Locus coeruleus MRI contrast is associated with cortical thickness in older adults
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Locus coeruleus MRI contrast is associated with cortical thickness in older adults. / Bachman, Shelby L; Dahl, Martin J; Werkle-Bergner, Markus; Düzel, Sandra; Forlim, Caroline Garcia; Lindenberger, Ulman; Kühn, Simone; Mather, Mara.
in: NEUROBIOL AGING, Jahrgang 100, 04.2021, S. 72-82.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Locus coeruleus MRI contrast is associated with cortical thickness in older adults
AU - Bachman, Shelby L
AU - Dahl, Martin J
AU - Werkle-Bergner, Markus
AU - Düzel, Sandra
AU - Forlim, Caroline Garcia
AU - Lindenberger, Ulman
AU - Kühn, Simone
AU - Mather, Mara
N1 - Copyright © 2021 Elsevier Inc. All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults. Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The FreeSurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.
AB - There is growing evidence that neuronal integrity of the noradrenergic locus coeruleus (LC) is important for later-life cognition. Less understood is how LC integrity relates to brain correlates of cognition, such as brain structure. Here, we examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults. Using a magnetic resonance imaging sequence which yields high signal intensity in the LC, we assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue. The FreeSurfer software suite was used to quantify cortical thickness. LC contrast was positively related to cortical thickness in older adults, and this association was prominent in parietal, frontal, and occipital regions. Brain regions where LC contrast was related to cortical thickness include portions of the frontoparietal network which have been implicated in noradrenergically modulated cognitive functions. These findings provide novel evidence for a link between LC structure and cortical brain structure in later adulthood.
KW - Adult
KW - Age Factors
KW - Aged
KW - Aged, 80 and over
KW - Aging/physiology
KW - Attention
KW - Cerebral Cortex/diagnostic imaging
KW - Cognition
KW - Female
KW - Humans
KW - Locus Coeruleus/diagnostic imaging
KW - Magnetic Resonance Imaging
KW - Male
KW - Memory
KW - Middle Aged
KW - Pons/diagnostic imaging
U2 - 10.1016/j.neurobiolaging.2020.12.019
DO - 10.1016/j.neurobiolaging.2020.12.019
M3 - SCORING: Journal article
C2 - 33508564
VL - 100
SP - 72
EP - 82
JO - NEUROBIOL AGING
JF - NEUROBIOL AGING
SN - 0197-4580
ER -