Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)
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Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO). / Mikolajczyk, Rafael; Diexer, Sophie; Klee, Bianca; Pfrommer, Laura; Purschke, Oliver; Fricke, Julia; Ahnert, Peter; Gabrysch, Sabine; Gottschick, Cornelia; Bohn, Barbara; Brenner, Hermann; Buck, Christoph; Castell, Stefanie; Gastell, Sylvia; Greiser, Karin Halina; Harth, Volker; Heise, Jana-Kristin; Holleczek, Bernd; Kaaks, Rudolf; Keil, Thomas; Krist, Lilian; Leitzmann, Michael; Lieb, Wolfgang; Meinke-Franze, Claudia; Michels, Karin B; Velásquez, Ilais Moreno; Obi, Nadia; Panreck, Leo; Peters, Annette; Pischon, Tobias; Schikowski, Tamara; Schmidt, Börge; Standl, Marie; Stang, Andreas; Völzke, Henry; Weber, Andrea; Zeeb, Hajo; Karch, André.
In: J INFECTION, Vol. 89, No. 2, 08.2024, p. 106206.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Likelihood of Post-COVID Condition in people with hybrid immunity; data from the German National Cohort (NAKO)
AU - Mikolajczyk, Rafael
AU - Diexer, Sophie
AU - Klee, Bianca
AU - Pfrommer, Laura
AU - Purschke, Oliver
AU - Fricke, Julia
AU - Ahnert, Peter
AU - Gabrysch, Sabine
AU - Gottschick, Cornelia
AU - Bohn, Barbara
AU - Brenner, Hermann
AU - Buck, Christoph
AU - Castell, Stefanie
AU - Gastell, Sylvia
AU - Greiser, Karin Halina
AU - Harth, Volker
AU - Heise, Jana-Kristin
AU - Holleczek, Bernd
AU - Kaaks, Rudolf
AU - Keil, Thomas
AU - Krist, Lilian
AU - Leitzmann, Michael
AU - Lieb, Wolfgang
AU - Meinke-Franze, Claudia
AU - Michels, Karin B
AU - Velásquez, Ilais Moreno
AU - Obi, Nadia
AU - Panreck, Leo
AU - Peters, Annette
AU - Pischon, Tobias
AU - Schikowski, Tamara
AU - Schmidt, Börge
AU - Standl, Marie
AU - Stang, Andreas
AU - Völzke, Henry
AU - Weber, Andrea
AU - Zeeb, Hajo
AU - Karch, André
N1 - Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2024/8
Y1 - 2024/8
N2 - OBJECTIVES: The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear.METHODS: Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms).RESULTS: Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61).CONCLUSIONS: Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.
AB - OBJECTIVES: The risk of Post-COVID-19 condition (PCC) under hybrid immunity remains unclear.METHODS: Using data from the German National Cohort (NAKO Gesundheitsstudie), we investigated risk factors for self-reported post-infection symptoms (any PCC is defined as having at least one symptom, and high symptom burden PCC as having nine or more symptoms).RESULTS: Sixty percent of 109,707 participants reported at least one previous SARS-CoV-2 infection; 35% reported having had any symptoms 4-12 months after infection; among them 23% reported nine or more symptoms. Individuals, who did not develop PCC after their first infection, had a strongly reduced risk for PCC after their second infection (50%) and a temporary risk reduction, which waned over 9 months after the preceding infection. The risk of developing PCC strongly depended on the virus variant. Within variants, there was no effect of the number of preceding vaccinations, apart from a strong protection by the fourth vaccination compared to three vaccinations for the Omicron variant (odds ratio = 0.52; 95% confidence interval 0.45-0.61).CONCLUSIONS: Previous infections without PCC and a fourth vaccination were associated with a lower risk of PCC after a new infection, indicating diminished risk under hybrid immunity. The two components of risk reduction after a preceding infection suggest different immunological mechanisms.
U2 - 10.1016/j.jinf.2024.106206
DO - 10.1016/j.jinf.2024.106206
M3 - SCORING: Journal article
C2 - 38897239
VL - 89
SP - 106206
JO - J INFECTION
JF - J INFECTION
SN - 0163-4453
IS - 2
ER -