 0197-4580

ER -