Research ExplorerPublicationsLipoprotein-associated phospholipase A2 concentrations in pl...

Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids

Standard

Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids. / Schmidt, Erik Berg; Koenig, Wolfgang; Khuseyinova, Natalie; Christensen, Jeppe Hagstrup.

In: ATHEROSCLEROSIS, Vol. 196, No. 1, 01.2008, p. 420-424.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Schmidt, EB, Koenig, W, Khuseyinova, N & Christensen, JH 2008, 'Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids', ATHEROSCLEROSIS, vol. 196, no. 1, pp. 420-424. https://doi.org/10.1016/j.atherosclerosis.2006.11.027

APA

Schmidt, E. B., Koenig, W., Khuseyinova, N., & Christensen, J. H. (2008). Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids. ATHEROSCLEROSIS, 196(1), 420-424. https://doi.org/10.1016/j.atherosclerosis.2006.11.027

Vancouver

Schmidt EB, Koenig W, Khuseyinova N, Christensen JH. Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids. ATHEROSCLEROSIS. 2008 Jan;196(1):420-424. https://doi.org/10.1016/j.atherosclerosis.2006.11.027

Bibtex

@article{5c897c844c4e4309ba6a981fe4fbd6b8,
title = "Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids",
abstract = "Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.",
keywords = "1-Alkyl-2-acetylglycerophosphocholine Esterase/blood, Adipose Tissue/chemistry, Aged, Coronary Artery Disease/blood, Denmark, Fatty Acids, Omega-3/analysis, Female, Humans, Linear Models, Male, Middle Aged, Risk Factors, Seafood",
author = "Schmidt, {Erik Berg} and Wolfgang Koenig and Natalie Khuseyinova and Christensen, {Jeppe Hagstrup}",
year = "2008",
month = jan,
doi = "10.1016/j.atherosclerosis.2006.11.027",
language = "English",
volume = "196",
pages = "420--424",
journal = "ATHEROSCLEROSIS",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids

AU - Schmidt, Erik Berg

AU - Koenig, Wolfgang

AU - Khuseyinova, Natalie

AU - Christensen, Jeppe Hagstrup

PY - 2008/1

Y1 - 2008/1

N2 - Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.

AB - Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.

KW - 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood

KW - Adipose Tissue/chemistry

KW - Aged

KW - Coronary Artery Disease/blood

KW - Denmark

KW - Fatty Acids, Omega-3/analysis

KW - Female

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Seafood

U2 - 10.1016/j.atherosclerosis.2006.11.027

DO - 10.1016/j.atherosclerosis.2006.11.027

M3 - SCORING: Journal article

C2 - 17157859

VL - 196

SP - 420

EP - 424

JO - ATHEROSCLEROSIS

JF - ATHEROSCLEROSIS

SN - 0021-9150

IS - 1

ER -