Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids
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Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids. / Schmidt, Erik Berg; Koenig, Wolfgang; Khuseyinova, Natalie; Christensen, Jeppe Hagstrup.
in: ATHEROSCLEROSIS, Jahrgang 196, Nr. 1, 01.2008, S. 420-424.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung
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T1 - Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids
AU - Schmidt, Erik Berg
AU - Koenig, Wolfgang
AU - Khuseyinova, Natalie
AU - Christensen, Jeppe Hagstrup
PY - 2008/1
Y1 - 2008/1
N2 - Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.
AB - Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.
KW - 1-Alkyl-2-acetylglycerophosphocholine Esterase/blood
KW - Adipose Tissue/chemistry
KW - Aged
KW - Coronary Artery Disease/blood
KW - Denmark
KW - Fatty Acids, Omega-3/analysis
KW - Female
KW - Humans
KW - Linear Models
KW - Male
KW - Middle Aged
KW - Risk Factors
KW - Seafood
U2 - 10.1016/j.atherosclerosis.2006.11.027
DO - 10.1016/j.atherosclerosis.2006.11.027
M3 - SCORING: Journal article
C2 - 17157859
VL - 196
SP - 420
EP - 424
JO - ATHEROSCLEROSIS
JF - ATHEROSCLEROSIS
SN - 0021-9150
IS - 1
ER -