Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma
Standard
Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma : a single-center experience. / Sotiropoulos, G C; Kaiser, G M; Lang, H; Molmenti, E P; Beckebaum, S; Fouzas, I; Sgourakis, G; Radtke, A; Bockhorn, M; Nadalin, S; Treckmann, J; Niebel, W; Baba, H A; Broelsch, C E; Paul, A.
in: TRANSPL P, Jahrgang 40, Nr. 9, 01.11.2008, S. 3194-5.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Liver transplantation as a primary indication for intrahepatic cholangiocarcinoma
T2 - a single-center experience
AU - Sotiropoulos, G C
AU - Kaiser, G M
AU - Lang, H
AU - Molmenti, E P
AU - Beckebaum, S
AU - Fouzas, I
AU - Sgourakis, G
AU - Radtke, A
AU - Bockhorn, M
AU - Nadalin, S
AU - Treckmann, J
AU - Niebel, W
AU - Baba, H A
AU - Broelsch, C E
AU - Paul, A
PY - 2008/11/1
Y1 - 2008/11/1
N2 - BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is not a widely accepted indication for orthotopic liver transplantation (OLT). The present study describes our institutional experience with patients who underwent transplantation for ICC as well as those with ICC who underwent transplantation with the incorrect diagnosis of hepatocellular carcinoma (HCC).PATIENTS AND METHODS: Data corresponding to ICC patients were reviewed for the purposes of this study. Patients with hilar cholangiocarcinoma and incidentally found ICC after OLT for benign diseases were excluded from further consideration.RESULTS: Among the 10 patients, 6 underwent transplantation before 1996 and 4 after 2001. Those who underwent transplantation in the early period had a preoperative diagnosis of inoperable ICC (n = 4) and ICC in the setting of primary sclerosing cholangitis (n = 2). In the latter period the subjects had a diagnosis of HCC in cirrhosis (n = 3) or recurrent ICC after an extended right hepatectomy (n = 1). Median survival was 25.3 months for the whole series and 32.2 months (range, 18-130 months) when hospital mortality was excluded (n = 3). Four patients are currently alive after 30, 35, 42, and 130 months post-OLT, respectively. Two patients died of tumor recurrence at 18 and 21 months post-OLT, respectively. One-, 3-, and 5-year survival rates were 70%, 50%, and 33%, respectively.CONCLUSIONS: The role of OLT in the setting of ICC may be re-evaluated in the future under strict selection criteria and with prospective multicenter randomized studies. Potential candidates to be included are those with liver cirrhosis and no hilar involvement who meet the Milan criteria for HCC.
AB - BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is not a widely accepted indication for orthotopic liver transplantation (OLT). The present study describes our institutional experience with patients who underwent transplantation for ICC as well as those with ICC who underwent transplantation with the incorrect diagnosis of hepatocellular carcinoma (HCC).PATIENTS AND METHODS: Data corresponding to ICC patients were reviewed for the purposes of this study. Patients with hilar cholangiocarcinoma and incidentally found ICC after OLT for benign diseases were excluded from further consideration.RESULTS: Among the 10 patients, 6 underwent transplantation before 1996 and 4 after 2001. Those who underwent transplantation in the early period had a preoperative diagnosis of inoperable ICC (n = 4) and ICC in the setting of primary sclerosing cholangitis (n = 2). In the latter period the subjects had a diagnosis of HCC in cirrhosis (n = 3) or recurrent ICC after an extended right hepatectomy (n = 1). Median survival was 25.3 months for the whole series and 32.2 months (range, 18-130 months) when hospital mortality was excluded (n = 3). Four patients are currently alive after 30, 35, 42, and 130 months post-OLT, respectively. Two patients died of tumor recurrence at 18 and 21 months post-OLT, respectively. One-, 3-, and 5-year survival rates were 70%, 50%, and 33%, respectively.CONCLUSIONS: The role of OLT in the setting of ICC may be re-evaluated in the future under strict selection criteria and with prospective multicenter randomized studies. Potential candidates to be included are those with liver cirrhosis and no hilar involvement who meet the Milan criteria for HCC.
KW - Bile Duct Neoplasms
KW - Bile Ducts, Intrahepatic
KW - Cholangiocarcinoma
KW - Follow-Up Studies
KW - Hepatectomy
KW - Hospital Mortality
KW - Humans
KW - Liver Transplantation
KW - Retrospective Studies
KW - Survival Rate
KW - Survivors
KW - Time Factors
U2 - 10.1016/j.transproceed.2008.08.053
DO - 10.1016/j.transproceed.2008.08.053
M3 - SCORING: Journal article
C2 - 19010231
VL - 40
SP - 3194
EP - 3195
JO - TRANSPL P
JF - TRANSPL P
SN - 0041-1345
IS - 9
ER -