Research ExplorerPublicationsLiver transplantation as a primary indication for intrahepat...

Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma

Standard

Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma : a single-center experience. / Sotiropoulos, G C; Kaiser, G M; Lang, H; Molmenti, E P; Beckebaum, S; Fouzas, I; Sgourakis, G; Radtke, A; Bockhorn, M; Nadalin, S; Treckmann, J; Niebel, W; Baba, H A; Broelsch, C E; Paul, A.

In: TRANSPL P, Vol. 40, No. 9, 01.11.2008, p. 3194-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sotiropoulos, GC, Kaiser, GM, Lang, H, Molmenti, EP, Beckebaum, S, Fouzas, I, Sgourakis, G, Radtke, A, Bockhorn, M, Nadalin, S, Treckmann, J, Niebel, W, Baba, HA, Broelsch, CE & Paul, A 2008, 'Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma: a single-center experience', TRANSPL P, vol. 40, no. 9, pp. 3194-5. https://doi.org/10.1016/j.transproceed.2008.08.053

APA

Sotiropoulos, G. C., Kaiser, G. M., Lang, H., Molmenti, E. P., Beckebaum, S., Fouzas, I., Sgourakis, G., Radtke, A., Bockhorn, M., Nadalin, S., Treckmann, J., Niebel, W., Baba, H. A., Broelsch, C. E., & Paul, A. (2008). Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma: a single-center experience. TRANSPL P, 40(9), 3194-5. https://doi.org/10.1016/j.transproceed.2008.08.053

Vancouver

Sotiropoulos GC, Kaiser GM, Lang H, Molmenti EP, Beckebaum S, Fouzas I et al. Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma: a single-center experience. TRANSPL P. 2008 Nov 1;40(9):3194-5. https://doi.org/10.1016/j.transproceed.2008.08.053

Bibtex

@article{8237591f1f9646cbb5b2be9d6ea87e3e,
title = "Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma: a single-center experience",
abstract = "BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is not a widely accepted indication for orthotopic liver transplantation (OLT). The present study describes our institutional experience with patients who underwent transplantation for ICC as well as those with ICC who underwent transplantation with the incorrect diagnosis of hepatocellular carcinoma (HCC).PATIENTS AND METHODS: Data corresponding to ICC patients were reviewed for the purposes of this study. Patients with hilar cholangiocarcinoma and incidentally found ICC after OLT for benign diseases were excluded from further consideration.RESULTS: Among the 10 patients, 6 underwent transplantation before 1996 and 4 after 2001. Those who underwent transplantation in the early period had a preoperative diagnosis of inoperable ICC (n = 4) and ICC in the setting of primary sclerosing cholangitis (n = 2). In the latter period the subjects had a diagnosis of HCC in cirrhosis (n = 3) or recurrent ICC after an extended right hepatectomy (n = 1). Median survival was 25.3 months for the whole series and 32.2 months (range, 18-130 months) when hospital mortality was excluded (n = 3). Four patients are currently alive after 30, 35, 42, and 130 months post-OLT, respectively. Two patients died of tumor recurrence at 18 and 21 months post-OLT, respectively. One-, 3-, and 5-year survival rates were 70%, 50%, and 33%, respectively.CONCLUSIONS: The role of OLT in the setting of ICC may be re-evaluated in the future under strict selection criteria and with prospective multicenter randomized studies. Potential candidates to be included are those with liver cirrhosis and no hilar involvement who meet the Milan criteria for HCC.",
keywords = "Bile Duct Neoplasms, Bile Ducts, Intrahepatic, Cholangiocarcinoma, Follow-Up Studies, Hepatectomy, Hospital Mortality, Humans, Liver Transplantation, Retrospective Studies, Survival Rate, Survivors, Time Factors",
author = "Sotiropoulos, {G C} and Kaiser, {G M} and H Lang and Molmenti, {E P} and S Beckebaum and I Fouzas and G Sgourakis and A Radtke and M Bockhorn and S Nadalin and J Treckmann and W Niebel and Baba, {H A} and Broelsch, {C E} and A Paul",
year = "2008",
month = nov,
day = "1",
doi = "10.1016/j.transproceed.2008.08.053",
language = "English",
volume = "40",
pages = "3194--5",
journal = "TRANSPL P",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "9",

}

RIS

TY - JOUR

T1 - Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma

T2 - a single-center experience

AU - Sotiropoulos, G C

AU - Kaiser, G M

AU - Lang, H

AU - Molmenti, E P

AU - Beckebaum, S

AU - Fouzas, I

AU - Sgourakis, G

AU - Radtke, A

AU - Bockhorn, M

AU - Nadalin, S

AU - Treckmann, J

AU - Niebel, W

AU - Baba, H A

AU - Broelsch, C E

AU - Paul, A

PY - 2008/11/1

Y1 - 2008/11/1

N2 - BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is not a widely accepted indication for orthotopic liver transplantation (OLT). The present study describes our institutional experience with patients who underwent transplantation for ICC as well as those with ICC who underwent transplantation with the incorrect diagnosis of hepatocellular carcinoma (HCC).PATIENTS AND METHODS: Data corresponding to ICC patients were reviewed for the purposes of this study. Patients with hilar cholangiocarcinoma and incidentally found ICC after OLT for benign diseases were excluded from further consideration.RESULTS: Among the 10 patients, 6 underwent transplantation before 1996 and 4 after 2001. Those who underwent transplantation in the early period had a preoperative diagnosis of inoperable ICC (n = 4) and ICC in the setting of primary sclerosing cholangitis (n = 2). In the latter period the subjects had a diagnosis of HCC in cirrhosis (n = 3) or recurrent ICC after an extended right hepatectomy (n = 1). Median survival was 25.3 months for the whole series and 32.2 months (range, 18-130 months) when hospital mortality was excluded (n = 3). Four patients are currently alive after 30, 35, 42, and 130 months post-OLT, respectively. Two patients died of tumor recurrence at 18 and 21 months post-OLT, respectively. One-, 3-, and 5-year survival rates were 70%, 50%, and 33%, respectively.CONCLUSIONS: The role of OLT in the setting of ICC may be re-evaluated in the future under strict selection criteria and with prospective multicenter randomized studies. Potential candidates to be included are those with liver cirrhosis and no hilar involvement who meet the Milan criteria for HCC.

AB - BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is not a widely accepted indication for orthotopic liver transplantation (OLT). The present study describes our institutional experience with patients who underwent transplantation for ICC as well as those with ICC who underwent transplantation with the incorrect diagnosis of hepatocellular carcinoma (HCC).PATIENTS AND METHODS: Data corresponding to ICC patients were reviewed for the purposes of this study. Patients with hilar cholangiocarcinoma and incidentally found ICC after OLT for benign diseases were excluded from further consideration.RESULTS: Among the 10 patients, 6 underwent transplantation before 1996 and 4 after 2001. Those who underwent transplantation in the early period had a preoperative diagnosis of inoperable ICC (n = 4) and ICC in the setting of primary sclerosing cholangitis (n = 2). In the latter period the subjects had a diagnosis of HCC in cirrhosis (n = 3) or recurrent ICC after an extended right hepatectomy (n = 1). Median survival was 25.3 months for the whole series and 32.2 months (range, 18-130 months) when hospital mortality was excluded (n = 3). Four patients are currently alive after 30, 35, 42, and 130 months post-OLT, respectively. Two patients died of tumor recurrence at 18 and 21 months post-OLT, respectively. One-, 3-, and 5-year survival rates were 70%, 50%, and 33%, respectively.CONCLUSIONS: The role of OLT in the setting of ICC may be re-evaluated in the future under strict selection criteria and with prospective multicenter randomized studies. Potential candidates to be included are those with liver cirrhosis and no hilar involvement who meet the Milan criteria for HCC.

KW - Bile Duct Neoplasms

KW - Bile Ducts, Intrahepatic

KW - Cholangiocarcinoma

KW - Follow-Up Studies

KW - Hepatectomy

KW - Hospital Mortality

KW - Humans

KW - Liver Transplantation

KW - Retrospective Studies

KW - Survival Rate

KW - Survivors

KW - Time Factors

U2 - 10.1016/j.transproceed.2008.08.053

DO - 10.1016/j.transproceed.2008.08.053

M3 - SCORING: Journal article

C2 - 19010231

VL - 40

SP - 3194

EP - 3195

JO - TRANSPL P

JF - TRANSPL P

SN - 0041-1345

IS - 9

ER -